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学科主题: 药学
题名:
Optimizing the quadruple-potential waveform for the pulsed amperometric detection of neomycin
作者: Ding, YS1; Yu, H1; Mou, SF1
关键词: detection, LC ; waveforms ; pulsed amperometric detection ; neomycin ; antibiotics ; aminoglycosides ; glycosidcs
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2004-06-11
DOI: 10.1016/j.chroma.2003.12.051
卷: 1039, 期:1-2, 页:39-43
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; PRE-CAPILLARY DERIVATIZATION ; ELECTROCHEMICAL DETECTION ; UV DETECTION ; SULFATE ; TOBRAMYCIN
英文摘要:

Determination of neomycin is important for quality control of the pharmaceutical preparation. A quadruple-potential waveform used for pulsed amperometric detection of neomycin was investigated. The waveform cleans the electrode by application of a potential more negative than the potential limit to avoid the formation of gold oxide during applying positive potential to clean gold electrode, thus decreasing the dissolution resulting recession of the gold working electrode within gold oxide formation/reduction cycles in the triple-potential waveform. Waveform parameters were optimized to maximize the signal-to-noise ratio (S/N). The detection limit of neomycin B is lower than 0.01 mug/ml. The linearity of framycetin (plotted as peak area of neomycin B) ranges from 0.05 to 100 mug/ml with correlation coefficient 0.9998. R.S.D. (it = 60) of the peak area of neomycin B is lower than 2%. The quadruple-potential waveform shows low detection limits and long-term reproducibility. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000221769000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53155
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

Recommended Citation:
Ding, YS,Yu, H,Mou, SF. Optimizing the quadruple-potential waveform for the pulsed amperometric detection of neomycin[J]. JOURNAL OF CHROMATOGRAPHY A,2004,1039(1-2):39-43.
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