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Plasma levels of copeptin in patients with coronary heart disease
Chai, San Bao1; Hui, Yong Ming1; Li, Xue Min2; Xiao, Yang3; Tang, Chao Shu3
关键词Coronary Heart Disease Arginine Vasopressin Copeptin Percutaneous Transluminal Coronary Angioplasty
刊名HEART AND VESSELS
2009-03-01
DOI10.1007/s00380-008-1086-1
24期:2页:79-83
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ACUTE MYOCARDIAL-INFARCTION ; ARGININE-VASOPRESSIN ; STABLE PEPTIDE ; ANTIDIURETIC-HORMONE ; SEPTIC SHOCK ; PRECURSOR ; FAILURE ; GLYCOPEPTIDE ; ACTIVATION ; INSULIN
英文摘要

The present study was undertaken to investigate alteration in plasma levels of copeptin, a stable fragment derived from provasopressin, in patients with coronary heart disease. We measured plasma level of copeptin in 21 patients with coronary heart disease (CHD) and 12 agematched healthy subjects by radioimmunoassay (RIA). Chi-square test, Student′s t-test and one-way analysis of variance were used for statistical analyses. Correlations between variables were tested by simple linear regression analysis. The plasma level of copeptin was significantly increased in patients (43.07 +/- 17.08 vs 11.13 +/- 5.73 pmol/l in controls, P < 0.01) and was further increased, by 60%, to 68.71 +/- 16.81 pmol/l on day 1 after therapy with percutaneous transluminal coronary angioplasty (PTCA) and stent (P < 0.05). On days 3 and 7 after therapy, the levels were greatly decreased, to 38.82 +/- 19.00 and 32.10 +/- 14.00 pmol/l, respectively, from that before therapy (all P < 0.05) but were higher, by 249% and 188%, respectively, than that of controls (all P < 0.01). The results suggest that the vasopressin system is activated in patients with CHD as indicated by changes in copeptin level, especially after PTCA and stent therapy. As a potential risk factor for CHD, plasma copeptin activation might have important clinical significance in terms of early intervention in patients with CHD.

语种英语
WOS记录号WOS:000264836000002
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53133
专题北京大学第三临床医学院_眼科
北京大学第一临床医学院_中心实验室
作者单位1.Beijing Fengtai Hosp, Dept Cardiovasc Dis, Beijing 100071, Peoples R China
2.Beijing Univ, Ctr Eye, Dept Ophthalmol, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
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GB/T 7714
Chai, San Bao,Hui, Yong Ming,Li, Xue Min,et al. Plasma levels of copeptin in patients with coronary heart disease[J]. HEART AND VESSELS,2009,24(2):79-83.
APA Chai, San Bao,Hui, Yong Ming,Li, Xue Min,Xiao, Yang,&Tang, Chao Shu.(2009).Plasma levels of copeptin in patients with coronary heart disease.HEART AND VESSELS,24(2),79-83.
MLA Chai, San Bao,et al."Plasma levels of copeptin in patients with coronary heart disease".HEART AND VESSELS 24.2(2009):79-83.
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