IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Molecular targeted agents-where we are and where we are going
Yan, Li1,2,3
关键词Targeted Agents Cancer
刊名CHINESE JOURNAL OF CANCER
2013-05-01
DOI10.5732/cjc.013.10051
32期:5页:225-232
收录类别SCI
文章类型Editorial Material
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]BREAST-CANCER ; MELANOMA ; SAFETY ; BRAF
英文摘要

A total of 23 new cancer medicines or indication expansions were approved by the U. S. Food and Drug Administration in 2012. Among these, 12 are new molecular entities (NMEs)-new chemical or biological drugs approved for the first time for oncologic use-and 10 of these NMEs are molecular targeted agents. Among the 10 targeted agents, 4 are anti-angiogenesis agents and 2 are Bcr-Abl pathway inhibitors, targeting well established targets validated by previously approved agents such as bevacizumab (Avastin) or imatinib (Gleevec). Despite this progress, several questions remain: Do these newly approved agents provide sufficient treatment options to manage the broad spectrum of cancers we deal with in the clinic? Where will the next wave of new cancer drugs come from? Where should R&D efforts be invested to continue improve cancer treatment and management, especially for tumor types uniquely prevalent in China? This editorial and the review articles in this special issue of Chinese Journal of Cancer provide an in depth review of the progress and challenges in developing targeted cancer therapies, as well as an outlook of new research areas where near term breakthroughs are expected to overcome some of these challenges.

语种英语
WOS记录号WOS:000339649700001
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53072
Collection北京大学临床肿瘤学院
作者单位1.Merck & Co Inc, N Wales, PA 19454 USA
2.US Chinese Anticanc Assoc, Los Angeles, CA 90036 USA
3.Peking Univ, Beijing Canc Hosp, Sch Oncol, Canc Hosp, Beijing 100142, Peoples R China
Recommended Citation
GB/T 7714
Yan, Li. Molecular targeted agents-where we are and where we are going[J]. CHINESE JOURNAL OF CANCER,2013,32(5):225-232.
APA Yan, Li.(2013).Molecular targeted agents-where we are and where we are going.CHINESE JOURNAL OF CANCER,32(5),225-232.
MLA Yan, Li."Molecular targeted agents-where we are and where we are going".CHINESE JOURNAL OF CANCER 32.5(2013):225-232.
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