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Effects of Stress on Decision-Making Deficits in Formerly Heroin-Dependent Patients After Different Durations of Abstinence
Zhang, Xiao-li1; Shi, Jie1; Zhao, Li-yan1; Sun, Li-li1; Wang, Jun1; Wang, Gui-bin1; Epstein, David H.1; Lu, Lin1
刊名AMERICAN JOURNAL OF PSYCHIATRY
2011-06-01
DOI10.1176/appi.ajp.2010.10040499
168期:6页:610-616
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
资助者National Basic Research Program of China ; Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality ; National Basic Research Program of China ; Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
研究领域[WOS]Psychiatry
关键词[WOS]VENTROMEDIAL PREFRONTAL CORTEX ; ORBITOFRONTAL CORTEX ; COCAINE DEPENDENCE ; STRIA TERMINALIS ; BED NUCLEUS ; ADDICTION ; RESPONSES ; EMOTION ; ABUSERS ; VULNERABILITY
英文摘要

Objective: Drug abuse is associated with substantial impairments in decision making. However, little is known about the time course of changes in decision-making ability after abstinence or about the effects of stress on decision making in individuals recovering from heroin dependence after different durations of abstinence.

Method: First, the authors assessed decision-making performance with the original card version of the Iowa Gambling Task in formerly heroin-dependent patients who had been abstinent for 3, 7, 15, or 30 days or 3, 6, 12, or 24 months. Second, patients who had been abstinent from heroin for 15 or 30 days or 3, 12, or 24 months were challenged with acute stress induced by the Trier Social Stress Test. Third, the beta-adrenoceptor antagonist propranolol (40 mg) was administered 1 hour before stress to those who had been abstinent for 30 days or 12 or 24 months.

Results: The short-term abstinence groups (3-30 days) performed worse on the Iowa Gambling Task compared with the long-term abstinence groups (3-24 months). Psychosocial stress unmasked a latent impairment in decision making in the 24-month abstinence group, which seemed to perform identically to healthy comparison subjects in the absence of stress. Propranolol blocked the stress-induced impairment of decision making, which was seen only in the formerly heroin-dependent patients.

Conclusions: Stress can exacerbate an already existing impairment of decision making or unmask a latent one in individuals recovering from heroin dependence. The beta-adrenergic blockade reduces this effect and might hold promise for treatment of substance use disorders.

语种英语
所属项目编号2009CB522000 ; 30725016 ; 09G0762 ; 7092058
资助者National Basic Research Program of China ; Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality ; National Basic Research Program of China ; Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
WOS记录号WOS:000291242900009
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53060
专题中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA
推荐引用方式
GB/T 7714
Zhang, Xiao-li,Shi, Jie,Zhao, Li-yan,et al. Effects of Stress on Decision-Making Deficits in Formerly Heroin-Dependent Patients After Different Durations of Abstinence[J]. AMERICAN JOURNAL OF PSYCHIATRY,2011,168(6):610-616.
APA Zhang, Xiao-li.,Shi, Jie.,Zhao, Li-yan.,Sun, Li-li.,Wang, Jun.,...&Lu, Lin.(2011).Effects of Stress on Decision-Making Deficits in Formerly Heroin-Dependent Patients After Different Durations of Abstinence.AMERICAN JOURNAL OF PSYCHIATRY,168(6),610-616.
MLA Zhang, Xiao-li,et al."Effects of Stress on Decision-Making Deficits in Formerly Heroin-Dependent Patients After Different Durations of Abstinence".AMERICAN JOURNAL OF PSYCHIATRY 168.6(2011):610-616.
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