IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development
Sun, Zhuo1,2; Huang, Chuanxin2; He, Jinxue2; Lamb, Kristy L.2; Kang, Xi1,2; Gu, Tingting2; Shen, Wen Hong2; Yin, Yuxin1,2
刊名CELL REPORTS
2014-03-01
DOI10.1016/j.celrep.2014.01.030
6期:5页:844-854
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]EPITHELIAL-MESENCHYMAL TRANSITION ; COMMON FRAGILE SITES ; COWDEN-SYNDROME ; SUPPRESSOR GENE ; CANCER ; MICE ; MUTATIONS ; BREAST ; FHIT ; ACTIVATION
英文摘要

Tumor suppressor PTEN controls genomic stability and inhibits tumorigenesis. The N-terminal phosphatase domain of PTEN antagonizes the PI3K/AKT pathway, but its C-terminal function is less defined. Here, we describe a knockin mouse model of a nonsense mutation that results in the deletion of the entire Pten C-terminal region, referred to as Pten DC. Mice heterozygous for Pten DC develop multiple spontaneous tumors, including cancers and B cell lymphoma. Heterozygous deletion of the Pten C-terminal domain also causes genomic instability and common fragile site rearrangement. We found that Pten C-terminal disruption induces p53 and its downstream targets. Simultaneous depletion of p53 promotes metastasis without influencing the initiation of tumors, suggesting that p53 mainly suppresses tumor progression. Our data highlight the essential role of the PTEN C terminus in the maintenance of genomic stability and suppression of tumorigenesis.

语种英语
WOS记录号WOS:000333037800009
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53128
专题北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Inst Syst Biomed,Dept Pathol, Beijing 100191, Peoples R China
2.Cornell Univ, Weill Med Coll, Dept Radiat Oncol, New York, NY 10065 USA
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GB/T 7714
Sun, Zhuo,Huang, Chuanxin,He, Jinxue,et al. PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development[J]. CELL REPORTS,2014,6(5):844-854.
APA Sun, Zhuo.,Huang, Chuanxin.,He, Jinxue.,Lamb, Kristy L..,Kang, Xi.,...&Yin, Yuxin.(2014).PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development.CELL REPORTS,6(5),844-854.
MLA Sun, Zhuo,et al."PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development".CELL REPORTS 6.5(2014):844-854.
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