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学科主题: 临床医学
题名:
Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice
作者: Stout, Michael B.1; Swindell, William R.2; Zhi, Xu3,4; Rohde, Kyle4; List, Edward O.5,6; Berryman, Darlene E.5,6; Kopchick, John J.5,6; Gesing, Adam7; Fang, Yimin8; Masternak, Michal M.4,9
关键词: brown adipose tissue ; growth hormone ; inflammation ; metabolism ; white adipose tissue ; Gerotarget section
刊名: ONCOTARGET
发表日期: 2015-09-29
DOI: 10.18632/oncotarget.5760
卷: 6, 期:29, 页:26702-26715
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: INDUCED INSULIN-RESISTANCE ; RECEPTOR KNOCKOUT MICE ; GROWTH-HORMONE ; GENE-EXPRESSION ; CALORIC RESTRICTION ; CELLULAR SENESCENCE ; DWARF MICE ; NULL MICE ; LIFE-SPAN ; INFLAMMATION
英文摘要:

Mice lacking the growth hormone receptor (GHRKO) exhibit improved lifespan and healthspan due to loss of growth hormone signaling. Both the distribution and activity of brown and white adipose tissue (BAT and WAT) are altered in GHRKO mice, but the contribution of each tissue to age-related phenotypes has remained unclear. We therefore used whole-genome microarrays to evaluate transcriptional differences in BAT and WAT depots between GHRKO and normal littermates at six months of age. Our findings reveal a unique BAT transcriptome as well as distinctive responses of BAT to Ghr ablation. BAT from GHRKO mice exhibited elevated expression of genes associated with mitochondria and metabolism, along with reduced expression of genes expressed by monocyte-derived cells (dendritic cells [ DC] and macrophages). Largely the opposite was observed in WAT, with increased expression of DC-expressed genes and reduced expression of genes associated with metabolism, cellular respiration and the mitochondrial inner envelope. These findings demonstrate divergent response patterns of BAT and WAT to loss of GH signaling in GHRKO mice. These patterns suggest both BAT and WAT contribute in different ways to phenotypes in GHRKO mice, with Ghr ablation blunting inflammation in BAT as well as cellular metabolism and mitochondrial biogenesis in WAT.

语种: 英语
所属项目编号: AG032290 ; AG031736 ; 81401201 ; 7152154 ; DEC-2012/04/M/NZ4/00198 ; 507/1- 107- 05/507-10050
项目资助者: National Institutes of Health ; Robert and Arlene Kogod Career Development Award in Aging Research - American Skin Association Carson Family Research Scholar Award in Psoriasis ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Polish National Science Centre of the Medical University of Lodz, Poland
WOS记录号: WOS:000363161300021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53152
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Mayo Clin, Robert & Arlene Kogod Ctr Aging, Rochester, MN USA
2.Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA
3.Peking Univ, Ctr Reprod Med, Dept Obstet & Gynecol, Hosp 3, Beijing 100871, Peoples R China
4.Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32816 USA
5.Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 USA
6.Ohio Univ, Heritage Coll Osteopath Med, Athens, OH 45701 USA
7.Med Univ Lodz, Dept Oncol Endocrinol, Lodz, Poland
8.So Illinois Univ, Sch Med, Dept Internal Med, Geriatr Res Lab, Springfield, IL USA
9.Greater Poland Canc Ctr, Dept Head & Neck Surg, Poznan, Poland

Recommended Citation:
Stout, Michael B.,Swindell, William R.,Zhi, Xu,et al. Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice[J]. ONCOTARGET,2015,6(29):26702-26715.
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