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学科主题: 临床医学
题名:
Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms
作者: Liu Ming1; Wang Jianye1; Yang Yong2; An Ruihua3; Wen Jianguo4; Guan Zhichen5; Zheng Shaobin6; Wang Dongwen7; Song Bo8; Liao Limin9; Guo Hongqian10; Xiao Jiaquan11; Sun Yinghao12; Shen Zhoujun13; Kong Chuize14; He Dalin15; Huang Yiran16; Wang Xiaofeng17; Zhang Xu18; Li Hanzhong19; Huang Jian20; Zhao Xiaokun21; Zeng Puqing22; Song Xishuang23; Ye Zhangqun24
关键词: overactive bladder ; muscarinic antagonists ; symptom score
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-01-20
DOI: 10.3760/cma.j.issn.0366-6999.20131349
卷: 127, 期:2, 页:261-265
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: PLACEBO-CONTROLLED TRIAL ; URINARY-TRACT SYMPTOMS ; DOUBLE-BLIND ; TOLTERODINE ; URGENCY ; INCONTINENCE ; TOLERABILITY ; SUCCINATE ; SEVERITY ; IMPROVES
英文摘要:

Background Overactive bladder (OAB) is a series of symptoms with high prevalence in elderly people. This study was conducted using the overactive bladder symptom score (OABSS) to evaluate the efficacy of solifenacin succinate for the treatment of OAB.

Methods This was a prospective, multicenter, single-arm, 12-week study that enrolled 241 OAB patients. The patients received 5-10 mg/day solifenacin. Changes in OABSS, symptoms from voiding diary, perception of bladder condition (PPBC) score, international prostate symptom score (IPSS) and quality of life (QOL) were evaluated at weeks 0, 4, and 12. The relationship between OABSS and PPBC score or parameters of voiding diary was also evaluated.

Results At baseline, the mean OABSS for all patients was 9.41 +/- 2.40, and was reduced significantly at week 12 (-3.76 points; 61.21%, P <0.0001). The OABSS subscore, PPBC score, IPSS, and QOL were also significantly reduced during the study (P <0.0001). The overall incidence of adverse events was 19.91% (44 cases). The gastrointestinal system was the most commonly affected (11.31%). Around 5.88% of the cases had adverse events related to the genitourinary system. There was a strong correlation between OABSS and urinary symptoms that was recorded in the 3-day voiding dairy.

Conclusions We showed that solifenacin was clinically effective for relieving OAB symptoms, considering the balance between efficacy, patients′ well-being, and tolerability. OABSS integrates four OAB symptoms into a single score and can be a useful tool for research and clinical practice.

语种: 英语
项目资助者: Astellas Pharma China, Ltd.
WOS记录号: WOS:000330606900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53176
Appears in Collections:北京大学深圳医院_泌尿外科_期刊论文

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作者单位: 1.Beijing Hosp, Dept Urol, Beijing 100730, Peoples R China
2.Beijing Chao Yang Hosp, Dept Urol, Beijing 100730, Peoples R China
3.Harbin Med Univ, Clin Coll 1, Dept Urol, Harbin 150001, Heilongjiang, Peoples R China
4.Zhengzhou Univ, Affiliated Hosp 1, Dept Urol, Zhengzhou 450003, Henan, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen 518036, Guangdong, Peoples R China
6.Nan Fang Hosp, Dept Urol, Guangzhou 440100, Guandong, Peoples R China
7.Shanxi Med Univ, Clin Coll 1, Dept Urol, Taiyuan 030012, Shanxi, Peoples R China
8.China Rehabil Ctr, Dept Urol, Beijing 100068, Peoples R China
9.Changhai Hosp Shanghai, Dept Urol, Shanghai 200433, Peoples R China
10.Southwest Hosp, Dept Urol, Chongqing 400038, Peoples R China
11.Nanjing Univ, Sch Med, Affiliated Hosp, Dept Urol,Nanjing Drum Tower Hosp, Nanjing 210008, Jiangsu, Peoples R China
12.Zhejiang Prov Peoples Hosp, Dept Urol, Hangzhou 310014, Zhejiang, Peoples R China
13.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Urol, Shanghai 200025, Peoples R China
14.China Med Univ, Hosp 1, Dept Urol, Shenyang 110001, Liaoning, Peoples R China
15.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Urol, Xian 710061, Shaanxi, Peoples R China
16.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Urol, Shanghai 200127, Peoples R China
17.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China
18.Gen Hosp Peoples Liberat Army, Dept Urol, Beijing 100039, Peoples R China
19.Beijing Union Med Coll Hosp, Dept Urol, Beijing 100005, Peoples R China
20.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Urol, Guangzhou 510120, Guangdong, Peoples R China
21.Cent S Univ, Xiangya Hosp 2, Dept Urol, Changsha 410011, Hunan, Peoples R China
22.Wuhan Union Hosp, Dept Urol, Wuhan 430022, Hubei, Peoples R China
23.Dalian Med Univ, Dept Urol, Affiliated Hosp 1, Dalian 116600, Liaoning, Peoples R China
24.Huazhong Univ Sci, Tongji Med Coll, Tongji Hosp, Dept Urol, Wuhan 430030, Hubei, Peoples R China

Recommended Citation:
Liu Ming,Wang Jianye,Yang Yong,et al. Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms[J]. CHINESE MEDICAL JOURNAL,2014,127(2):261-265.
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