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学科主题: 药学
题名:
Anti-thrombotic activity of PDR, a newly synthesized L-Arg derivative, on three thrombosis models in rats
作者: Tang, ZY; Wang, YY; Xiao, YL; Zhao, M; Peng, SQ
关键词: polyaspartoyl-L-arginine ; thrombosis ; platelet aggregation ; nitric oxide
刊名: THROMBOSIS RESEARCH
发表日期: 2003-05-01
DOI: 10.1016/S0049-3848(03)00339-6
卷: 110, 期:2-3, 页:127-133
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: PLATELET ACTIVATION ; NITRIC-OXIDE ; MYOCARDIAL-INFARCTION ; S-NITROSOGLUTATHIONE ; ARTERIAL THROMBOSIS ; UNSTABLE ANGINA ; AGGREGATION ; INHIBITION ; DISEASE ; MECHANISMS
英文摘要:

The possibility of a newly synthesized L-arginine derivative, polyaspartoyl-L-arginine (PDR), as a novel anti-thrombotic agent and its mode of action were investigated. The anti-platelet effects of PDR in rats ex vivo, anti-thrombotic effects in three thrombosis models in rats and its effect on some autacoids (nitric oxide [NO], thromboxane [TXA(2)] and prostacyclin [PGI(2)]) were studied. PDR (i.g.) significantly inhibited ADP-, collagen- or thrombin-induced rat platelet aggregation. In arteriovenous shunt model and ferric chloride-induced arterial thrombosis model in rats, PDR (i.g.) significantly reduced the thrombus weight. In electrical stimulation-induced arterial thrombosis in rats, PDR (i.v.) dose-dependently prolonged the thrombus occlusion time (OT). PDR increased the concentration of NO in plasma. In contrast with aspirin (ASA), PDR did not influence on the TXA(2) and PGI(2) levels in plasma. In conclusion, PDR is provided with significant inhibitory effect on platelet aggregation and prevention effect on platelet related thrombosis, which is probably attributed to its inhibition on platelet function by L-arginine-NO pathway. The results demonstrate that PDR is a novel, oral and venous effective platelet aggregation inhibitor and has a possibility used as an anti-thrombotic agent. (C) 2003 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000184729400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53150
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Tang, ZY,Wang, YY,Xiao, YL,et al. Anti-thrombotic activity of PDR, a newly synthesized L-Arg derivative, on three thrombosis models in rats[J]. THROMBOSIS RESEARCH,2003,110(2-3):127-133.
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