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学科主题: 基础医学
题名:
GPR56 is highly expressed in neural stem cells but downregulated during differentiation
作者: Bai, Yun2; Du, Liying1; Shen, Li2; Zhang, Ye2; Zhang, Lijun1
关键词: differentiation ; G-protein-coupled receptor 56 ; nestin ; neural progenitor cell ; neural stem cell
刊名: NEUROREPORT
发表日期: 2009-07-01
DOI: 10.1097/WNR.0b013e32832c92d7
卷: 20, 期:10, 页:918-922
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PROTEIN-COUPLED RECEPTOR ; GPCR
英文摘要:

The G-protein-coupled receptor 56 (GPR56) plays important roles in brain development and tumorigenesis. cDNA data suggest that GPR56 has potential to become a neural stem cell (NSC) or neural progenitor cell (NPC) marker. However, expression of GPR56 protein in human NSC/NPCs was not explored. Using specific antibodies and immunochemistry, we showed that GPR56 was highly expressed in nestin-positive NSC/NPCs in the ventricular/ subventricular zone of human and mouse fetal brains, and in cultured neurospheres derived from both human and mouse fetal brains. Downregulation of GPR56 protein occurred earlier than that of nestin in differentiating neurosphere cultures. Loss of GPR56 protein was also evident in well-differentiated glial fibrillary acidic protein-positive astrocytes and beta III-tubulin-positive neurons. Our data suggest that GPR56 can be used as an NSC/NPC marker within the neural cell lineage, especially in combination with nestin. NeuroReport 20:918-922 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 30270662 ; 30600167
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000267633600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53127
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100871, Peoples R China

Recommended Citation:
Bai, Yun,Du, Liying,Shen, Li,et al. GPR56 is highly expressed in neural stem cells but downregulated during differentiation[J]. NEUROREPORT,2009,20(10):918-922.
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