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学科主题: 基础医学
题名:
Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression
作者: Zhang, AH1; Gao, S1; Fan, JL1; Huang, W1; Zhao, TQ1; Liu, G1
关键词: lecithin cholesterol acyltransferase ; high density ; lipoprotein ; bile acid ; adenovirils ; gene ; hamster
刊名: FEBS LETTERS
发表日期: 2004-07-16
DOI: 10.1016/j.feblet.2004.06.017
卷: 570, 期:1-3, 页:25-29
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: DENSITY-LIPOPROTEIN CHOLESTEROL ; ADENOVIRUS-MEDIATED TRANSFER ; ACYLTRANSFERASE-DEFICIENT MICE ; DIET-INDUCED ATHEROSCLEROSIS ; APOLIPOPROTEIN-A-I ; TRANSGENIC MICE ; HUMAN LECITHIN ; GENE ; RECEPTOR ; RABBITS
英文摘要:

Lecithin cholesterol acyltransferase (LCAT) is a key enzyme in the metabolism of high density lipoprotein (HDL), which has been found inversely correlated with atherosclerosis. Adenovirus mediated overexpression of human LCAT (hLCAT) in hamsters resulted in increased levels of plasma total cholesterol, HDL cholesterol, phospholipids and enlarged particle size of HDL. It also increased cholesterol and total bile acid concentrations in bile. Hepatic mRNA level of cholesterol 7alpha hydroxylase increased 2.7-fold in hamsters. However, such effects were not observed in mice in a parallel experiment. This study suggests that overexpression of hLCAT in hamsters facilitated reverse cholesterol transport. Similar metabolic changes in humans might modify atherogenic risk. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000222885400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53142
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Minist Educ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Mol Chem, Beijing 100083, Peoples R China
3.Univ Tsukuba, Inst Basic Med Sci, Dept Pathol, Cardiovasc Dis Lab, Tsukuba, Ibaraki 3058575, Japan

Recommended Citation:
Zhang, AH,Gao, S,Fan, JL,et al. Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression[J]. FEBS LETTERS,2004,570(1-3):25-29.
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