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学科主题: 临床医学
题名:
Overexpressed Rce1 is positively correlated with tumor progression and predicts poor prognosis in prostate cancer
作者: Huang, Liangliang1; Li, Meicai1; Wang, Delin1; He, Jiang2; Wu, Wenqiang3; Zeng, Qiangfeng1; Li, Jianjun1; Xiao, Maolin1; Hu, Jie1; He, Yunfeng1; Li, Ying4; Mai, Li5; Liu, Wujiang6
关键词: Biomarkers ; Prostate ; Prostate cancer ; Rce1 ; Prognosis
刊名: HUMAN PATHOLOGY
发表日期: 2016
DOI: 10.1016/j.humpath.2015.08.021
卷: 47, 期:1, 页:109-114
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: A-FACTOR ; RAS ; CELLS ; GROWTH ; TRANSFORMATION ; EXPRESSION ; NOMOGRAM ; DISEASE
英文摘要:

Ras and a-factor-converting enzyme 1 (Rce1) have been reported to play a key role in the proteolysis processing of Ras proteins. The present study investigated the prognostic significance of Rce1 in patients with prostate cancer (PCa). The expressions of the mRNA and protein of Rce1 were analyzed in 12 pairs of PCa and benign prostatic hyperplasia (BPH) by quantitative real-time polymerase chain reaction and Western blotting, respectively. Immunohistochemistry was used to examine expression of Rce1 protein in 74 PCa tissues and 30 BPH tissues. The association between Rce1 expression and the specific clinicopathologic features was evaluated by chi(2) tests. Kaplan-Meier and Cox proportional hazards regression models were used to analyze the data. We found that expression of Rce1 mRNA and protein was markedly higher in PCa tissues than in paired BPH tissues. Expression of Rce1 in PCa was strongly associated with clinicopathologic features. It was detected in 69 (93.24%) of 74 PCa tissues by immunohistochemistry, and it was found to be associated with Gleason score (P = .013), T class (P = .015), and distant metastasis (P = .044). Patients with PCa having higher Rce1 expression had substantially shorter survival times than patients with lower Rce1 expression. Univariate and multivariate analysis revealed that Rce1 was an independent prognostic factor. In conclusion, our study suggests that expression of Rce1 can serve as an independent biomarker for the prognosis of PCa patients. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30972999 ; CSTC2012JJA10162 ; 20132082 ; 20143061
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Chongqing ; Health Bureau of Chongqing ; Health and Family Planning Commission Foundation of Chongqing
WOS记录号: WOS:000366868500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53174
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing 400016, Chongqing, Peoples R China
2.Chongqing Med Univ, Univ Town Hosp, Gastroenterol & Neurol Ctr, Chongqing 401331, Peoples R China
3.Chongqing Med Univ, Affiliated Hosp 1, Qijiang Peoples Hosp, Dept Urol, Chongqing 400016, Peoples R China
4.Chongqing Med Univ, Coll Life Sci, Chongqing 400016, Peoples R China
5.Chongqing Med Univ, Mol Med & Canc Res Ctr, Dept Biochem & Mol Biol, Chongqing 400016, Peoples R China
6.Peking Univ, Affiliated Hosp 1, Inst Urol, Beijing 100000, Peoples R China

Recommended Citation:
Huang, Liangliang,Li, Meicai,Wang, Delin,et al. Overexpressed Rce1 is positively correlated with tumor progression and predicts poor prognosis in prostate cancer[J]. HUMAN PATHOLOGY,2016,47(1):109-114.
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