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学科主题: 口腔医学
题名:
Associations of apolipoprotein E and low-density lipoprotein receptor-related protein 5 polymorphisms with dyslipidemia and generalized aggressive periodontitis in a Chinese population
作者: Gao, H.; Tian, Y.; Meng, H.; Hou, J.; Xu, L.; Zhang, L.; Shi, D.; Lu, R.; Feng, X.; Wang, X.; Chen, Z.
关键词: apolipoprotein E ; generalized aggressive periodontitis ; low-density lipoprotein receptor-related protein 5 ; serum lipid ; single nucleotide polymorphisms
刊名: JOURNAL OF PERIODONTAL RESEARCH
发表日期: 2015-08-01
DOI: 10.1111/jre.12237
卷: 50, 期:4, 页:509-518
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: BONE-MINERAL DENSITY ; E GENE POLYMORPHISM ; LIPOPROTEIN-RECEPTOR-RELATED-PROTEIN-5 LRP5 GENE ; C-REACTIVE PROTEIN ; SYSTEMIC INFLAMMATION ; ALZHEIMERS-DISEASE ; TRANSPORT PROTEIN ; APOE POLYMORPHISM ; LIPID PROFILE ; RISK
英文摘要:

Background and ObjectiveDyslipidemia is associated with aggressive periodontitis, a condition characterized by the rapid destruction of the periodontium. Apolipoprotein E (APOE) and low-density lipoprotein receptor-related protein 5 (LRP5) are involved in immunomodulation and inflammatory activity. We evaluated the association of LRP5 and APOE polymorphisms with serum lipid concentrations and generalized aggressive periodontitis within a Chinese population.

Material and MethodsMean serum lipid concentrations were compared across LRP5 and APOE polymorphisms, among cases (n=185) and controls (n=138). Multivariable logistic regression was used to evaluate the independent and combined associations of LRP5 and APOE polymorphisms with generalized aggressive periodontitis.

ResultsCompared with controls, individuals with generalized aggressive periodontitis exhibited significantly lower serum total cholesterol (TC) and lower high-density lipoprotein cholesterol (HDL-c). Individuals with LRP5 polymorphisms (rs682429-AA or rs312016-GG) exhibited higher TC, higher HDL-c and decreased odds for generalized aggressive periodontitis. Haplotype (A-G), determined by rs682429 and rs312016, was also associated with decreased odds for generalized aggressive periodontitis. Furthermore, individuals with the combined polymorphisms (LRP5-rs682429-AA and APOE-rs429358-CC/CT) had higher levels of low-density lipoprotein cholesterol, higher levels of TC and decreased odds for generalized aggressive periodontitis.

ConclusionIndependently or combined with APOE, LRP5 polymorphisms may lead to dyslipidemia and are associated with generalized aggressive periodontitis. Dyslipidemia may be a risk indicator for generalized aggressive periodontitis in the Chinese population. Furthermore, two LRP5 polymorphisms (rs682429 and rs312016) might be useful for identifying subjects at higher risk of generalized aggressive periodontitis.

语种: 英语
所属项目编号: 30471882 ; 30973319 ; 81271149 ; 2007BAI18B02
项目资助者: National Natural Science Foundations of China, Beijing, China ; National Key Project of Scientific and Technical Supporting Programs of China, Beijing, China ; Key Program of Clinical Specialty, National Ministry of Health P.R.C., Beijing, China
WOS记录号: WOS:000357696900011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53065
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100081, Peoples R China

Recommended Citation:
Gao, H.,Tian, Y.,Meng, H.,et al. Associations of apolipoprotein E and low-density lipoprotein receptor-related protein 5 polymorphisms with dyslipidemia and generalized aggressive periodontitis in a Chinese population[J]. JOURNAL OF PERIODONTAL RESEARCH,2015,50(4):509-518.
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