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学科主题: 临床医学
题名:
Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review
作者: Yin, Wei-Hua1; Li, Jian1; Chan, John K. C.2
关键词: Haemangioblastoma ; Kidney ; CD10 ; Rhabdoid features
刊名: DIAGNOSTIC PATHOLOGY
发表日期: 2012-04-12
DOI: 10.1186/1746-1596-7-39
卷: 7
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: RENAL-CELL CARCINOMA ; LINDAU-DISEASE ; ADULT ; TUMOR
英文摘要:

We present here an intriguing case of sporadic renal haemangioblastoma occurring in a 61-year-old male. The tumor consisted of nests of polygonal cells and abundant capillary networks. The neoplastic cells generally showed abundant eosinophilic cytoplasm and prominent eccentric nuclei, resembling the rhabdoid cells. Pronounced intranuclear cytoplasmic pseudoinclusions were another significant feature seen. NSE, a-inhibin and S100 were positive in tumor cells and particularly, focal CD10 expressions were observed. This is possibly the first reported case of a haemangioblastoma showing a rhabdoid phenotype and CD10 immunopositivity. Malignant rhabdoid tumor and renal cell carcinoma with rhabdoid features were probably the most challenging mimics need to be differentiated. The result of focal CD10 staining in our case may further lead to confusion with renal cell carcinoma. To avoid misdiagnosis, more considerations should be attached to the rare neoplasm.

Virtual Slides: The virtual slide(s) for this article can be found here: http://www. diagnosticpathology. diagnomx. eu/vs/1068858553657049

语种: 英语
WOS记录号: WOS:000304678100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53153
Appears in Collections:北京大学深圳医院_病理科_期刊论文

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作者单位: 1.Peking Univ, Dept Pathol, Shenzhen Hosp, Shenzhen 518000, Peoples R China
2.Queen Elizabeth Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Yin, Wei-Hua,Li, Jian,Chan, John K. C.. Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review[J]. DIAGNOSTIC PATHOLOGY,2012,7.
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