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学科主题: 临床医学
题名:
Multiple intravitreal injections of ganciclovir for cytomegalovirus retinitis after stem-cell transplantation
作者: Miao, Heng; Tao, Yong; Jiang, Yan-rong; Li, Xiao-xin
关键词: Ganciclovir ; Intravitreal injection ; Cytomegalovirus retinitis ; Transplant
刊名: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
发表日期: 2013-07-01
DOI: 10.1007/s00417-013-2368-6
卷: 251, 期:7, 页:1829-1833
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: DISEASE ; AIDS
英文摘要:

Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in patients after hematopoietic stem cell transplantation (HSCT). Although much effort has been put into dealing with CMV retinitis secondary to acquired immunodeficiency syndrome (AIDS), the few reports which have been published have mainly focused on treatment of CMVR after HSCT.

This clinical interventional retrospective study included 14 patients (eight men; mean age 23.89 +/- 12.09; 23 eyes) who suffered from CMV retinitis after stem-cell transplantation, in order to evaluate the efficacy and safety of multiple intravitreal injections of ganciclovir (IVG) for patients with CMV retinitis. All patients received 4 injections of IVG of 1 mg at 1 week intervals, and were followed up weekly for at least 2 months with measurement of best-corrected visual acuity (BCVA) and CMV levels in anterior aqueous humor with real-time polymerase chain reaction. Anterior aqueous humor was obtained before each injection.

The levels of CMV in anterior aqueous humor showed significant decrease from (6.34 +/- 15.78) x 10(5) copies/ml at baseline to (5.22 +/- 12.15) x 10(3) copies/ml at 1 month (P < 0.001, Mann-Whitney U test). CMV couldn′t be detected in 11 eyes (47.8 %) after two injections, and this rose to 18 eyes (78.3 %) at 1 month. The mean logMAR BCVA was 0.659 +/- 0.572 at baseline and 0.680 +/- 0.527 at 2 months, which suggested no significant improvement (P = 0.736, Mann-Whitney U test) during the procedure. All patients experienced improved vitreous opacity and diminished area of the lesion under funduscopy after 4 injections of IVG. No severe complications developed.

Multiple IVG seemed to be beneficial for patients with CMV retinitis after stem-cell transplantation, in reducing CMV levels in aqueous humor. Further study to optimize the dose of ganciclovir is needed in order to achieve better treatment outcomes.

语种: 英语
所属项目编号: 2011CB510200 ; 30901639 ; 90561 ; 2009B04
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; EFSD/CDS/Lilly grant ; Beijing Novel Program
WOS记录号: WOS:000320386700025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53124
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: Peking Univ, Dept Ophthalmol, Peoples Hosp, Key Lab Vis Loss & Restorat,Minist Educ, Beijing 100044, Peoples R China

Recommended Citation:
Miao, Heng,Tao, Yong,Jiang, Yan-rong,et al. Multiple intravitreal injections of ganciclovir for cytomegalovirus retinitis after stem-cell transplantation[J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,2013,251(7):1829-1833.
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