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Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population
Liu, H. C.1; Zhang, J.1; Wong, S.1; Han, D.1; Zhao, H. S.2,3; Feng, H. L.1
关键词Single Nucleotide Polymorphism Tooth Agenesis Case-control Study Dkk1
刊名GENETICS AND MOLECULAR RESEARCH
2014
DOI10.4238/2014.April.3.4
13期:3页:7133-7139
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]PROTEIN-2 AXIN2 POLYMORPHISMS ; GENETIC-BASIS ; ISOLATED HYPODONTIA ; DENTAL AGENESIS ; MUTATIONS ; MALFORMATIONS ; OLIGODONTIA ; ANOMALIES ; DEFECTS ; WNT10A
英文摘要

Tooth agenesis is one of the most common anomalies of human dentition. Recent genetic studies have provided information regarding a number of genes related to both syndromic and non-syndromic forms of hypodontia. In a previous study, we found that polymorphism in rs11001553 of DKK1 was associated with hypodontia in the Chinese Han population. In this study, we extended this investigation to 89 individuals diagnosed with sporadic non-syndromic oligodontia (40 males and 49 females). These individuals were analyzed with 268 subjects (123 males and 145 females) diagnosed with non-syndromic hypodontia and 190 healthy control subjects (99 males and 91 females). DNA was obtained from whole blood or saliva samples and genotyping was performed by matrix-assisted laser desorption ionization-time of flight mass spectrometry. Significant differences were observed in the allele and genotype frequencies of rs11001553 of DKK1. These data demonstrated an association between rs11001553 of DKK1, a tooth development-associated gene, and non-syndromic tooth agenesis in Chinese Han individuals. This information may provide further understanding of the molecular mechanisms of tooth agenesis. Furthermore, DKK1 can be regarded as a marker gene for the risk of tooth agenesis.

语种英语
WOS记录号WOS:000343049600078
项目编号7092113 ; 81070814 ; 81100725 ; 2007-1005
资助机构Beijing Natural Science Foundation ; National Natural Science Foundation ; Capital Medical Developing Foundation
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53101
专题北京大学口腔医学院_口腔修复科
北京大学第一临床医学院_泌尿外科
北京大学口腔医学院_材料检测中心
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Genet, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Ctr Human Dis Genom, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, H. C.,Zhang, J.,Wong, S.,et al. Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population[J]. GENETICS AND MOLECULAR RESEARCH,2014,13(3):7133-7139.
APA Liu, H. C.,Zhang, J.,Wong, S.,Han, D.,Zhao, H. S.,&Feng, H. L..(2014).Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population.GENETICS AND MOLECULAR RESEARCH,13(3),7133-7139.
MLA Liu, H. C.,et al."Association between rs11001553 of DKK1 and non-syndromic tooth agenesis in the Chinese Han population".GENETICS AND MOLECULAR RESEARCH 13.3(2014):7133-7139.
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