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Optimizing the quadruple-potential waveform for the pulsed amperometric detection of neomycin
Ding, YS()1; Yu, H()1; Mou, SF()1
关键词Waveforms Detection Pulsed Amperometric Detection Lc Neomycin Antibiotics Aminoglycosides Glycosidcs
刊名JOURNAL OF CHROMATOGRAPHY A
2004-06-11
DOI10.1016/j.chroma.2003.12.051
1039期:1-2页:39-43
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]PERFORMANCE LIQUID-CHROMATOGRAPHY ; PRE-CAPILLARY DERIVATIZATION ; ELECTROCHEMICAL DETECTION ; UV DETECTION ; SULFATE ; TOBRAMYCIN
英文摘要

Determination of neomycin is important for quality control of the pharmaceutical preparation. A quadruple-potential waveform used for pulsed amperometric detection of neomycin was investigated. The waveform cleans the electrode by application of a potential more negative than the potential limit to avoid the formation of gold oxide during applying positive potential to clean gold electrode, thus decreasing the dissolution resulting recession of the gold working electrode within gold oxide formation/reduction cycles in the triple-potential waveform. Waveform parameters were optimized to maximize the signal-to-noise ratio (S/N). The detection limit of neomycin B is lower than 0.01 mug/ml. The linearity of framycetin (plotted as peak area of neomycin B) ranges from 0.05 to 100 mug/ml with correlation coefficient 0.9998. R.S.D. (it = 60) of the peak area of neomycin B is lower than 2%. The quadruple-potential waveform shows low detection limits and long-term reproducibility. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000221769000007
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53155
专题北京大学药学院_化学生物学系
作者单位1.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China
2.Peking Univ, Ctr Hlth Sci, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
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Ding, YS,Yu, H,Mou, SF. Optimizing the quadruple-potential waveform for the pulsed amperometric detection of neomycin[J]. JOURNAL OF CHROMATOGRAPHY A,2004,1039(1-2):39-43.
APA Ding, YS,Yu, H,&Mou, SF.(2004).Optimizing the quadruple-potential waveform for the pulsed amperometric detection of neomycin.JOURNAL OF CHROMATOGRAPHY A,1039(1-2),39-43.
MLA Ding, YS,et al."Optimizing the quadruple-potential waveform for the pulsed amperometric detection of neomycin".JOURNAL OF CHROMATOGRAPHY A 1039.1-2(2004):39-43.
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