IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Expression of midkine and its clinical significance in esophageal squamous cell carcinoma
Ren, Ying-Jia1; Zhang, Qing-Yun1
关键词Midkine Esophageal Squamous Cell Carcinoma Expression
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2006-04-07
12期:13页:2006-2010
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]SITU HYBRIDIZATION ANALYSES ; ACID RESPONSIVE GENE ; MOUSE EMBRYOGENESIS ; BLADDER-CANCER ; THERAPY ; OVEREXPRESSION ; PROGRESSION ; MARKER ; TUMORS ; MK
英文摘要

Aim: To investigate the expression of midkine in esophageal squamous cell carcinoma (ESCC) and analyze its relationship with clinicopathological features.

Methods: RT-PCR and immunocytochemical staining were used to detect the expression of midkine mRNA and protein in EC109 cells, respectively. Then the expression of midkine in 66 cases of ESCC samples were detected by immunohistochemistry using monoclonal antibodies against human midkine.

Results: Midkine was expressed in EC109 cell by RTPCR and immunocytochemistry. The immunoreactivity was detected in 56.1% (37/66) of the ESCC samples. The expression of midkine was found in cytoplasm of tumor cells. Notably, the intensity of midkine was stronger at the area abundant in vessels and the invading border of the tumors. Midkine was more intensely expressed in well differentiated tumors (76.9%) than in moderately and poorly differentiated tumors (43.1% and 41.2%, respectively) (P<0.05). There was no statistically significant correlation between midkine expression and gender, age, clinical stage, lymph node metastasis or survival in ESCC.

Conclusion: Midkine is overexpressed in ESCC. It may play a role in tumor angiogenesis and invasion. The expression of midkine is correlated with tumor cell differentiation in ESCC. The more poorly tumor cells differentiate, the weaker midkine expresses. (C) 2006 The WJG Press. All rights reserved.

语种英语
WOS记录号WOS:000239996100004
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53165
Collection北京大学临床肿瘤学院
作者单位1.Beijing Canc Hosp, Dept Lab Med, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Dept Immunol, Beijing Inst Canc Res, Beijing 100036, Peoples R China
Recommended Citation
GB/T 7714
Ren, Ying-Jia,Zhang, Qing-Yun. Expression of midkine and its clinical significance in esophageal squamous cell carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2006,12(13):2006-2010.
APA Ren, Ying-Jia,&Zhang, Qing-Yun.(2006).Expression of midkine and its clinical significance in esophageal squamous cell carcinoma.WORLD JOURNAL OF GASTROENTEROLOGY,12(13),2006-2010.
MLA Ren, Ying-Jia,et al."Expression of midkine and its clinical significance in esophageal squamous cell carcinoma".WORLD JOURNAL OF GASTROENTEROLOGY 12.13(2006):2006-2010.
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