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Chemical analysis of Eriocaulon buergerianum and adulterating species by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry
Qiao, Xue1; Ye, Guan2; Liu, Chun-Fang1; Zhang, Zhi-Xiang3; Tu, Qiang3; Dong, Jing4; Li, Yue-Qi4; Guo, De-An1; Ye, Min1
关键词Eriocaulon Buergerianum Hplc-dad-esi-ms(n) Flavonoids Naphthopyranones Chinese Herbal Medicine
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2012-01-05
DOI10.1016/j.jpba.2011.08.033
57页:133-142
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]PHENOLIC-COMPOUNDS ; FLAVONOIDS ; PATULETIN ; LIGULATUM
英文摘要

Eriocaulon buergerianum Koern. is the botanical source for the Chinese herbal medicine Gu-Jing-Cao. Other Eriocaulon species are also used as the same herb in local areas and are difficult to be differentiated. In order to improve the quality control of Gu-Jing-Cao, chemical constituents of E. buergerianum and adulterating species were analyzed by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI-MS(n)). The 70% methanol extracts were separated on a Zorbax SB-C(18) column and eluted with acetonitrile-water (each containing 0.1% formic acid). The compounds were identified by ion-trap mass spectrometry in both positive and negative ion modes. From E. buergerianum, E. faberi, E. sexangulare and E. cinereum, a total of 72 compounds were characterized, including 37 flavonols, 6 flavones, 4 isoflavones, 6 xanthones, 14 naphthopyranones, 3 phenolic acids, and 2 other flavonoids. Chemical variation of these four species were studied at three tiers, HPLC fingerprinting, quantitation of six major flavonoids, and semi-quantitative analysis of all characterized compounds, in combination with principal component analysis. E. buergerianum contained abundant flavonols and naphthopyranones, with minor flavones and xanthones; E. cinereum contained abundant isoflavones and flavones, together with few naphthopyranones: E. sexangulare was rich in flavones; and E. faberi contained abundant xanthones. Based on the above chemical analysis, E. buergerianum could be explicitly differentiated from the adulterating species, and the botanical species of 13 commercial batches of Gu-Jing-Cao were identified correctly. This is the first report on comprehensive chemical analysis of Eriocaulon species. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000297539500020
项目编号985-2-119-121
资助机构Peking University Health Science Center
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53136
专题北京大学药学院
作者单位1.Shanghai Pharmaceut Grp, Cent Res Inst, Shanghai 201203, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Beijing 100083, Peoples R China
4.Shimadzu Int Trading Shanghai Co Ltd, Beijing Off, Beijing 100020, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Xue,Ye, Guan,Liu, Chun-Fang,et al. Chemical analysis of Eriocaulon buergerianum and adulterating species by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2012,57:133-142.
APA Qiao, Xue.,Ye, Guan.,Liu, Chun-Fang.,Zhang, Zhi-Xiang.,Tu, Qiang.,...&Ye, Min.(2012).Chemical analysis of Eriocaulon buergerianum and adulterating species by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,57,133-142.
MLA Qiao, Xue,et al."Chemical analysis of Eriocaulon buergerianum and adulterating species by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 57(2012):133-142.
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