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学科主题: 临床医学
题名:
Risk Factors of Pulmonary Thrombosis/Embolism in Nephrotic Syndrome
作者: Yang, Yihe1,2,3,4; Lv, Jicheng1,2,3,4; Zhou, Fude1,2,3,4; Chen, Min1,2,3,4; Wang, Rongfu5; Zhao, Minghui2,3,4; Wang, Haiyan1,2,3,4
关键词: Risk Factors ; Pulmonary Thrombosis ; Embolism ; Nephrotic Syndrome
刊名: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
发表日期: 2014-11-01
卷: 348, 期:5, 页:394-398
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: RENAL-VEIN THROMBOSIS ; THROMBOEMBOLIC EVENTS ; MEMBRANOUS NEPHROPATHY ; VENOUS THROMBOEMBOLISM ; D-DIMER ; EMBOLISM ; COMPLICATIONS ; EXCLUSION ; OUTCOMES
英文摘要:

Background: Nephrotic syndrome is associated with an increased risk for thromboembolic complications. Until now, few studies have ever specified the risk of pulmonary thrombosis/embolism (PTE) in patients with nephrotic syndrome. In this study, we assessed the risk of PTE in a large cross-sectional study to identify risk factors in this population. Methods: Three hundred twelve patients with NS who had screened PTE through lung ventilation-perfusion scan were collected and analyzed. Multivariate Logistic regression was used to detect the independent risk factors for PTE. Logistic regression was used to identify the threshold value of D-dimer. Results: Sixty-five patients (20.8%) had PTE in individuals with NS. Elevated level of plasma D-dimer was identified as an independent risk factor of PTE on multivariate analysis (odds ratio 5 1.54; 95% confidence interval: 1.27-1.88). While proteinuria at presentation and serum albumin were not associated with PTE after adjusted for D-dimer (P>0.05). The cumulative probability of PTE was in a nearly linear association with the plasma D-dimer level even within the normal range. Based on the plasma D-dimer level, we had developed a concise model to predict the risk of pulmonary embolism using logistic curve. Conclusions: In adult patients with NS, high level of plasma D-dimer was closely associated with PTE, whereas proteinuria or serum albumin level was not in this study. Using plasma D-dimer level, we developed a concise model to predict the risk of PTE.

语种: 英语
WOS记录号: WOS:000344608400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53094
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Div Renal, Beijing 100871, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100871, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Dept Nucl Med, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Yihe,Lv, Jicheng,Zhou, Fude,et al. Risk Factors of Pulmonary Thrombosis/Embolism in Nephrotic Syndrome[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2014,348(5):394-398.
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