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学科主题: 基础医学
题名:
Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area
作者: Hu, Ling1; Chu, Ning-ning1; Sun, Lin-lin1; Zhang, Rong1; Han, Ji-Sheng1; Cui, Cai-lian1
关键词: Conditioned place preference (CPP) ; dopamine neurons ; electroacupuncture (EA) ; extracellular recording morphine ; ventral tegmental area
刊名: ADDICTION BIOLOGY
发表日期: 2009-10-01
DOI: 10.1111/j.1369-1600.2009.00163.x
卷: 14, 期:4, 页:431-437
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Substance Abuse
研究领域[WOS]: Biochemistry & Molecular Biology ; Substance Abuse
关键词[WOS]: COCAINE ADDICTION ; WITHDRAWAL ; RATS ; ELECTROPHYSIOLOGY ; IDENTIFICATION ; MECHANISMS ; REDUCTION ; RELEASE ; SYSTEM ; OPIATE
英文摘要:

Chronic morphine administration decreases the size of dopamine (DA) neurons in the ventral tegmental area (VTA). These transient morphological changes are accompanied by a reduced sensitivity of morphine-induced conditioned place preference (CPP) after chronic exposure to the drug. In this study we examined alterations in the firing rate of DAergic neurons by means of extracellular recording following chronic morphine exposure and applied 100 Hz electroacupuncture (EA) treatment to reverse the reduced firing rate of these neurons. In the first set of experiments we show that in rats, which received chronic morphine treatment for 14 days, a small dose of morphine was not able to induce a CPP response anymore. However, the sensitivity to morphine was reinstated by consecutive EA treatment for 10 days. The electrophysiological response of VTA DA neurons to morphine was markedly reduced in chronic morphine-treated rats compared to saline-treated controls. A substantial recovery of the reactivity of VTA DA neurons to morphine was observed in rats that received 100 Hz EA for 10 days. Our findings suggest that 100 Hz EA is a potential therapy for the treatment of opiate addiction by normalizing the activity of VTA DA neurons.

语种: 英语
所属项目编号: 2009CB522003 ; 30801491
项目资助者: National Basic Research Program ; National Natural Science Foundation of China
WOS记录号: WOS:000269674600007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53157
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing, Peoples R China

Recommended Citation:
Hu, Ling,Chu, Ning-ning,Sun, Lin-lin,et al. Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area[J]. ADDICTION BIOLOGY,2009,14(4):431-437.
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