|Multiple intravitreal injections of ganciclovir for cytomegalovirus retinitis after stem-cell transplantation|
|Miao, Heng; Tao, Yong; Jiang, Yan-rong; Li, Xiao-xin|
|关键词||Ganciclovir Intravitreal Injection Cytomegalovirus Retinitis Transplant|
|刊名||GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY|
|WOS标题词||Science & Technology|
|关键词[WOS]||DISEASE ; AIDS|
Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in patients after hematopoietic stem cell transplantation (HSCT). Although much effort has been put into dealing with CMV retinitis secondary to acquired immunodeficiency syndrome (AIDS), the few reports which have been published have mainly focused on treatment of CMVR after HSCT.
This clinical interventional retrospective study included 14 patients (eight men; mean age 23.89 +/- 12.09; 23 eyes) who suffered from CMV retinitis after stem-cell transplantation, in order to evaluate the efficacy and safety of multiple intravitreal injections of ganciclovir (IVG) for patients with CMV retinitis. All patients received 4 injections of IVG of 1 mg at 1 week intervals, and were followed up weekly for at least 2 months with measurement of best-corrected visual acuity (BCVA) and CMV levels in anterior aqueous humor with real-time polymerase chain reaction. Anterior aqueous humor was obtained before each injection.
The levels of CMV in anterior aqueous humor showed significant decrease from (6.34 +/- 15.78) x 10(5) copies/ml at baseline to (5.22 +/- 12.15) x 10(3) copies/ml at 1 month (P < 0.001, Mann-Whitney U test). CMV couldn′t be detected in 11 eyes (47.8 %) after two injections, and this rose to 18 eyes (78.3 %) at 1 month. The mean logMAR BCVA was 0.659 +/- 0.572 at baseline and 0.680 +/- 0.527 at 2 months, which suggested no significant improvement (P = 0.736, Mann-Whitney U test) during the procedure. All patients experienced improved vitreous opacity and diminished area of the lesion under funduscopy after 4 injections of IVG. No severe complications developed.
Multiple IVG seemed to be beneficial for patients with CMV retinitis after stem-cell transplantation, in reducing CMV levels in aqueous humor. Further study to optimize the dose of ganciclovir is needed in order to achieve better treatment outcomes.
|项目编号||2011CB510200 ; 30901639 ; 90561 ; 2009B04|
|资助机构||National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; EFSD/CDS/Lilly grant ; Beijing Novel Program|
|作者单位||Peking Univ, Dept Ophthalmol, Peoples Hosp, Key Lab Vis Loss & Restorat,Minist Educ, Beijing 100044, Peoples R China|
|Miao, Heng,Tao, Yong,Jiang, Yan-rong,et al. Multiple intravitreal injections of ganciclovir for cytomegalovirus retinitis after stem-cell transplantation[J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2013,251(7):1829-1833.|
|APA||Miao, Heng,Tao, Yong,Jiang, Yan-rong,&Li, Xiao-xin.(2013).Multiple intravitreal injections of ganciclovir for cytomegalovirus retinitis after stem-cell transplantation.GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,251(7),1829-1833.|
|MLA||Miao, Heng,et al."Multiple intravitreal injections of ganciclovir for cytomegalovirus retinitis after stem-cell transplantation".GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 251.7(2013):1829-1833.|