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学科主题: 临床医学
题名:
Nonmalignant Late Effects in Survivors of Partially Matched Donor Hematopoietic Stem Cell Transplantation
作者: Mo, Xiao-Dong1; Xu, Lan-Ping1; Liu, Dai-Hong1; Zhang, Xiao-Hui1; Chen, Huan1; Chen, Yu-Hong1; Han, Wei1; Wang, Yu1; Wang, Feng-Rong1; Wang, Jing-Zhi1; Liu, Kai-Yan1; Huang, Xiao-Jun1,2
关键词: Late effects ; Hematopoietic stem cell transplantation ; Allogeneic ; Graft-versus-host disease ; Antithymocyte globulin
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2013-05-01
DOI: 10.1016/j.bbmt.2013.01.026
卷: 19, 期:5, 页:777-783
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; IDENTICAL SIBLING TRANSPLANTATION ; LONG-TERM SURVIVORS ; ANTITHYMOCYTE GLOBULIN ; EUROPEAN-GROUP ; ACUTE-LEUKEMIA ; CARDIOVASCULAR EVENTS ; SOCIETE FRANCAISE
英文摘要:

Human leukocyte antigen (HLA) partially matched related donor (PMRD) hematopoietic stem cell transplantation (HSCT) is an effective option for hematological malignancies. In this study, the nonmalignant late effects of PMRD HSCT were evaluated and compared with HLA-identical sibling donor (ISD) HSCT. Three hundred thirteen patients (ISD, n = 160; PMRD, n = 153) who survived at least 6 months and received regular follow-up examinations after their HSCT were enrolled. The 5-year cumulative incidence (+/- SE) of at least one late effect and multiple late effects was 47.30%+/-.17% versus 58.21%+/-.16% (P = .134) and 17.97%+/-.10% versus 34.28%+/-.15% (P = .001) for PMRD HSCT recipients versus ISD HSCT recipients, respectively. The cumulative incidence of keratoconjunctivitis sicca, periodontitis, ankylosis, myalgia, and nephrotic syndrome was lower among PMRD HSCT recipients compared with ISD HSCT recipients. Severe chronic graft-versus-host disease, multiple pre-HSCT chemotherapy cycles, female donor, and older age were risk factors for at least one late effect. Female donor, older age, and long-term immunosuppressive therapy were associated with multiple late effects. In summary, PMRD HSCT recipients have a lower risk of late effects compared with ISD HSCT recipients, possibly due to differences in protocols for graft-versus-host disease prophylaxis, and long-term follow-up after transplantation is recommended. (C) 2013 American Society for Blood and Marrow Transplantation.

语种: 英语
所属项目编号: 2011AA020105 ; 81230013
项目资助者: National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China
WOS记录号: WOS:000318132500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53163
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China

Recommended Citation:
Mo, Xiao-Dong,Xu, Lan-Ping,Liu, Dai-Hong,et al. Nonmalignant Late Effects in Survivors of Partially Matched Donor Hematopoietic Stem Cell Transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2013,19(5):777-783.
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