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学科主题: 药学
题名:
Neamine-heterocycle conjugates as potential anti-HIV agents
作者: Yan, Ri-Bai1; Wu, Yan-Fen1; Liu, Jun2; Zhang, Xiao-Lian2; Ye, Xin-Shan1
关键词: Aminoglycoside ; Anti-HIV ; Neamine ; Synthesis
刊名: CHINESE CHEMICAL LETTERS
发表日期: 2013-04-01
DOI: 10.1016/j.cclet.2013.03.009
卷: 24, 期:4, 页:273-278
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: DIMERIZATION INITIATION SITE ; RESISTANT BACTERIAL STRAINS ; REV RESPONSIVE ELEMENT ; AMINOGLYCOSIDE ANTIBIOTICS ; RNA-BINDING ; TARGETING RNA ; TAR RNA ; DERIVATIVES ; INHIBITORS ; CONDENSATION
英文摘要:

A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents. (C) 2013 Xiao-Lian Zhang, Xin-Shan Ye. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种: 英语
所属项目编号: 2012ZX09502001-001 ; 2012CB822100 ; 2012CB720604 ; 81025008 ; 30921001
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China
WOS记录号: WOS:000319307900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53135
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Wuhan Univ, Sch Med, Hubei Prov Key Lab Allergy & Immunol, State Key Lab Virol,Dept Immunol, Wuhan 430071, Peoples R China

Recommended Citation:
Yan, Ri-Bai,Wu, Yan-Fen,Liu, Jun,et al. Neamine-heterocycle conjugates as potential anti-HIV agents[J]. CHINESE CHEMICAL LETTERS,2013,24(4):273-278.
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