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学科主题: 临床医学
题名:
Tranexamic Acid Reduces Blood Loss After Off-Pump Coronary Surgery: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study
作者: Wang, Guyan1,2; Xie, Gaoqiang3; Jiang, Tingting1; Wang, Yuefu1,2; Wang, Weipeng1,2; Ji, Hongwen1,2; Liu, Mingzheng1,2; Chen, Lei1,2; Li, Lihuan1,2
刊名: ANESTHESIA AND ANALGESIA
发表日期: 2012-08-01
DOI: 10.1213/ANE.01301123182264a11
卷: 115, 期:2, 页:239-243
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anesthesiology
研究领域[WOS]: Anesthesiology
关键词[WOS]: ARTERY-BYPASS ; CARDIAC-SURGERY ; ON-PUMP ; METAANALYSIS ; APROTININ ; OUTCOMES ; TRANSFUSION ; MORBIDITY ; MORTALITY
英文摘要:

BACKGROUND: Bleeding and the need for allogeneic transfusions are still problems after off-pump coronary artery bypass grafting (OPCAB) surgery. We therefore evaluated the effects of an antifibrinolytic, tranexamic acid, on postoperative bleeding and transfusion requirements in patients undergoing OPCAB surgery.

METHODS: Two hundred thirty-one consecutive patients scheduled for elective OPCAB were enrolled in the study. Using a double-blind method, the patients were randomly assigned to receive either tranexamic acid (bolus 1 g before surgical incision followed by an infusion of 400 mg/h during surgery; n = 116) or a placebo (infusion equivalent volume of saline solution; n = 115). The primary outcome was 24-hour postoperative chest tube drainage. Allogeneic transfusion, mortality, major morbidities, and resource utilization were also recorded.

RESULTS: In comparison with the placebo group, the patients receiving tranexamic acid had a significant reduction in chest tube drainage at 6 hours (270 118 mL vs 416 179 mL, P < 0.001) and 24 hours (654 +/- 224 mL vs 891 +/- 295 mL, P<0.001). There was also a significant reduction in allogeneic red blood cell transfusions (47% vs 31.9%, P = 0.019) and fresh frozen plasma (29.6% vs 17.2%, P = 0.027) transfusions. There were no differences in mortality, morbidity, and resource utilization between the 2 groups.

CONCLUSIONS: Tranexamic acid reduces postoperative chest tube drainage and the requirement for allogeneic transfusion in off-pump coronary surgery. (Anesth Analg 2012;115:239-43)

语种: 英语
WOS记录号: WOS:000306769500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53130
Appears in Collections:北京大学临床研究所_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Peking Union Med Coll, Fuwai Hosp, Dept Anesthesiol, Beijing 100037, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Cardiovasc Inst, Beijing 100037, Peoples R China
3.Peking Univ, Clin Res Inst, Dept Data Management, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Guyan,Xie, Gaoqiang,Jiang, Tingting,et al. Tranexamic Acid Reduces Blood Loss After Off-Pump Coronary Surgery: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study[J]. ANESTHESIA AND ANALGESIA,2012,115(2):239-243.
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