IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科
学科主题临床医学
Overexpressed Rce1 is positively correlated with tumor progression and predicts poor prognosis in prostate cancer
Huang, Liangliang1; Li, Meicai1; Wang, Delin1; He, Jiang2; Wu, Wenqiang3; Zeng, Qiangfeng1; Li, Jianjun1; Xiao, Maolin1; Hu, Jie1; He, Yunfeng1; Li, Ying4; Mai, Li5; Liu, Wujiang6
关键词Biomarkers Prostate Prostate Cancer Rce1 Prognosis
刊名HUMAN PATHOLOGY
2016
DOI10.1016/j.humpath.2015.08.021
47期:1页:109-114
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]A-FACTOR ; RAS ; CELLS ; GROWTH ; TRANSFORMATION ; EXPRESSION ; NOMOGRAM ; DISEASE
英文摘要

Ras and a-factor-converting enzyme 1 (Rce1) have been reported to play a key role in the proteolysis processing of Ras proteins. The present study investigated the prognostic significance of Rce1 in patients with prostate cancer (PCa). The expressions of the mRNA and protein of Rce1 were analyzed in 12 pairs of PCa and benign prostatic hyperplasia (BPH) by quantitative real-time polymerase chain reaction and Western blotting, respectively. Immunohistochemistry was used to examine expression of Rce1 protein in 74 PCa tissues and 30 BPH tissues. The association between Rce1 expression and the specific clinicopathologic features was evaluated by chi(2) tests. Kaplan-Meier and Cox proportional hazards regression models were used to analyze the data. We found that expression of Rce1 mRNA and protein was markedly higher in PCa tissues than in paired BPH tissues. Expression of Rce1 in PCa was strongly associated with clinicopathologic features. It was detected in 69 (93.24%) of 74 PCa tissues by immunohistochemistry, and it was found to be associated with Gleason score (P = .013), T class (P = .015), and distant metastasis (P = .044). Patients with PCa having higher Rce1 expression had substantially shorter survival times than patients with lower Rce1 expression. Univariate and multivariate analysis revealed that Rce1 was an independent prognostic factor. In conclusion, our study suggests that expression of Rce1 can serve as an independent biomarker for the prognosis of PCa patients. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000366868500015
项目编号30972999 ; CSTC2012JJA10162 ; 20132082 ; 20143061
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Chongqing ; Health Bureau of Chongqing ; Health and Family Planning Commission Foundation of Chongqing
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53174
专题北京大学第一临床医学院_泌尿外科
作者单位1.Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing 400016, Chongqing, Peoples R China
2.Chongqing Med Univ, Univ Town Hosp, Gastroenterol & Neurol Ctr, Chongqing 401331, Peoples R China
3.Chongqing Med Univ, Affiliated Hosp 1, Qijiang Peoples Hosp, Dept Urol, Chongqing 400016, Peoples R China
4.Chongqing Med Univ, Coll Life Sci, Chongqing 400016, Peoples R China
5.Chongqing Med Univ, Mol Med & Canc Res Ctr, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China
6.Peking Univ, Affiliated Hosp 1, Inst Urol, Beijing 100000, Peoples R China
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Huang, Liangliang,Li, Meicai,Wang, Delin,et al. Overexpressed Rce1 is positively correlated with tumor progression and predicts poor prognosis in prostate cancer[J]. HUMAN PATHOLOGY,2016,47(1):109-114.
APA Huang, Liangliang.,Li, Meicai.,Wang, Delin.,He, Jiang.,Wu, Wenqiang.,...&Liu, Wujiang.(2016).Overexpressed Rce1 is positively correlated with tumor progression and predicts poor prognosis in prostate cancer.HUMAN PATHOLOGY,47(1),109-114.
MLA Huang, Liangliang,et al."Overexpressed Rce1 is positively correlated with tumor progression and predicts poor prognosis in prostate cancer".HUMAN PATHOLOGY 47.1(2016):109-114.
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