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学科主题: 精神卫生
题名:
A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population
作者: Yue, Weihua1,2; Yang, Yongfeng3,4; Zhang, Yanling1,2; Lu, Tianlan1,2; Hu, Xiaofeng1,2; Wang, Lifang1,2; Ruan, Yanyan1,2; Lv, Luxian3,4; Zhang, Dai1,2
关键词: Schizophrenia Neurexin-1 (NRXN1) ; Haplotype ; age-at-onset
刊名: BEHAVIORAL AND BRAIN FUNCTIONS
发表日期: 2011-04-11
DOI: 10.1186/1744-9081-7-7
卷: 7
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: GENOME-WIDE ASSOCIATION ; AUTISM SPECTRUM DISORDER ; ALPHA-NEUREXINS ; STRUCTURAL VARIANTS ; NICOTINE DEPENDENCE ; VISUALIZATION ; DISRUPTION ; DELETION ; LINKAGE ; SYNAPSE
英文摘要:

Background: Recent research has implicated that mutations in the neurexin-1 (NRXN1) gene on chromosome 2p16.3 might play a role in schizophrenia, autism, and nicotine dependence. In order to explore the association of NRXN1 polymorphisms with schizophrenia, we made a case-control association study in Chinese Han population.

Methods: We examined six tag single nucleotide polymorphisms (SNPs) spanning 116.7 kb of NRXN1 in 768 schizophrenic patients and 738 healthy control subjects. The association of NRXN1 polymorphisms with schizophrenia and the age-at-onset of this disease were explored.

Results: Our results showed that four SNPs of NRXN1 gene were significantly associated with schizophrenia (rs10490168: G > A, p = 0.017; rs2024513: A > G, p = 0.006; rs13382584: T > C, p = 0.009; and rs1558852: G > A, p = 0.031). Furthermore, the association of SNP rs2024513 with schizophrenia remained significance after the Bonferroni correction. Haplotypes consisting of above six SNPs also showed significantly associated with schizophrenia (global chi-square = 14.725, p = 0.022). A protective haplotype AGTGCA remained associated with schizophrenia, even after 10,000 permutation tests (empirical p-value = 0.043). However, we did not find any association with age-at-onset of schizophrenia with NRXN1 polymorphisms.

Conclusions: Our findings suggest that NRXN1 might represent a major susceptibility gene for schizophrenia in Chinese Han population.

语种: 英语
所属项目编号: 30870896 ; 81071087 ; 2009AA022702 ; 2007CB512301 ; 2007BAI17B04
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Basic Research Program of China ; National Key Technology RD Program
WOS记录号: WOS:000289712400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53138
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Xinxiang Med Univ, Affiliated Hosp 2, Dept Psychiat, Xinxiang 453002, Peoples R China
4.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang 453002, Peoples R China

Recommended Citation:
Yue, Weihua,Yang, Yongfeng,Zhang, Yanling,et al. A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2011,7.
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