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IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科  > 期刊论文
学科主题: 临床医学
题名:
Black Yeasts and Their Filamentous Relatives: Principles of Pathogenesis and Host Defense
作者: Seyedmousavi, Seyedmojtaba1,2,3; Netea, Mihai G.4; Mouton, Johan W.1,2; Melchers, Willem J. G.1; Verweij, Paul E.1; de Hoog, G. Sybren5,6,7,8,9
刊名: CLINICAL MICROBIOLOGY REVIEWS
发表日期: 2014-07-01
DOI: 10.1128/CMR.00093-13
卷: 27, 期:3, 页:527-542
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: WANGIELLA EXOPHIALA DERMATITIDIS ; INVASIVE FUNGAL-INFECTIONS ; MITOCHONDRIAL-DNA ANALYSIS ; DIFFERENT CLINICAL FORMS ; LETHARGIC CRAB DISEASE ; V CHITIN SYNTHASE ; FONSECAEA-PEDROSOI ; SUBCUTANEOUS PHEOHYPHOMYCOSIS ; CEREBRAL PHEOHYPHOMYCOSIS ; DENDRITIC CELLS
英文摘要:

Among the melanized fungi, the so-called "black yeasts" and their filamentous relatives are particularly significant as agents of severe phaeohyphomycosis, chromoblastomycosis, and mycetoma in humans and animals. The pathogenicity and virulence of these fungi may differ significantly between closely related species. The factors which probably are of significance for pathogenicity include the presence of melanin and carotene, formation of thick cell walls and meristematic growth, presence of yeast-like phases, thermo-and perhaps also osmotolerance, adhesion, hydrophobicity, assimilation of aromatic hydrocarbons, and production of siderophores. Host defense has been shown to rely mainly on the ingestion and elimination of fungal cells by cells of the innate immune system, especially neutrophils and macrophages. However, there is increasing evidence supporting a role of T-cell-mediated immune responses, with increased interleukin-10 (IL-10) and low levels of gamma interferon (IFN-gamma) being deleterious during the infection. There are no standardized therapies for treatment. It is therefore important to obtain in vitro susceptibilities of individual patients′ fungal isolates in order to provide useful information for selection of appropriate treatment protocols. This article discusses the pathogenesis and host defense factors for these fungi and their severity, chronicity, and subsequent impact on treatment and prevention of diseases in human or animal hosts.

语种: 英语
项目资助者: Netherlands Organization for Scientific Research ; Astellas ; Basilea ; Gilead Sciences ; Merck ; Pfizer
WOS记录号: WOS:000338833000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53092
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Radboudumc, Dept Internal Med, Nijmegen, Netherlands
2.CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands
3.King Abdulaziz Univ, Jeddah 21413, Saudi Arabia
4.Radboudumc, Dept Med Microbiol, Nijmegen, Netherlands
5.Mazandaran Univ Med Sci, Invas Fungi Res Ctr, Sari, Iran
6.Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
7.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
8.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
9.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China

Recommended Citation:
Seyedmousavi, Seyedmojtaba,Netea, Mihai G.,Mouton, Johan W.,et al. Black Yeasts and Their Filamentous Relatives: Principles of Pathogenesis and Host Defense[J]. CLINICAL MICROBIOLOGY REVIEWS,2014,27(3):527-542.
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