IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心
学科主题临床医学
Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
Zhi, Xu1,2; Lamperska, Katarzyna3; Golusinski, Pawel4,6; Schork, Nicholas J.5; Luczewski, Lukasz6; Kolenda, Tomasz3,7; Golusinski, Wojciech6; Masternak, Michal M.2,6
关键词Pcr Array Cancer Pathway Gene Expression Oral Cancer
刊名ONCOTARGET
2015
6期:1页:547-555
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
资助者National Institute on Aging of the National Institutes of Health ; Polish National Science Centre ; NIH ; National Institute on Aging of the National Institutes of Health ; Polish National Science Centre ; NIH
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]CANCER ; INDUCTION ; PROGNOSIS ; MICE
英文摘要

The squamous cell carcinomas represent about 90 % of all head and neck cancers, ranking the sixth most common human cancer. Approximately 450,000 of new cases of head and neck squamous cell carcinoma (HNSCC) are diagnosed every year. Unfortunately, because of diagnosis at the advanced stages and early metastasis to the lymph nodes, the HNSCC is associated with very high death rate. Identification of signature biomarkers and molecularly targeted therapies could provide more effective and specific cancer treatment, prevent recurrence, and increase survival rate. We used paired tumor and adjacent normal tissue samples to screen with RT2 Profiler (TM) PCR Array Human Cancer PathwayFinder (TM). Total of 20 up-regulated genes and two down-regulated genes were screened out. Out of 22 genes, 12 genes were subsequently validated to be significantly altered in the HNSCC; the samples were from all 41 patients. Five year survival and recurrence selected genes that could represent the biomarkers of survival and recurrence of the disease. We believe that comprehensive understanding of the unique genetic characteristics of HNSCC could provide novel diagnostic biomarkers and meet the requirement for molecular-targeted therapy for the HNSCC.

语种英语
所属项目编号R01AG032290 ; N N403 186934 ; 5 UL1 RR025774
资助者National Institute on Aging of the National Institutes of Health ; Polish National Science Centre ; NIH ; National Institute on Aging of the National Institutes of Health ; Polish National Science Centre ; NIH
WOS记录号WOS:000352065200043
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53129
Collection北京大学第三临床医学院_生殖医学中心
作者单位1.Poznan Univ Med Sci, Dept Enviromental Biol, Poznan, Poland
2.J Craig Venter Inst, Human Biol, La Jolla, CA USA
3.Med Univ Warsaw, Postgrad Sch Mol Med, Warsaw, Poland
4.Greater Poland Canc Ctr, Deptartment Canc Genet, Poznan, Poland
5.Peking Univ Third Hosp, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing, Peoples R China
6.Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32816 USA
7.Poznan Univ Med Sci, Dept Head & Neck Surg, Greater Poland Canc Ctr, Poznan, Poland
Recommended Citation
GB/T 7714
Zhi, Xu,Lamperska, Katarzyna,Golusinski, Pawel,et al. Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence[J]. ONCOTARGET,2015,6(1):547-555.
APA Zhi, Xu.,Lamperska, Katarzyna.,Golusinski, Pawel.,Schork, Nicholas J..,Luczewski, Lukasz.,...&Masternak, Michal M..(2015).Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence.ONCOTARGET,6(1),547-555.
MLA Zhi, Xu,et al."Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence".ONCOTARGET 6.1(2015):547-555.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Zhi, Xu]'s Articles
[Lamperska, Katarzyna]'s Articles
[Golusinski, Pawel]'s Articles
百度学术
百度学术Similar articles in
[Zhi, Xu]'s Articles
[Lamperska, Katarzyna]'s Articles
[Golusinski, Pawel]'s Articles
必应学术
必应学术Similar articles in
[Zhi, Xu]'s Articles
[Lamperska, Katarzyna]'s Articles
[Golusinski, Pawel]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.