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学科主题: 临床医学
题名:
Association of Human Papillomavirus 31 DNA Load with Risk of Cervical Intraepithelial Neoplasia Grades 2 and 3
作者: Liu, Xia1,4; Schiffman, Mark3; Hulbert, Ayaka1; He, Zhonghu5; Shen, Zhenping1; Koutsky, Laura A.2; Xi, Long Fu1,2
刊名: JOURNAL OF CLINICAL MICROBIOLOGY
发表日期: 2015-11-01
DOI: 10.1128/JCM.01279-15
卷: 53, 期:11, 页:3451-3457
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: VIRAL LOAD ; NATURAL-HISTORY ; IN-SITU ; CANCER ; INFECTION ; LESIONS ; WOMEN ; CLEARANCE ; DISEASE ; INTEGRATION
英文摘要:

The association between human papillomavirus 31 (HPV31) DNA loads and the risk of cervical intraepithelial neoplasia grades 2 and 3 (CIN2-3) was evaluated among women enrolled in the atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesion (LSIL) triage study (ALTS), who were monitored semiannually over 2 years and who had HPV31 infections detected at >= 1 visit. HPV31 DNA loads in the first HPV31-positive samples and in a random set of the last positive samples from women with >= 2 HPV31-positive visits were measured by a real-time PCR assay. CIN2-3 was histologically confirmed at the same time as the first detection of HPV31 for 88 (16.6%) of 530 women. After adjustment for HPV31 lineages, coinfection with other oncogenic types, and the timing of the first positive detection, the odds ratio (OR) per 1-log-unit increase in viral loads for the risk of a concurrent diagnosis of CIN2-3 was 1.5 (95% confidence interval [CI], 1.2 to 1.9). Of 373 women without CIN2-3 at the first positive visit who had >= 1 later visit, 44 had subsequent diagnoses of CIN2-3. The initial viral loads were associated with CIN2-3 diagnosed within 6 months after the first positive visit (adjusted OR, 1.5 [95% CI, 1.0 to 2.4]) but were unrelated to CIN2-3 diagnosed later. For a random set of 49 women who were tested for viral loads at the first and last positive visits, changes in viral loads were upward and downward among women with and without follow-up CIN2-3 diagnoses, respectively, although the difference was not statistically significant. Results suggest that HPV31 DNA load levels at the first positive visit signal a short-term but not long-term risk of CIN2-3.

语种: 英语
所属项目编号: CA133569
项目资助者: National Cancer Institute, National Institutes of Health ; Plan of Cultivating Future Talents award from Shengjing Hospital, China Medical University
WOS记录号: WOS:000365626200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53103
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA
2.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA
3.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
4.China Med Univ, Shengjing Hosp, Dept Obstet & Gynecol, Liaoning, Peoples R China
5.Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China

Recommended Citation:
Liu, Xia,Schiffman, Mark,Hulbert, Ayaka,et al. Association of Human Papillomavirus 31 DNA Load with Risk of Cervical Intraepithelial Neoplasia Grades 2 and 3[J]. JOURNAL OF CLINICAL MICROBIOLOGY,2015,53(11):3451-3457.
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