IR@PKUHSC  > 北京大学基础医学院  > 细胞生物学系
学科主题基础医学
GPR56 is highly expressed in neural stem cells but downregulated during differentiation
Bai, Yun2; Du, Liying1; Shen, Li2; Zhang, Ye2; Zhang, Lijun1
关键词Differentiation G-protein-coupled Receptor 56 Nestin Neural Progenitor Cell Neural Stem Cell
刊名NEUROREPORT
2009-07-01
DOI10.1097/WNR.0b013e32832c92d7
20期:10页:918-922
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]PROTEIN-COUPLED RECEPTOR ; GPCR
英文摘要

The G-protein-coupled receptor 56 (GPR56) plays important roles in brain development and tumorigenesis. cDNA data suggest that GPR56 has potential to become a neural stem cell (NSC) or neural progenitor cell (NPC) marker. However, expression of GPR56 protein in human NSC/NPCs was not explored. Using specific antibodies and immunochemistry, we showed that GPR56 was highly expressed in nestin-positive NSC/NPCs in the ventricular/ subventricular zone of human and mouse fetal brains, and in cultured neurospheres derived from both human and mouse fetal brains. Downregulation of GPR56 protein occurred earlier than that of nestin in differentiating neurosphere cultures. Loss of GPR56 protein was also evident in well-differentiated glial fibrillary acidic protein-positive astrocytes and beta III-tubulin-positive neurons. Our data suggest that GPR56 can be used as an NSC/NPC marker within the neural cell lineage, especially in combination with nestin. NeuroReport 20:918-922 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000267633600005
项目编号30270662 ; 30600167
资助机构National Natural Science Foundation of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53127
专题北京大学基础医学院_细胞生物学系
北京大学基础医学院
作者单位1.Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Bai, Yun,Du, Liying,Shen, Li,et al. GPR56 is highly expressed in neural stem cells but downregulated during differentiation[J]. NEUROREPORT,2009,20(10):918-922.
APA Bai, Yun,Du, Liying,Shen, Li,Zhang, Ye,&Zhang, Lijun.(2009).GPR56 is highly expressed in neural stem cells but downregulated during differentiation.NEUROREPORT,20(10),918-922.
MLA Bai, Yun,et al."GPR56 is highly expressed in neural stem cells but downregulated during differentiation".NEUROREPORT 20.10(2009):918-922.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Bai, Yun]的文章
[Du, Liying]的文章
[Shen, Li]的文章
百度学术
百度学术中相似的文章
[Bai, Yun]的文章
[Du, Liying]的文章
[Shen, Li]的文章
必应学术
必应学术中相似的文章
[Bai, Yun]的文章
[Du, Liying]的文章
[Shen, Li]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。