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学科主题: 精神卫生
题名:
Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function
作者: Liao, Jinmin1,2,3; Yan, Hao1,2,3; Liu, Qi1,2,3; Yan, Jun1,2,3; Zhang, Lanlan1,2,3; Jiang, Sisi1,2,3; Zhang, Xiao1,2,3; Dong, Zheng1,2,3; Yang, Wen1,2,3; Cai, Liwei1,2,3; Guo, Huining1,2,3; Wang, Yan1,2,3; Li, Zimeng1,2,3; Tian, Lin1,2,3; Zhang, Dai1,2,3,4,5; Wang, Fei6,7
关键词: Schizophrenia ; Paralimbic system ; Structural magnetic resonance imaging ; Voxel-based morphometry
刊名: JOURNAL OF PSYCHIATRIC RESEARCH
发表日期: 2015-06-01
DOI: 10.1016/j.jpsychires.2015.04.008
卷: 65, 页:80-86
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: VOXEL-BASED MORPHOMETRY ; TEMPORAL POLE MORPHOLOGY ; ORBITOFRONTAL CORTEX ; 1ST-EPISODE SCHIZOPHRENIA ; STRUCTURAL ALTERATIONS ; ONSET SCHIZOPHRENIA ; MRI PARCELLATION ; PROCESSING SPEED ; INSULAR CORTEX ; METAANALYSIS
英文摘要:

Background: Psychopathy is associated with dysfunction in regions that compose the paralimbic system, such as the orbitofrontal cortex (OFC), insular cortex (IC), temporal pole (TP), parahippocampal gyrus (PHG) and cingulate cortex (CC). However, findings of structural alterations in these regions are inconsistent in schizophrenia, and correlations between paralimbic system measures and symptomatology and cognitive function have not been investigated.

Method: 93 patients with schizophrenia and 99 healthy controls received structural magnetic resonance imaging and clinical and cognitive assessment. We compared gray matter volume (GMV) between the two groups using voxel-based morphometry, and evaluated correlations between abnormal GMVs and clinical variables, symptomatology and cognitive function. The assessment of cognition included measures of processing speed, verbal fluency and memory.

Results: Patients with schizophrenia demonstrated significant GMV decreases in the paralimbic system, including bilateral OFC, IC and TP (p < 0.05, FWE corrected). GMV decreases were also observed in bilateral superior temporal gyri (STG). The GMVs in bilateral OFC, left IC, left TP and bilateral STG were positively correlated with processing speed, and the GMVs in bilateral OFC were positively correlated with memory function in all participants. In our patient group, the GMV deficits were also associated with earlier age of onset, longer duration of illness, greater number of hospitalizations and more severe positive symptoms.

Conclusions: GMVs in the paralimbic system were significantly reduced in schizophrenia, and these abnormalities were correlated with clinical variables, symptomatology and cognitive function. These results suggest the paralimbic system plays an important role in the pathophysiology of schizophrenia. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2011CB707805 ; 91232305 ; 81361120395 ; 91432304 ; 81370032 ; 2015BAI13801
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China ; National Key Technology R&amp ; D Program of China
WOS记录号: WOS:000356123300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53102
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA
2.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
4.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
5.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
6.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
7.China Med Univ, Affiliated Hosp 1, Dept Psychiat & Radiol, Shenyang 110001, Liaoning, Peoples R China

Recommended Citation:
Liao, Jinmin,Yan, Hao,Liu, Qi,et al. Reduced paralimbic system gray matter volume in schizophrenia: Correlations with clinical variables, symptomatology and cognitive function[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2015,65:80-86.
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