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学科主题基础医学
Triptolide inhibits amyloid-beta 1-42-induced TNF-alpha and IL-1 beta production in cultured rat microglia
Jiao, Jian2,3,4; Xue, Bing2,3; Zhang, Lei1; Gong, Yuntao2,3; Li, Kairong2,3; Wang, Haomin2,3; Jing, Liming2,3; Xie, Junxia4; Wang, Xiaomin1,2,3
关键词Triptolide Amyloid-Beta (a Beta) Microglia Inflammation Pro-inflammatory Cytokines
刊名JOURNAL OF NEUROIMMUNOLOGY
2008-12-15
DOI10.1016/j.jneuroim.2008.08.006
205期:1-2页:32-36
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Neurosciences
研究领域[WOS]Immunology ; Neurosciences & Neurology
关键词[WOS]LONG-TERM POTENTIATION ; INDUCED GLIAL ACTIVATION ; AMYLOID-BETA-PEPTIDE ; ALZHEIMERS-DISEASE ; INFLAMMATION ; NEUROINFLAMMATION ; NEURODEGENERATION ; PROGRESSION ; OLIGOMERS ; CYTOKINE
英文摘要

Microglia plays an important role in mediating neuroinflammation in Alzheimer′s disease (AD). Intervention in microglia activation may exert a neuroprotective effect. In the present study, we reported that oligomeric A beta 1-42 dramatically increased the level of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta compared to monomeric and fibrillar A beta 1-42 in rat microglial Cultures. Pretreatment of the cultures with triptolide, an anti-inflammatory reagent, alleviated the elevation of TNF-alpha and IL-1 beta, level induced by oligomeric A beta 1-42. Our results showed that oligomeric A beta played an important role in mediating neuroinflammation and triptolide was able to suppress the production of pro-inflammatory cytokines from microglia. (C) 2008 Published by Elsevier B.V.

语种英语
WOS记录号WOS:000261902200006
项目编号2006CB500700 ; 30571704
资助机构National Basic Research Program of China ; NSFC
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53175
专题北京大学基础医学院_神经生物学系
北京大学第一临床医学院_口腔科
作者单位1.Capital Med Univ, Dept Physiol, Minist Educ, Key Lab Neurodegenerat Disorders, Beijing 100069, Peoples R China
2.Peking Univ, Minist Educ, Key Lab Neurosci, Neurosci Res Inst, Beijing 100083, Peoples R China
3.Peking Univ, Minist Educ, Key Lab Neurosci, Dept Neurobiol, Beijing 100083, Peoples R China
4.Qingdao Univ, Coll Med, Dept Physiol, Qingdao 266071, Peoples R China
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GB/T 7714
Jiao, Jian,Xue, Bing,Zhang, Lei,et al. Triptolide inhibits amyloid-beta 1-42-induced TNF-alpha and IL-1 beta production in cultured rat microglia[J]. JOURNAL OF NEUROIMMUNOLOGY,2008,205(1-2):32-36.
APA Jiao, Jian.,Xue, Bing.,Zhang, Lei.,Gong, Yuntao.,Li, Kairong.,...&Wang, Xiaomin.(2008).Triptolide inhibits amyloid-beta 1-42-induced TNF-alpha and IL-1 beta production in cultured rat microglia.JOURNAL OF NEUROIMMUNOLOGY,205(1-2),32-36.
MLA Jiao, Jian,et al."Triptolide inhibits amyloid-beta 1-42-induced TNF-alpha and IL-1 beta production in cultured rat microglia".JOURNAL OF NEUROIMMUNOLOGY 205.1-2(2008):32-36.
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