北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Triptolide inhibits amyloid-beta 1-42-induced TNF-alpha and IL-1 beta production in cultured rat microglia
作者: Jiao, Jian2,3,4; Xue, Bing2,3; Zhang, Lei1; Gong, Yuntao2,3; Li, Kairong2,3; Wang, Haomin2,3; Jing, Liming2,3; Xie, Junxia4; Wang, Xiaomin1,2,3
关键词: Triptolide ; Amyloid-beta (A beta) ; Microglia ; Inflammation ; Pro-inflammatory cytokines
刊名: JOURNAL OF NEUROIMMUNOLOGY
发表日期: 2008-12-15
DOI: 10.1016/j.jneuroim.2008.08.006
卷: 205, 期:1-2, 页:32-36
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Neurosciences
研究领域[WOS]: Immunology ; Neurosciences & Neurology
关键词[WOS]: LONG-TERM POTENTIATION ; INDUCED GLIAL ACTIVATION ; AMYLOID-BETA-PEPTIDE ; ALZHEIMERS-DISEASE ; INFLAMMATION ; NEUROINFLAMMATION ; NEURODEGENERATION ; PROGRESSION ; OLIGOMERS ; CYTOKINE
英文摘要:

Microglia plays an important role in mediating neuroinflammation in Alzheimer′s disease (AD). Intervention in microglia activation may exert a neuroprotective effect. In the present study, we reported that oligomeric A beta 1-42 dramatically increased the level of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta compared to monomeric and fibrillar A beta 1-42 in rat microglial Cultures. Pretreatment of the cultures with triptolide, an anti-inflammatory reagent, alleviated the elevation of TNF-alpha and IL-1 beta, level induced by oligomeric A beta 1-42. Our results showed that oligomeric A beta played an important role in mediating neuroinflammation and triptolide was able to suppress the production of pro-inflammatory cytokines from microglia. (C) 2008 Published by Elsevier B.V.

语种: 英语
所属项目编号: 2006CB500700 ; 30571704
项目资助者: National Basic Research Program of China ; NSFC
WOS记录号: WOS:000261902200006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53175
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Triptolide inhibits amyloid-beta 1-42-induced TNF-alpha and IL-1 beta production in cultured rat microglia.pdf(557KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Capital Med Univ, Dept Physiol, Minist Educ, Key Lab Neurodegenerat Disorders, Beijing 100069, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Neurosci, Neurosci Res Inst, Beijing 100083, Peoples R China
3.Peking Univ, Minist Educ, Key Lab Neurosci, Dept Neurobiol, Beijing 100083, Peoples R China
4.Qingdao Univ, Coll Med, Dept Physiol, Qingdao 266071, Peoples R China

Recommended Citation:
Jiao, Jian,Xue, Bing,Zhang, Lei,et al. Triptolide inhibits amyloid-beta 1-42-induced TNF-alpha and IL-1 beta production in cultured rat microglia[J]. JOURNAL OF NEUROIMMUNOLOGY,2008,205(1-2):32-36.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jiao, Jian]'s Articles
[Xue, Bing]'s Articles
[Zhang, Lei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jiao, Jian]‘s Articles
[Xue, Bing]‘s Articles
[Zhang, Lei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace