IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMPs) as regulators of tumor-host interaction in a spontaneous metastasis model in rats
Carolina Donadio, Ana1; Monica Remedi, Maria1; Susperreguy, Sebastian1; Frede, Silvia1; Beatriz Gilardoni, Monica1; Tang, Yi2; Gabriela Pellizas, Claudia1; Yan, Li2,3
关键词Tumor Metastasis Emmprin Mmps Liver
刊名HISTOCHEMISTRY AND CELL BIOLOGY
2008-12-01
DOI10.1007/s00418-008-0496-6
130期:6页:1155-1164
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Microscopy
研究领域[WOS]Cell Biology ; Microscopy
关键词[WOS]CANCER PROGRESSION ; CELL INVASION ; GROWTH-FACTOR ; GELATINASE-B ; IN-VIVO ; CARCINOGENESIS ; EXPRESSION ; MATRIX-METALLOPROTEINASE-2 ; FIBROBLASTS ; INDUCTION
英文摘要

EMMPRIN has a role in invasion and metastasis through the induction of MMPs and the consequent modulation of cell-substrate and cell-cell adhesion processes. The present study evaluates the expression of EMMPRIN protein and MMP-2/9 activity in tumor and parenchymal cells in a spontaneous metastasis model in rats. Moreover, we explore the regulation of EMMPRIN and MMP-9 by tumor-epithelial cell interactions in vitro. By zymography, we observed an increased proMMP-9 expression in both metastasized liver and spleen samples from tumor bearing rats. Immunohistochemical studies showed EMMPRIN-positive tumor cells in tumor biopsies as well as in spleen and liver samples from tumor bearing rats. Interestingly, a significant increase in EMMPRIN expression in hepatic cells was also detected. The regulation of EMMPRIN expression in tumor and liver cells in response to tumor-host interaction was investigated in vitro through a tumor cell line culture on extracellular matrix ((ECM) molecules or in co-culture with normal rat liver cells (BRL3A cells). No significant changes in EMMPRIN expression were detected in tumor cells cultured on ECM molecules. On the other hand, EMMPRIN protein and MMP-9 mRNA expression were induced in BRL3A cells. The increase in EMMPRIN expression in BRL3A cells was inhibited by an anti-EMMPRIN antibody. These results reinforce the main role of EMMPRIN mediating tumor host interactions that may evolve new opportunities for therapeutic interventions.

语种英语
WOS记录号WOS:000261956400009
资助机构Secretaria de Ciencia y Tecnologia de la Universidad Nacional de Cordoba (SECyT) ; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) ; Agencia Nacional de Promocion Ciencia y Tecnica (FONCyT)
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53117
专题北京大学临床肿瘤学院
作者单位1.Centocor Inc, Malvern, PA 19355 USA
2.Univ Nacl Cordoba, CIBICI CONICET, Fac Ciencias Quim, Dept Bioquim Clin, Cordoba, Argentina
3.Peking Univ, Beijing Canc Hosp, Sch Oncol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Carolina Donadio, Ana,Monica Remedi, Maria,Susperreguy, Sebastian,et al. Extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMPs) as regulators of tumor-host interaction in a spontaneous metastasis model in rats[J]. HISTOCHEMISTRY AND CELL BIOLOGY,2008,130(6):1155-1164.
APA Carolina Donadio, Ana.,Monica Remedi, Maria.,Susperreguy, Sebastian.,Frede, Silvia.,Beatriz Gilardoni, Monica.,...&Yan, Li.(2008).Extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMPs) as regulators of tumor-host interaction in a spontaneous metastasis model in rats.HISTOCHEMISTRY AND CELL BIOLOGY,130(6),1155-1164.
MLA Carolina Donadio, Ana,et al."Extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMPs) as regulators of tumor-host interaction in a spontaneous metastasis model in rats".HISTOCHEMISTRY AND CELL BIOLOGY 130.6(2008):1155-1164.
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