IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心
学科主题临床医学
Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence
Zhi, Xu1,2; Lamperska, Katarzyna3; Golusinski, Pawel4,6; Schork, Nicholas J.5; Luczewski, Lukasz6; Kolenda, Tomasz3,7; Golusinski, Wojciech6; Masternak, Michal M.2,6
关键词Pcr Array Cancer Pathway Gene Expression Oral Cancer
刊名ONCOTARGET
2015
6期:1页:547-555
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Cell Biology
研究领域[WOS]Oncology ; Cell Biology
关键词[WOS]CANCER ; INDUCTION ; PROGNOSIS ; MICE
英文摘要

The squamous cell carcinomas represent about 90 % of all head and neck cancers, ranking the sixth most common human cancer. Approximately 450,000 of new cases of head and neck squamous cell carcinoma (HNSCC) are diagnosed every year. Unfortunately, because of diagnosis at the advanced stages and early metastasis to the lymph nodes, the HNSCC is associated with very high death rate. Identification of signature biomarkers and molecularly targeted therapies could provide more effective and specific cancer treatment, prevent recurrence, and increase survival rate. We used paired tumor and adjacent normal tissue samples to screen with RT2 Profiler (TM) PCR Array Human Cancer PathwayFinder (TM). Total of 20 up-regulated genes and two down-regulated genes were screened out. Out of 22 genes, 12 genes were subsequently validated to be significantly altered in the HNSCC; the samples were from all 41 patients. Five year survival and recurrence selected genes that could represent the biomarkers of survival and recurrence of the disease. We believe that comprehensive understanding of the unique genetic characteristics of HNSCC could provide novel diagnostic biomarkers and meet the requirement for molecular-targeted therapy for the HNSCC.

语种英语
WOS记录号WOS:000352065200043
项目编号R01AG032290 ; N N403 186934 ; 5 UL1 RR025774
资助机构National Institute on Aging of the National Institutes of Health ; Polish National Science Centre ; NIH
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53129
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Poznan Univ Med Sci, Dept Enviromental Biol, Poznan, Poland
2.J Craig Venter Inst, Human Biol, La Jolla, CA USA
3.Med Univ Warsaw, Postgrad Sch Mol Med, Warsaw, Poland
4.Greater Poland Canc Ctr, Deptartment Canc Genet, Poznan, Poland
5.Peking Univ Third Hosp, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing, Peoples R China
6.Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32816 USA
7.Poznan Univ Med Sci, Dept Head & Neck Surg, Greater Poland Canc Ctr, Poznan, Poland
推荐引用方式
GB/T 7714
Zhi, Xu,Lamperska, Katarzyna,Golusinski, Pawel,et al. Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence[J]. ONCOTARGET,2015,6(1):547-555.
APA Zhi, Xu.,Lamperska, Katarzyna.,Golusinski, Pawel.,Schork, Nicholas J..,Luczewski, Lukasz.,...&Masternak, Michal M..(2015).Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence.ONCOTARGET,6(1),547-555.
MLA Zhi, Xu,et al."Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence".ONCOTARGET 6.1(2015):547-555.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhi, Xu]的文章
[Lamperska, Katarzyna]的文章
[Golusinski, Pawel]的文章
百度学术
百度学术中相似的文章
[Zhi, Xu]的文章
[Lamperska, Katarzyna]的文章
[Golusinski, Pawel]的文章
必应学术
必应学术中相似的文章
[Zhi, Xu]的文章
[Lamperska, Katarzyna]的文章
[Golusinski, Pawel]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。