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学科主题基础医学
Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression
Zhang, AH1; Gao, S1; Fan, JL1; Huang, W1; Zhao, TQ1; Liu, G1
关键词Lecithin Cholesterol Acyltransferase High Density Lipoprotein Bile Acid Adenovirils Gene Hamster
刊名FEBS LETTERS
2004-07-16
DOI10.1016/j.feblet.2004.06.017
570期:1-3页:25-29
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]DENSITY-LIPOPROTEIN CHOLESTEROL ; ADENOVIRUS-MEDIATED TRANSFER ; ACYLTRANSFERASE-DEFICIENT MICE ; DIET-INDUCED ATHEROSCLEROSIS ; APOLIPOPROTEIN-A-I ; TRANSGENIC MICE ; HUMAN LECITHIN ; GENE ; RECEPTOR ; RABBITS
英文摘要

Lecithin cholesterol acyltransferase (LCAT) is a key enzyme in the metabolism of high density lipoprotein (HDL), which has been found inversely correlated with atherosclerosis. Adenovirus mediated overexpression of human LCAT (hLCAT) in hamsters resulted in increased levels of plasma total cholesterol, HDL cholesterol, phospholipids and enlarged particle size of HDL. It also increased cholesterol and total bile acid concentrations in bile. Hepatic mRNA level of cholesterol 7alpha hydroxylase increased 2.7-fold in hamsters. However, such effects were not observed in mice in a parallel experiment. This study suggests that overexpression of hLCAT in hamsters facilitated reverse cholesterol transport. Similar metabolic changes in humans might modify atherogenic risk. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000222885400005
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53142
专题北京大学基础医学院_心血管所
作者单位1.Peking Univ, Minist Educ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Mol Chem, Beijing 100083, Peoples R China
3.Univ Tsukuba, Inst Basic Med Sci, Dept Pathol, Cardiovasc Dis Lab, Tsukuba, Ibaraki 3058575, Japan
推荐引用方式
GB/T 7714
Zhang, AH,Gao, S,Fan, JL,et al. Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression[J]. FEBS LETTERS,2004,570(1-3):25-29.
APA Zhang, AH,Gao, S,Fan, JL,Huang, W,Zhao, TQ,&Liu, G.(2004).Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression.FEBS LETTERS,570(1-3),25-29.
MLA Zhang, AH,et al."Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression".FEBS LETTERS 570.1-3(2004):25-29.
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