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Neamine-heterocycle conjugates as potential anti-HIV agents
Yan, Ri-Bai1; Wu, Yan-Fen1; Liu, Jun2; Zhang, Xiao-Lian2; Ye, Xin-Shan1
关键词Aminoglycoside Anti-hiv Neamine Synthesis
刊名CHINESE CHEMICAL LETTERS
2013-04-01
DOI10.1016/j.cclet.2013.03.009
24期:4页:273-278
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]DIMERIZATION INITIATION SITE ; RESISTANT BACTERIAL STRAINS ; REV RESPONSIVE ELEMENT ; AMINOGLYCOSIDE ANTIBIOTICS ; RNA-BINDING ; TARGETING RNA ; TAR RNA ; DERIVATIVES ; INHIBITORS ; CONDENSATION
英文摘要

A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents. (C) 2013 Xiao-Lian Zhang, Xin-Shan Ye. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种英语
WOS记录号WOS:000319307900003
项目编号2012ZX09502001-001 ; 2012CB822100 ; 2012CB720604 ; 81025008 ; 30921001
资助机构Ministry of Science and Technology of China ; National Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53135
专题北京大学药学院
北京大学药学院_药物化学系
通讯作者Zhang, Xiao-Lian
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Wuhan Univ, Sch Med, Hubei Prov Key Lab Allergy & Immunol, State Key Lab Virol,Dept Immunol, Wuhan 430071, Peoples R China
推荐引用方式
GB/T 7714
Yan, Ri-Bai,Wu, Yan-Fen,Liu, Jun,et al. Neamine-heterocycle conjugates as potential anti-HIV agents[J]. CHINESE CHEMICAL LETTERS,2013,24(4):273-278.
APA Yan, Ri-Bai,Wu, Yan-Fen,Liu, Jun,Zhang, Xiao-Lian,&Ye, Xin-Shan.(2013).Neamine-heterocycle conjugates as potential anti-HIV agents.CHINESE CHEMICAL LETTERS,24(4),273-278.
MLA Yan, Ri-Bai,et al."Neamine-heterocycle conjugates as potential anti-HIV agents".CHINESE CHEMICAL LETTERS 24.4(2013):273-278.
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