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学科主题临床医学
Tumor MET Expression and Gene Amplification in Chinese Patients with Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer
Peng, Zhi1; Li, Zhongwu2; Gao, Jing1; Lu, Ming1; Gong, Jifang1; Tang, En-Tzu3; Oliner, Kelly S.4; Hei, Yong-Jiang5; Zhou, Hui6; Shen, Lin1
刊名MOLECULAR CANCER THERAPEUTICS
2015-11-01
DOI10.1158/1535-7163.MCT-15-0108
14期:11页:2634-2641
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]GROWTH-FACTOR RECEPTOR ; RANDOMIZED PHASE-III ; CELL LUNG-CANCER ; C-ERB B-2 ; 1ST-LINE THERAPY ; ESOPHAGOGASTRIC JUNCTION ; PROGNOSTIC-SIGNIFICANCE ; TARGETED THERAPIES ; POOR-PROGNOSIS ; DOUBLE-BLIND
英文摘要

MET and its sole ligand, hepatocyte growth factor (HGF), are promising targets in gastric and gastroesophageal junction cancer. We evaluated whether MET protein expression or MET gene amplification is prognostic for overall survival (OS) in Chinese patients with advanced gastric or gastroesophageal junction cancer. Archival formalin-fixed, paraffin-embedded tumor samples from patients with unresectable locally advanced or metastatic gastric or gastroesophageal junction cancer enrolled in clinical trials at Peking University Cancer Hospital from 2008 to 2010 were assessed for MET and phospho-MET (p-MET) expression by immunohistochemistry and MET amplification by FISH. MET-positive expression was defined as membrane protein staining in >= 25% of tumor cells. MET amplification was defined as MET: centromere 7 ratio >2.0. We tested the association of MET status with clinical characteristics and OS, and also evaluated the association between expression and amplification. One hundred sixty-eight patients were eligible. Of the evaluable samples, 53 of 137 (39%) were MET positive, eight of 134 (6%) were p-MET positive, and eight of 113 (7%) were MET amplified. Neither MET expression nor MET amplification were associated with clinical characteristics, except Lauren classification (P = 0.04); MET amplification was associated with diffuse type. No significant OS difference was observed between MET-positive and MET-negative populations, regardless of first-line chemotherapy received. In 95 evaluable patients, MET expression was significantly associated with MET amplification (P < 0.001); all MET-amplified tumor samples showed some MET expression. In 96 evaluable patients, p-MET positivity was significantly associated with MET amplification (P < 0.001). Further evaluation in larger and independent sample sets is warranted to confirm our findings. (C) 2015 AACR.

语种英语
WOS记录号WOS:000364592000023
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53058
专题北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位1.Amgen Inc, Biostat Sci, Shanghai, Peoples R China
2.Amgen Inc, Mol Sci, Thousand Oaks, CA 91320 USA
3.Amgen Inc, Global Dev, Shanghai, Peoples R China
4.Amgen Inc, Med Dept, Shanghai, Peoples R China
5.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Beijing 100871, Peoples R China
6.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Peng, Zhi,Li, Zhongwu,Gao, Jing,et al. Tumor MET Expression and Gene Amplification in Chinese Patients with Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer[J]. MOLECULAR CANCER THERAPEUTICS,2015,14(11):2634-2641.
APA Peng, Zhi.,Li, Zhongwu.,Gao, Jing.,Lu, Ming.,Gong, Jifang.,...&Shen, Lin.(2015).Tumor MET Expression and Gene Amplification in Chinese Patients with Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer.MOLECULAR CANCER THERAPEUTICS,14(11),2634-2641.
MLA Peng, Zhi,et al."Tumor MET Expression and Gene Amplification in Chinese Patients with Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer".MOLECULAR CANCER THERAPEUTICS 14.11(2015):2634-2641.
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