北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
Triptolide inhibits amyloid-beta 1-42-induced TNF-alpha and IL-1 beta production in cultured rat microglia
作者: Jiao, Jian2,3,4; Xue, Bing2,3; Zhang, Lei1; Gong, Yuntao2,3; Li, Kairong2,3; Wang, Haomin2,3; Jing, Liming2,3; Xie, Junxia4; Wang, Xiaomin1,2,3
关键词: Triptolide ; Amyloid-beta (A beta) ; Microglia ; Inflammation ; Pro-inflammatory cytokines
刊名: JOURNAL OF NEUROIMMUNOLOGY
发表日期: 2008-12-15
DOI: 10.1016/j.jneuroim.2008.08.006
卷: 205, 期:1-2, 页:32-36
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Neurosciences
研究领域[WOS]: Immunology ; Neurosciences & Neurology
关键词[WOS]: LONG-TERM POTENTIATION ; INDUCED GLIAL ACTIVATION ; AMYLOID-BETA-PEPTIDE ; ALZHEIMERS-DISEASE ; INFLAMMATION ; NEUROINFLAMMATION ; NEURODEGENERATION ; PROGRESSION ; OLIGOMERS ; CYTOKINE
英文摘要:

Microglia plays an important role in mediating neuroinflammation in Alzheimer′s disease (AD). Intervention in microglia activation may exert a neuroprotective effect. In the present study, we reported that oligomeric A beta 1-42 dramatically increased the level of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta compared to monomeric and fibrillar A beta 1-42 in rat microglial Cultures. Pretreatment of the cultures with triptolide, an anti-inflammatory reagent, alleviated the elevation of TNF-alpha and IL-1 beta, level induced by oligomeric A beta 1-42. Our results showed that oligomeric A beta played an important role in mediating neuroinflammation and triptolide was able to suppress the production of pro-inflammatory cytokines from microglia. (C) 2008 Published by Elsevier B.V.

语种: 英语
所属项目编号: 2006CB500700 ; 30571704
项目资助者: National Basic Research Program of China ; NSFC
WOS记录号: WOS:000261902200006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53175
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Triptolide inhibits amyloid-beta 1-42-induced TNF-alpha and IL-1 beta production in cultured rat microglia.pdf(557KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Capital Med Univ, Dept Physiol, Minist Educ, Key Lab Neurodegenerat Disorders, Beijing 100069, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Neurosci, Neurosci Res Inst, Beijing 100083, Peoples R China
3.Peking Univ, Minist Educ, Key Lab Neurosci, Dept Neurobiol, Beijing 100083, Peoples R China
4.Qingdao Univ, Coll Med, Dept Physiol, Qingdao 266071, Peoples R China

Recommended Citation:
Jiao, Jian,Xue, Bing,Zhang, Lei,et al. Triptolide inhibits amyloid-beta 1-42-induced TNF-alpha and IL-1 beta production in cultured rat microglia[J]. JOURNAL OF NEUROIMMUNOLOGY,2008,205(1-2):32-36.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jiao, Jian]'s Articles
[Xue, Bing]'s Articles
[Zhang, Lei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jiao, Jian]‘s Articles
[Xue, Bing]‘s Articles
[Zhang, Lei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace