北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
Tumor MET Expression and Gene Amplification in Chinese Patients with Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer
作者: Peng, Zhi1; Li, Zhongwu2; Gao, Jing1; Lu, Ming1; Gong, Jifang1; Tang, En-Tzu3; Oliner, Kelly S.4; Hei, Yong-Jiang5; Zhou, Hui6; Shen, Lin1
刊名: MOLECULAR CANCER THERAPEUTICS
发表日期: 2015-11-01
DOI: 10.1158/1535-7163.MCT-15-0108
卷: 14, 期:11, 页:2634-2641
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GROWTH-FACTOR RECEPTOR ; RANDOMIZED PHASE-III ; CELL LUNG-CANCER ; C-ERB B-2 ; 1ST-LINE THERAPY ; ESOPHAGOGASTRIC JUNCTION ; PROGNOSTIC-SIGNIFICANCE ; TARGETED THERAPIES ; POOR-PROGNOSIS ; DOUBLE-BLIND
英文摘要:

MET and its sole ligand, hepatocyte growth factor (HGF), are promising targets in gastric and gastroesophageal junction cancer. We evaluated whether MET protein expression or MET gene amplification is prognostic for overall survival (OS) in Chinese patients with advanced gastric or gastroesophageal junction cancer. Archival formalin-fixed, paraffin-embedded tumor samples from patients with unresectable locally advanced or metastatic gastric or gastroesophageal junction cancer enrolled in clinical trials at Peking University Cancer Hospital from 2008 to 2010 were assessed for MET and phospho-MET (p-MET) expression by immunohistochemistry and MET amplification by FISH. MET-positive expression was defined as membrane protein staining in >= 25% of tumor cells. MET amplification was defined as MET: centromere 7 ratio >2.0. We tested the association of MET status with clinical characteristics and OS, and also evaluated the association between expression and amplification. One hundred sixty-eight patients were eligible. Of the evaluable samples, 53 of 137 (39%) were MET positive, eight of 134 (6%) were p-MET positive, and eight of 113 (7%) were MET amplified. Neither MET expression nor MET amplification were associated with clinical characteristics, except Lauren classification (P = 0.04); MET amplification was associated with diffuse type. No significant OS difference was observed between MET-positive and MET-negative populations, regardless of first-line chemotherapy received. In 95 evaluable patients, MET expression was significantly associated with MET amplification (P < 0.001); all MET-amplified tumor samples showed some MET expression. In 96 evaluable patients, p-MET positivity was significantly associated with MET amplification (P < 0.001). Further evaluation in larger and independent sample sets is warranted to confirm our findings. (C) 2015 AACR.

语种: 英语
WOS记录号: WOS:000364592000023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53058
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Amgen Inc, Biostat Sci, Shanghai, Peoples R China
2.Amgen Inc, Mol Sci, Thousand Oaks, CA 91320 USA
3.Amgen Inc, Global Dev, Shanghai, Peoples R China
4.Amgen Inc, Med Dept, Shanghai, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Beijing 100871, Peoples R China
6.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Peng, Zhi,Li, Zhongwu,Gao, Jing,et al. Tumor MET Expression and Gene Amplification in Chinese Patients with Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer[J]. MOLECULAR CANCER THERAPEUTICS,2015,14(11):2634-2641.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Peng, Zhi]'s Articles
[Li, Zhongwu]'s Articles
[Gao, Jing]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Peng, Zhi]‘s Articles
[Li, Zhongwu]‘s Articles
[Gao, Jing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace