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Anti-thrombotic activity of PDR, a newly synthesized L-Arg derivative, on three thrombosis models in rats
Tang, ZY; Wang, YY; Xiao, YL; Zhao, M; Peng, SQ
关键词Polyaspartoyl-l-arginine Thrombosis Platelet Aggregation Nitric Oxide
刊名THROMBOSIS RESEARCH
2003-05-01
DOI10.1016/S0049-3848(03)00339-6
110期:2-3页:127-133
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]PLATELET ACTIVATION ; NITRIC-OXIDE ; MYOCARDIAL-INFARCTION ; S-NITROSOGLUTATHIONE ; ARTERIAL THROMBOSIS ; UNSTABLE ANGINA ; AGGREGATION ; INHIBITION ; DISEASE ; MECHANISMS
英文摘要

The possibility of a newly synthesized L-arginine derivative, polyaspartoyl-L-arginine (PDR), as a novel anti-thrombotic agent and its mode of action were investigated. The anti-platelet effects of PDR in rats ex vivo, anti-thrombotic effects in three thrombosis models in rats and its effect on some autacoids (nitric oxide [NO], thromboxane [TXA(2)] and prostacyclin [PGI(2)]) were studied. PDR (i.g.) significantly inhibited ADP-, collagen- or thrombin-induced rat platelet aggregation. In arteriovenous shunt model and ferric chloride-induced arterial thrombosis model in rats, PDR (i.g.) significantly reduced the thrombus weight. In electrical stimulation-induced arterial thrombosis in rats, PDR (i.v.) dose-dependently prolonged the thrombus occlusion time (OT). PDR increased the concentration of NO in plasma. In contrast with aspirin (ASA), PDR did not influence on the TXA(2) and PGI(2) levels in plasma. In conclusion, PDR is provided with significant inhibitory effect on platelet aggregation and prevention effect on platelet related thrombosis, which is probably attributed to its inhibition on platelet function by L-arginine-NO pathway. The results demonstrate that PDR is a novel, oral and venous effective platelet aggregation inhibitor and has a possibility used as an anti-thrombotic agent. (C) 2003 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000184729400008
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53150
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Tang, ZY,Wang, YY,Xiao, YL,et al. Anti-thrombotic activity of PDR, a newly synthesized L-Arg derivative, on three thrombosis models in rats[J]. THROMBOSIS RESEARCH,2003,110(2-3):127-133.
APA Tang, ZY,Wang, YY,Xiao, YL,Zhao, M,&Peng, SQ.(2003).Anti-thrombotic activity of PDR, a newly synthesized L-Arg derivative, on three thrombosis models in rats.THROMBOSIS RESEARCH,110(2-3),127-133.
MLA Tang, ZY,et al."Anti-thrombotic activity of PDR, a newly synthesized L-Arg derivative, on three thrombosis models in rats".THROMBOSIS RESEARCH 110.2-3(2003):127-133.
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