IR@PKUHSC  > 北京大学第二临床医学院  > 肾内科
学科主题临床医学
Ultrastructural pathological features of unilateral renal artery stenosis in the rats
Liu, Xin1,2; Mao, Yonghui2; He, Xuemei2; Wang, Mei1; Gan, Liangying1
关键词Renal Artery Stenosis Kidney Crescent Formation Podocytes
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2015
8期:5页:4807-4814
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]CRESCENTIC GLOMERULONEPHRITIS ; COLLAPSING GLOMERULOPATHY ; PODOCYTES ; HYPERTENSION ; HYPOXIA ; INJURY ; MODEL
英文摘要

Renal artery stenosis (RAS) is one of the main reasons of renovascular hypertension and its pathogenesis remains unclear. In this study, we aimed to investigate histopathological characteristics in a rat model of RAS. Sprague-Dawley (SD) male rats were randomly divided into unilateral RAS group (Model group, n = 30) and Sham group (n = 30). The left renal artery was clamped with miniature silver clip for the rats in RAS group, while it was exposed but not clamped for the rats in Sham group. After the surgery, the rats were randomly divided into ten subgroups based on the time after surgery (n = 3). Blood pressure, urinary albumin/creatinine ratio, and serum albumin and creatinine levels were measured. The kidneys were dissected for histological and electron microscopy analysis. The results showed that systolic blood pressure was significantly higher since 4 weeks after surgery compared to before surgery. There were no significant differences in urinary albumin/creatinine ratio as well as serum albumin and creatinine levels in Model and Sham groups. During the early acute renal ischemia the stenotic kidney exhibited acute tubular injury, podocyte injury and some crescent formation, and the main components of crescent are podocytes. Although renal tubules and vascular lesions gradually recover and crescent disappears, segmental lesions of podocyte appear in the late stage of RAS. These data reveal ultrastructural pathological changes during RAS, and suggest the role of podocyte lesions in chronic renal ischemia.

语种英语
WOS记录号WOS:000358370300052
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53095
专题北京大学第二临床医学院_肾内科
作者单位1.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Dept Nephrol, Beijing 100044, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Beijing Hosp, Dept Nephrol, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714
Liu, Xin,Mao, Yonghui,He, Xuemei,et al. Ultrastructural pathological features of unilateral renal artery stenosis in the rats[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2015,8(5):4807-4814.
APA Liu, Xin,Mao, Yonghui,He, Xuemei,Wang, Mei,&Gan, Liangying.(2015).Ultrastructural pathological features of unilateral renal artery stenosis in the rats.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,8(5),4807-4814.
MLA Liu, Xin,et al."Ultrastructural pathological features of unilateral renal artery stenosis in the rats".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8.5(2015):4807-4814.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Xin]的文章
[Mao, Yonghui]的文章
[He, Xuemei]的文章
百度学术
百度学术中相似的文章
[Liu, Xin]的文章
[Mao, Yonghui]的文章
[He, Xuemei]的文章
必应学术
必应学术中相似的文章
[Liu, Xin]的文章
[Mao, Yonghui]的文章
[He, Xuemei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。