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Intraoperative detection of sentinel lymph node metastases inbreast carcinoma by Fourier transform infrared spectroscopy
Tian, P.1; Zhang, W.1; Zhao, H.1; Lei, Y.1; Cui, L.1; Zhang, Y.2; Xu, Z.1
刊名BRITISH JOURNAL OF SURGERY
2015-10-01
DOI10.1002/bjs.9882
102期:11页:1372-1379
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]BREAST-CANCER ; THYROID-CARCINOMA ; BIOPSY ; ACCURACY ; UPDATE ; TISSUE
英文摘要

BackgroundSentinel lymph node (SLN) biopsy is a routine surgical staging procedure in clinically lymph node-negative breast cancer. Fourier transform infrared (FTIR) spectroscopy, a technique based on the biochemical composition of the tissue, has previously been found to be capable of differentiating between normal and malignant tissue. The aim of the present study was to explore the intraoperative use of FTIR spectroscopy for rapidly identifying metastatic SLNs, and distinguishing between metastatic and non-metastatic tissue.

MethodsFreshly removed SLNs from patients with breast cancer were analysed. Samples were measured by FTIR spectroscopy before histopathological diagnosis. The FTIR spectrum of each sample identified ten bands from 2000 to 900cm(-1). The peak position, intensity and full width at half maximum of each absorbent band were measured, and the relative intensity ratios calculated. Canonical discriminant analysis was performed to discriminate between metastatic and non-metastatic samples.

ResultsA total of 149 SLNs were removed from 49 patients. Histopathological examination confirmed 38 metastatic and 111 non-metastatic SLNs. Eighteen of 29 parameters were significantly different between the metastatic and non-metastatic SLNs. Five parameters were selected as independent factors to form discriminant functions. The sensitivity, specificity and accuracy of this method were 947, 901 and 913 per cent respectively. The accuracy of histological analysis of frozen sections was 100 per cent.

Conclusion: FTIR spectroscopy is a promising technique for the real-time diagnosis of SLN metastasis during breast cancer surgery.

语种英语
WOS记录号WOS:000361228000010
项目编号2122059 ; B59427-01 ; BYSY201207
资助机构Beijing Rayleigh Analytical Instrument Corporation (Beijing, China) ; Beijing Natural Science Foundation ; Clinical Research Project of Peking University Third Hospital ; Peking University Third Hospital
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53084
专题北京大学第三临床医学院_普通外科
北京大学第一临床医学院_小儿外科
作者单位1.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Tian, P.,Zhang, W.,Zhao, H.,et al. Intraoperative detection of sentinel lymph node metastases inbreast carcinoma by Fourier transform infrared spectroscopy[J]. BRITISH JOURNAL OF SURGERY,2015,102(11):1372-1379.
APA Tian, P..,Zhang, W..,Zhao, H..,Lei, Y..,Cui, L..,...&Xu, Z..(2015).Intraoperative detection of sentinel lymph node metastases inbreast carcinoma by Fourier transform infrared spectroscopy.BRITISH JOURNAL OF SURGERY,102(11),1372-1379.
MLA Tian, P.,et al."Intraoperative detection of sentinel lymph node metastases inbreast carcinoma by Fourier transform infrared spectroscopy".BRITISH JOURNAL OF SURGERY 102.11(2015):1372-1379.
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