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学科主题基础医学
Cytochrome P450 gene polymorphisms and risk of low birth weight
Chen, DF1; Hu, YH1; Yang, F1; Li, ZP1; Wu, BY1; Fang, Z1; Li, JP1; Wang, LH1
关键词low birth weight cytochrome P450 log-linear modeling triads
刊名GENETIC EPIDEMIOLOGY
2005-05-01
DOI10.1002/jepi.20067
28期:4页:368-375
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Public, Environmental & Occupational Health
研究领域[WOS]Genetics & Heredity ; Public, Environmental & Occupational Health
关键词[WOS]S-TRANSFERASE-THETA ; LUNG-CANCER ; SPONTANEOUS-ABORTION ; CIGARETTE-SMOKING ; SUSCEPTIBILITY ; GENOTYPE ; EXPOSURES ; SOLVENTS ; DELETION
英文摘要

This study investigated the association between polymorphisms in cytochrome P450 genes (Cyp1A1MspI, CYP1A1HincII, and CYP2E1) and low birth weight. Between July 1999 and June 2002, we conducted a study using infant-parents triads in Anqing, China. The analyses included the families of 248 normal birth weight, full-term infants, and 248 low-birth-weight infants. Genotyping was performed for the polymorphisms of cytochrome P450 genes using standard techniques. We used log-linear modeling to analyze the association of CYP1A1 and CYP2E1 gene polymorphisms with the risk of low birth weight. In the analysis of children′s genotypes, the relative risk was 1.92 (95 % confidence interval: 1.05, 3.52, p = 0.034) for CYP1A1Mspl C/C6235 compared with CYP1A1 MspI T/T6235. In the analysis of mothers′ genotypes, an association was also seen for maternal CYP1A1MspI C/C6235 compared with CYP1A1MspI T/T6235 (relative risk: 1.68, 95 % confidence interval: 1.06, 2.68, p = 0.029). We did not observe a joint effect between mother′s and children′s genotypes. Analysis of control triads suggests Mendelian transmissions of the variant alleles of CYP1A1MspI, CYP1A1HincII, and CYP2E1. In conclusion, both infant and maternal CYP1A1MspI C/C6235 genotypes were associated with increased risk of low birth weight in our study population. This suggests a possible role for human cytochrome P450 variability in the etiology of low birth weight. (c) 2005 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000228573700007
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被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/53062
专题北京大学基础医学院_医学遗传学系
北京大学基础医学院
北京大学第一临床医学院_心血管内科
北京大学第三临床医学院_心血管内科
北京大学临床肿瘤学院_麻醉科
作者单位1.Peking Univ, First Hosp, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Ctr Ecogenet & Reprod Hlth, Dept Med Genet, Beijing 100083, Peoples R China
3.Peking Univ, Ctr Hlth Sci, Dept Epidemiol & Stat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, DF,Hu, YH,Yang, F,et al. Cytochrome P450 gene polymorphisms and risk of low birth weight[J]. GENETIC EPIDEMIOLOGY,2005,28(4):368-375.
APA Chen, DF.,Hu, YH.,Yang, F.,Li, ZP.,Wu, BY.,...&Wang, LH.(2005).Cytochrome P450 gene polymorphisms and risk of low birth weight.GENETIC EPIDEMIOLOGY,28(4),368-375.
MLA Chen, DF,et al."Cytochrome P450 gene polymorphisms and risk of low birth weight".GENETIC EPIDEMIOLOGY 28.4(2005):368-375.
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