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Associations of apolipoprotein E and low-density lipoprotein receptor-related protein 5 polymorphisms with dyslipidemia and generalized aggressive periodontitis in a Chinese population
Gao, H.; Tian, Y.; Meng, H.; Hou, J.; Xu, L.; Zhang, L.; Shi, D.; Lu, R.; Feng, X.; Wang, X.; Chen, Z.
关键词Apolipoprotein e Generalized Aggressive Periodontitis Low-density LipoProtein Receptor-related Protein 5 Serum Lipid Single Nucleotide Polymorphisms
刊名JOURNAL OF PERIODONTAL RESEARCH
2015-08-01
DOI10.1111/jre.12237
50期:4页:509-518
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]BONE-MINERAL DENSITY ; E GENE POLYMORPHISM ; LIPOPROTEIN-RECEPTOR-RELATED-PROTEIN-5 LRP5 GENE ; C-REACTIVE PROTEIN ; SYSTEMIC INFLAMMATION ; ALZHEIMERS-DISEASE ; TRANSPORT PROTEIN ; APOE POLYMORPHISM ; LIPID PROFILE ; RISK
英文摘要

Background and ObjectiveDyslipidemia is associated with aggressive periodontitis, a condition characterized by the rapid destruction of the periodontium. Apolipoprotein E (APOE) and low-density lipoprotein receptor-related protein 5 (LRP5) are involved in immunomodulation and inflammatory activity. We evaluated the association of LRP5 and APOE polymorphisms with serum lipid concentrations and generalized aggressive periodontitis within a Chinese population.

Material and MethodsMean serum lipid concentrations were compared across LRP5 and APOE polymorphisms, among cases (n=185) and controls (n=138). Multivariable logistic regression was used to evaluate the independent and combined associations of LRP5 and APOE polymorphisms with generalized aggressive periodontitis.

ResultsCompared with controls, individuals with generalized aggressive periodontitis exhibited significantly lower serum total cholesterol (TC) and lower high-density lipoprotein cholesterol (HDL-c). Individuals with LRP5 polymorphisms (rs682429-AA or rs312016-GG) exhibited higher TC, higher HDL-c and decreased odds for generalized aggressive periodontitis. Haplotype (A-G), determined by rs682429 and rs312016, was also associated with decreased odds for generalized aggressive periodontitis. Furthermore, individuals with the combined polymorphisms (LRP5-rs682429-AA and APOE-rs429358-CC/CT) had higher levels of low-density lipoprotein cholesterol, higher levels of TC and decreased odds for generalized aggressive periodontitis.

ConclusionIndependently or combined with APOE, LRP5 polymorphisms may lead to dyslipidemia and are associated with generalized aggressive periodontitis. Dyslipidemia may be a risk indicator for generalized aggressive periodontitis in the Chinese population. Furthermore, two LRP5 polymorphisms (rs682429 and rs312016) might be useful for identifying subjects at higher risk of generalized aggressive periodontitis.

语种英语
WOS记录号WOS:000357696900011
项目编号30471882 ; 30973319 ; 81271149 ; 2007BAI18B02
资助机构National Natural Science Foundations of China, Beijing, China ; National Key Project of Scientific and Technical Supporting Programs of China, Beijing, China ; Key Program of Clinical Specialty, National Ministry of Health P.R.C., Beijing, China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53065
专题北京大学口腔医学院_牙周科
北京大学第一临床医学院_检验科
北京大学第一临床医学院_输血科
北京大学第二临床医学院_眼科
北京大学第三临床医学院_妇产科
北京大学第三临床医学院_麻醉科
北京大学第三临床医学院_内分泌科
作者单位Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Gao, H.,Tian, Y.,Meng, H.,et al. Associations of apolipoprotein E and low-density lipoprotein receptor-related protein 5 polymorphisms with dyslipidemia and generalized aggressive periodontitis in a Chinese population[J]. JOURNAL OF PERIODONTAL RESEARCH,2015,50(4):509-518.
APA Gao, H..,Tian, Y..,Meng, H..,Hou, J..,Xu, L..,...&Chen, Z..(2015).Associations of apolipoprotein E and low-density lipoprotein receptor-related protein 5 polymorphisms with dyslipidemia and generalized aggressive periodontitis in a Chinese population.JOURNAL OF PERIODONTAL RESEARCH,50(4),509-518.
MLA Gao, H.,et al."Associations of apolipoprotein E and low-density lipoprotein receptor-related protein 5 polymorphisms with dyslipidemia and generalized aggressive periodontitis in a Chinese population".JOURNAL OF PERIODONTAL RESEARCH 50.4(2015):509-518.
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