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A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population
Yue, Weihua1,2; Yang, Yongfeng3,4; Zhang, Yanling1,2; Lu, Tianlan1,2; Hu, Xiaofeng1,2; Wang, Lifang1,2; Ruan, Yanyan1,2; Lv, Luxian3,4; Zhang, Dai1,2
关键词Schizophrenia Neurexin-1 (Nrxn1) Haplotype Age-at-onset
刊名BEHAVIORAL AND BRAIN FUNCTIONS
2011-04-11
DOI10.1186/1744-9081-7-7
7
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]GENOME-WIDE ASSOCIATION ; AUTISM SPECTRUM DISORDER ; ALPHA-NEUREXINS ; STRUCTURAL VARIANTS ; NICOTINE DEPENDENCE ; VISUALIZATION ; DISRUPTION ; DELETION ; LINKAGE ; SYNAPSE
英文摘要

Background: Recent research has implicated that mutations in the neurexin-1 (NRXN1) gene on chromosome 2p16.3 might play a role in schizophrenia, autism, and nicotine dependence. In order to explore the association of NRXN1 polymorphisms with schizophrenia, we made a case-control association study in Chinese Han population.

Methods: We examined six tag single nucleotide polymorphisms (SNPs) spanning 116.7 kb of NRXN1 in 768 schizophrenic patients and 738 healthy control subjects. The association of NRXN1 polymorphisms with schizophrenia and the age-at-onset of this disease were explored.

Results: Our results showed that four SNPs of NRXN1 gene were significantly associated with schizophrenia (rs10490168: G > A, p = 0.017; rs2024513: A > G, p = 0.006; rs13382584: T > C, p = 0.009; and rs1558852: G > A, p = 0.031). Furthermore, the association of SNP rs2024513 with schizophrenia remained significance after the Bonferroni correction. Haplotypes consisting of above six SNPs also showed significantly associated with schizophrenia (global chi-square = 14.725, p = 0.022). A protective haplotype AGTGCA remained associated with schizophrenia, even after 10,000 permutation tests (empirical p-value = 0.043). However, we did not find any association with age-at-onset of schizophrenia with NRXN1 polymorphisms.

Conclusions: Our findings suggest that NRXN1 might represent a major susceptibility gene for schizophrenia in Chinese Han population.

语种英语
WOS记录号WOS:000289712400001
项目编号30870896 ; 81071087 ; 2009AA022702 ; 2007CB512301 ; 2007BAI17B04
资助机构National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; National Basic Research Program of China ; National Key Technology RD Program
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53138
专题北京大学精神卫生研究所
北京大学第一临床医学院_妇产科
北京大学口腔医学院_牙周科
北京大学精神卫生研究所_精神科
北京大学精神卫生研究所_生化室
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
3.Xinxiang Med Univ, Affiliated Hosp 2, Dept Psychiat, Xinxiang 453002, Peoples R China
4.Henan Mental Hosp, Henan Key Lab Biol Psychiat, Xinxiang 453002, Peoples R China
推荐引用方式
GB/T 7714
Yue, Weihua,Yang, Yongfeng,Zhang, Yanling,et al. A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2011,7.
APA Yue, Weihua.,Yang, Yongfeng.,Zhang, Yanling.,Lu, Tianlan.,Hu, Xiaofeng.,...&Zhang, Dai.(2011).A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population.BEHAVIORAL AND BRAIN FUNCTIONS,7.
MLA Yue, Weihua,et al."A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population".BEHAVIORAL AND BRAIN FUNCTIONS 7(2011).
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