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Combinations of oseltamivir and fibrates prolong the mean survival time of mice infected with the lethal H7N9 influenza virus
作者: Xu, Lili1,2; Bao, Linlin1,2; Li, Fengdi1,2; Gu, Songzhi1,2; Lv, Qi1,2; Yuan, Jing1,2; Xu, Yanfeng1,2; Zhu, Hua1,2; Deng, Wei1,2; Li, Yanhong1,2; Yao, Yanfeng1,2; Yu, Pin1,2; Gao, Zhancheng3; Qin, Chuan1,2
刊名: JOURNAL OF GENERAL VIROLOGY
发表日期: 2015
DOI: 10.1099/vir.0.069799-0
卷: 96, 页:46-51
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Virology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Virology
关键词[WOS]: PROLIFERATOR-ACTIVATED RECEPTORS ; NEURAMINIDASE INHIBITORS ; INFLAMMATION ; THERAPY ; STATINS ; MOUSE ; SIMVASTATIN ; RESISTANCE ; MODELS ; ALPHA
英文摘要:

The outbreak of human infections caused by the novel avian-origin H7N9 influenza viruses in China since March 2013 underscores the urgent need to find an effective treatment strategy against H7N9 infection in humans. In this study, we assessed the effectiveness of combinations of oseltamivir and two immunomodulators (simvastatin and fenofibrate) against H7N9 infection in a mouse model. Mice treated with oseltamivir plus fenofibrate exhibited the longest mean survival time, the largest reduction of viral titre in lung tissue, the highest levels of CD4(+) and CD8(+) T-lymphocytes, and the greatest decrease in pulmonary inflammation. Thus, the combination of oseltamivir plus fenofibrate improved the outcomes of mice infected with H7N9 virus by simultaneously reducing viral replication and normalizing the aberrant immune response. This drug combination should be considered in randomized controlled trials of treatments for H7N9 patients.

语种: 英语
所属项目编号: 2012ZX10004501-004 ; 2012ZX10004404 ; 2012ZX10004301-8 ; KJYJ-2013-01-04 ; 31370203 ; 7142106 ; 2012Y02 ; 2012D15
项目资助者: National Science and Technology Major Projects of Infectious Disease ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fundamental Research Funds for the Central Universities
WOS记录号: WOS:000355784600006
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53147
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing, Peoples R China
2.Peking Union Med Coll, Comparat Med Ctr, Key Lab Human Dis Comparat Med, Minist Hlth, Beijing 100021, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Lili,Bao, Linlin,Li, Fengdi,et al. Combinations of oseltamivir and fibrates prolong the mean survival time of mice infected with the lethal H7N9 influenza virus[J]. JOURNAL OF GENERAL VIROLOGY,2015,96:46-51.
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