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Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area
Hu, Ling1; Chu, Ning-ning1; Sun, Lin-lin1; Zhang, Rong1; Han, Ji-Sheng1; Cui, Cai-lian1
关键词Conditioned Place Preference (Cpp) Dopamine Neurons Electroacupuncture (Ea) Extracellular Recording Morphine Ventral Tegmental Area
刊名ADDICTION BIOLOGY
2009-10-01
DOI10.1111/j.1369-1600.2009.00163.x
14期:4页:431-437
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Substance Abuse
研究领域[WOS]Biochemistry & Molecular Biology ; Substance Abuse
关键词[WOS]COCAINE ADDICTION ; WITHDRAWAL ; RATS ; ELECTROPHYSIOLOGY ; IDENTIFICATION ; MECHANISMS ; REDUCTION ; RELEASE ; SYSTEM ; OPIATE
英文摘要

Chronic morphine administration decreases the size of dopamine (DA) neurons in the ventral tegmental area (VTA). These transient morphological changes are accompanied by a reduced sensitivity of morphine-induced conditioned place preference (CPP) after chronic exposure to the drug. In this study we examined alterations in the firing rate of DAergic neurons by means of extracellular recording following chronic morphine exposure and applied 100 Hz electroacupuncture (EA) treatment to reverse the reduced firing rate of these neurons. In the first set of experiments we show that in rats, which received chronic morphine treatment for 14 days, a small dose of morphine was not able to induce a CPP response anymore. However, the sensitivity to morphine was reinstated by consecutive EA treatment for 10 days. The electrophysiological response of VTA DA neurons to morphine was markedly reduced in chronic morphine-treated rats compared to saline-treated controls. A substantial recovery of the reactivity of VTA DA neurons to morphine was observed in rats that received 100 Hz EA for 10 days. Our findings suggest that 100 Hz EA is a potential therapy for the treatment of opiate addiction by normalizing the activity of VTA DA neurons.

语种英语
WOS记录号WOS:000269674600007
项目编号2009CB522003 ; 30801491
资助机构National Basic Research Program ; National Natural Science Foundation of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53157
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing, Peoples R China
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GB/T 7714
Hu, Ling,Chu, Ning-ning,Sun, Lin-lin,et al. Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area[J]. ADDICTION BIOLOGY,2009,14(4):431-437.
APA Hu, Ling,Chu, Ning-ning,Sun, Lin-lin,Zhang, Rong,Han, Ji-Sheng,&Cui, Cai-lian.(2009).Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area.ADDICTION BIOLOGY,14(4),431-437.
MLA Hu, Ling,et al."Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area".ADDICTION BIOLOGY 14.4(2009):431-437.
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