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学科主题临床医学
A Retrospective Study of Coagulation Abnormalities in Patients Receiving Cefoperazone Sodium and Sulbactam Sodium
Ge, Hong-Xia1; Wang, Yong-Jian2; Ning, Lin-Hong3; Zhao, Qing-Ying4; Li, Nan5; Ma, Qing-Bian1
关键词Cefoperazone Sodium And Sulbactam Sodium Prothrombin Time Prolongation Parenteral Nutrition Antibiotic Vitamin K-1
刊名JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS
2015-08-01
DOI10.1166/jmihi.2015.1451
5期:4页:765-768
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mathematical & Computational Biology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Mathematical & Computational Biology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]HYPOPROTHROMBINEMIA ; THERAPY
英文摘要

Objective: The study was to investigate the risk factors for coagulopathy and countermeasures during cefoperazone sodium and sulbactam sodium (CPZ-SBT) injection, which could provide scientific reference for the safety of clinical rational drug use. Methods: In our study, 79 patients that have been diagnosed with pneumonia were treated with CPZ-SBT and retrospectively investigated for duration of one year. Records of these patients were reviewed for age, sex, underlying disease, albumin, alanine transaminase, total bilirubin, prothrombin time (PT), nutritional approach, prognosis, hospitalization duration, additional antibiotics and hemorrhage. Results: PT prolongation occurred in 30 out of 79 patients (38.0%). The rate of PT prolongation was significantly higher in the patients with total parenteral nutrition than enteral nutrition (62% vs. 38%, P = 0.009). It was more common in patients receiving antibiotics combinations than single CPZ-SBT (44.3% vs. 16.7%, P = 0.034). In addition, synergistic effect appeared in patients with total parenteral nutrition and combined with antibiotics (P = 0.003). Positive stool occult test and positive gastric juice occult test were significantly different (25.3% vs. 12.1%, P = 0.001; 29.1% vs. 8.9%, P = 0.002, respectively). PT was prolonged for 6.6 +/- 3.6 days after initiation of CPZ-SBT injection, and rapidly returned to normal in all patients treated with vitamin K-1, after 1.4 +/- 0.9 days. Conclusion: PT prolongation was susceptible to parenteral nutrition and share antibiotics for the patients treated with CPZ-SBT. The coagulopathy could be reversed by an intramuscular injection of 10 mg/d vitamin K-1. We recommend daily intramuscular injection vitamin K-1 for these patients.

语种英语
WOS记录号WOS:000358625600015
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53069
专题北京大学第三临床医学院_急诊科
作者单位1.Peking Univ, Hosp 3, Emergency Dept, Beijing 100191, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Emergency, Haidian 518036, Shenzhen Provin, Peoples R China
3.Armed Police Corps Hosp Shanxi Prov, Dept Emergency, Taiyuan 030006, Shanxi, Peoples R China
4.Changping Hosp Integrated Chinese & Western Med, Dept Emergency, Beijing 102208, Peoples R China
5.Peking Univ, Hosp 3, Clin Epidemiol Res Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ge, Hong-Xia,Wang, Yong-Jian,Ning, Lin-Hong,et al. A Retrospective Study of Coagulation Abnormalities in Patients Receiving Cefoperazone Sodium and Sulbactam Sodium[J]. JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS,2015,5(4):765-768.
APA Ge, Hong-Xia,Wang, Yong-Jian,Ning, Lin-Hong,Zhao, Qing-Ying,Li, Nan,&Ma, Qing-Bian.(2015).A Retrospective Study of Coagulation Abnormalities in Patients Receiving Cefoperazone Sodium and Sulbactam Sodium.JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS,5(4),765-768.
MLA Ge, Hong-Xia,et al."A Retrospective Study of Coagulation Abnormalities in Patients Receiving Cefoperazone Sodium and Sulbactam Sodium".JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS 5.4(2015):765-768.
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