IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Nonmalignant Late Effects in Survivors of Partially Matched Donor Hematopoietic Stem Cell Transplantation
Mo, Xiao-Dong1; Xu, Lan-Ping1; Liu, Dai-Hong1; Zhang, Xiao-Hui1; Chen, Huan1; Chen, Yu-Hong1; Han, Wei1; Wang, Yu1; Wang, Feng-Rong1; Wang, Jing-Zhi1; Liu, Kai-Yan1; Huang, Xiao-Jun1,2
关键词Late Effects Hematopoietic Stem Cell Transplantation Allogeneic Graft-versus-host Disease Antithymocyte Globulin
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2013-05-01
DOI10.1016/j.bbmt.2013.01.026
19期:5页:777-783
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
资助者National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China ; National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; IDENTICAL SIBLING TRANSPLANTATION ; LONG-TERM SURVIVORS ; ANTITHYMOCYTE GLOBULIN ; EUROPEAN-GROUP ; ACUTE-LEUKEMIA ; CARDIOVASCULAR EVENTS ; SOCIETE FRANCAISE
英文摘要

Human leukocyte antigen (HLA) partially matched related donor (PMRD) hematopoietic stem cell transplantation (HSCT) is an effective option for hematological malignancies. In this study, the nonmalignant late effects of PMRD HSCT were evaluated and compared with HLA-identical sibling donor (ISD) HSCT. Three hundred thirteen patients (ISD, n = 160; PMRD, n = 153) who survived at least 6 months and received regular follow-up examinations after their HSCT were enrolled. The 5-year cumulative incidence (+/- SE) of at least one late effect and multiple late effects was 47.30%+/-.17% versus 58.21%+/-.16% (P = .134) and 17.97%+/-.10% versus 34.28%+/-.15% (P = .001) for PMRD HSCT recipients versus ISD HSCT recipients, respectively. The cumulative incidence of keratoconjunctivitis sicca, periodontitis, ankylosis, myalgia, and nephrotic syndrome was lower among PMRD HSCT recipients compared with ISD HSCT recipients. Severe chronic graft-versus-host disease, multiple pre-HSCT chemotherapy cycles, female donor, and older age were risk factors for at least one late effect. Female donor, older age, and long-term immunosuppressive therapy were associated with multiple late effects. In summary, PMRD HSCT recipients have a lower risk of late effects compared with ISD HSCT recipients, possibly due to differences in protocols for graft-versus-host disease prophylaxis, and long-term follow-up after transplantation is recommended. (C) 2013 American Society for Blood and Marrow Transplantation.

语种英语
所属项目编号2011AA020105 ; 81230013
资助者National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China ; National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China
WOS记录号WOS:000318132500015
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53163
Collection北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Mo, Xiao-Dong,Xu, Lan-Ping,Liu, Dai-Hong,et al. Nonmalignant Late Effects in Survivors of Partially Matched Donor Hematopoietic Stem Cell Transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2013,19(5):777-783.
APA Mo, Xiao-Dong.,Xu, Lan-Ping.,Liu, Dai-Hong.,Zhang, Xiao-Hui.,Chen, Huan.,...&Huang, Xiao-Jun.(2013).Nonmalignant Late Effects in Survivors of Partially Matched Donor Hematopoietic Stem Cell Transplantation.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,19(5),777-783.
MLA Mo, Xiao-Dong,et al."Nonmalignant Late Effects in Survivors of Partially Matched Donor Hematopoietic Stem Cell Transplantation".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 19.5(2013):777-783.
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