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学科主题: 临床医学
题名:
A haplotype of MATN3 is associated with vertebral fracture in Chinese postmenopausal women: Peking Vertebral Fracture (PK-VF) study
作者: Zhao, Jing1; Xia, Weibo1; Nie, Min1; Zheng, Xin2; Wang, Qiuping3; Wang, Xiran4; Wang, Wenbo5; Ning, Zhiwei6; Huang, Wei7; Jiang, Yan1; Li, Mei1; Wang, Ou1; Xing, Xiaoping1; Sun, Yue1; Luo, Lianmei1; He, Shuli1; Yu, Wei8; Lin, Qiang8; Pei, Yu9; Zhang, Fan3; Han, Youxia7; Tong, Yanmin2; Che, Ying5; Shen, Ruixin10; Hu, Yingying1; Zhou, Xueying1; Chen, Qian11; Xu, Ling12
关键词: MATN3 ; BMD ; Vertebral fracture ; Bone turnover markers ; 25(OH)D
刊名: BONE
发表日期: 2012-04-01
DOI: 10.1016/j.bone.2012.01.003
卷: 50, 期:4, 页:917-924
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: BONE-MINERAL DENSITY ; MULTIPLE EPIPHYSEAL DYSPLASIA ; VON-WILLEBRAND-FACTOR ; EXTRACELLULAR-MATRIX ; MATRILIN-3 MUTATION ; COLLAGEN FIBRILS ; SOST GENE ; A-DOMAIN ; OSTEOARTHRITIS ; OSTEOPOROSIS
英文摘要:

The Matrilin3 gene (MATN3) encodes an extracellular matrix protein, which modulates chondrocyte differentiation. The aim of this study was to test for association of MATN3 polymorphisms with bone mineral density (BMD), fracture, vertebral fracture, bone turnover or 25-hydroxyvitamin D [25(OH)D] in postmenopausal women. A community-based population of 1488 postmenopausal women was randomly selected in Beijing. The history of fracture and vertebral fracture was obtained via questionnaire and vertebral X-ray respectively. BMD of lumbar spine (2-4), femoral neck and total hip were measured by dual energy X-ray absorptiometry. Serum N-terminal procollagen of type 1 collagen (P1NP), beta-isomerized type I collagen C-telopeptide breakdown products (beta-CTX) and 25(OH)D were quantified. Binary logistic regression revealed that Haplotype-4 was significantly associated with vertebral fracture risk in both additive model (p = 0.023, OR = 1.521) and dominant model (p = 0.028, OR = 1.623). The significance remained after 10.000 permutation tests to correct multiple testing (p = 0.042). Re-selected age matched vertebral fracture case-control groups revealed similar associations in additive model (p = 0.014, OR = 1.927, 95%CI = 1.142-3.253) and in dominant model (p = 0.011, OR = 2.231, 95%CI = 1.200-4.148). However, no significant association was found between MATN3 polyrnorphisms and serum beta-CTX, PI NP, 25(OH)D levels, or BMD. In linear regression, Haplotype-2 approached marginal significance in association with femoral neck BMDT-score (p = 0.050), but this would account for only 0.2% of BMD variation in our sample. This study suggests that Haplotype-4 of MATN3 is associated with vertebral fracture risk independent of BMD in Chinese postmenopausal women. Efforts should be made to replicate our finding in other, similar and ethnically diverse, populations. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2005DIB1J085 ; 2006BAI02B03 ; 81070687
项目资助者: National Special Research Foundation for the Commonweal of Society ; National Science &amp ; Technology Pillar Program ; National Natural Science Foundation of China (NSFC)
WOS记录号: WOS:000301967400015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53114
Appears in Collections:北京大学首钢医院_内分泌科_期刊论文

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作者单位: 1.China Rehabil Res Ctr, Dept Endocrinol, Beijing 100068, Peoples R China
2.Beijing Haidian Hosp, Dept Endocrinol, Beijing 100080, Peoples R China
3.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Minist Hlth, Dept Endocrinol,Key Lab Endocrinol, Beijing 100730, Peoples R China
4.Beijing Liangxiang Hosp, Dept Endocrinol, Beijing 102401, Peoples R China
5.Second Artillery Force, Gen Hosp, Dept Cadre Unit, Beijing 100088, Peoples R China
6.Peking Univ, Shougang Hosp, Dept Endocrinol, Beijing 100144, Peoples R China
7.Capital Univ Med Sci, Beijing Chaoyang Hosp, Dept Endocrinol, Beijing 100020, Peoples R China
8.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China
9.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Endocrinol, Beijing 100853, Peoples R China
10.Capital Univ Med Sci, Beijing Chaoyang Hosp, Dept Orthoped, Beijing 100020, Peoples R China
11.Brown Univ, Rhode Isl Hosp, Alpert Med Sch, Dept Orthopaed, Providence, RI 02912 USA
12.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, Beijing 100730, Peoples R China

Recommended Citation:
Zhao, Jing,Xia, Weibo,Nie, Min,et al. A haplotype of MATN3 is associated with vertebral fracture in Chinese postmenopausal women: Peking Vertebral Fracture (PK-VF) study[J]. BONE,2012,50(4):917-924.
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