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Combinations of oseltamivir and fibrates prolong the mean survival time of mice infected with the lethal H7N9 influenza virus
Xu, Lili1,2; Bao, Linlin1,2; Li, Fengdi1,2; Gu, Songzhi1,2; Lv, Qi1,2; Yuan, Jing1,2; Xu, Yanfeng1,2; Zhu, Hua1,2; Deng, Wei1,2; Li, Yanhong1,2; Yao, Yanfeng1,2; Yu, Pin1,2; Gao, Zhancheng3; Qin, Chuan1,2
刊名JOURNAL OF GENERAL VIROLOGY
2015
DOI10.1099/vir.0.069799-0
96页:46-51
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Virology
研究领域[WOS]Biotechnology & Applied Microbiology ; Virology
关键词[WOS]PROLIFERATOR-ACTIVATED RECEPTORS ; NEURAMINIDASE INHIBITORS ; INFLAMMATION ; THERAPY ; STATINS ; MOUSE ; SIMVASTATIN ; RESISTANCE ; MODELS ; ALPHA
英文摘要

The outbreak of human infections caused by the novel avian-origin H7N9 influenza viruses in China since March 2013 underscores the urgent need to find an effective treatment strategy against H7N9 infection in humans. In this study, we assessed the effectiveness of combinations of oseltamivir and two immunomodulators (simvastatin and fenofibrate) against H7N9 infection in a mouse model. Mice treated with oseltamivir plus fenofibrate exhibited the longest mean survival time, the largest reduction of viral titre in lung tissue, the highest levels of CD4(+) and CD8(+) T-lymphocytes, and the greatest decrease in pulmonary inflammation. Thus, the combination of oseltamivir plus fenofibrate improved the outcomes of mice infected with H7N9 virus by simultaneously reducing viral replication and normalizing the aberrant immune response. This drug combination should be considered in randomized controlled trials of treatments for H7N9 patients.

语种英语
WOS记录号WOS:000355784600006
项目编号2012ZX10004501-004 ; 2012ZX10004404 ; 2012ZX10004301-8 ; KJYJ-2013-01-04 ; 31370203 ; 7142106 ; 2012Y02 ; 2012D15
资助机构National Science and Technology Major Projects of Infectious Disease ; Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fundamental Research Funds for the Central Universities
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53147
专题北京大学第二临床医学院
北京大学第二临床医学院_呼吸科
作者单位1.Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing, Peoples R China
2.Peking Union Med Coll, Comparat Med Ctr, Key Lab Human Dis Comparat Med, Minist Hlth, Beijing 100021, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100871, Peoples R China
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GB/T 7714
Xu, Lili,Bao, Linlin,Li, Fengdi,et al. Combinations of oseltamivir and fibrates prolong the mean survival time of mice infected with the lethal H7N9 influenza virus[J]. JOURNAL OF GENERAL VIROLOGY,2015,96:46-51.
APA Xu, Lili.,Bao, Linlin.,Li, Fengdi.,Gu, Songzhi.,Lv, Qi.,...&Qin, Chuan.(2015).Combinations of oseltamivir and fibrates prolong the mean survival time of mice infected with the lethal H7N9 influenza virus.JOURNAL OF GENERAL VIROLOGY,96,46-51.
MLA Xu, Lili,et al."Combinations of oseltamivir and fibrates prolong the mean survival time of mice infected with the lethal H7N9 influenza virus".JOURNAL OF GENERAL VIROLOGY 96(2015):46-51.
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