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The further study on radioiodinated peptide Arg-Arg-Leu targeted to neovascularization as well as tumor cells in molecular tumor imaging
Lu, Xia; Yan, Ping; Wang, Rongfu; Liu, Meng; Yu, Mingming; Zhang, Chunli; Guo, Fengqing
关键词Iodine-131 Arg-arg-leu(Trrl) Uptake Ability Cytotoxicity Molecular Tumor Imaging
刊名JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
2011-12-01
DOI10.1007/s10967-011-1342-1
290期:3页:623-630
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology
研究领域[WOS]Chemistry ; Nuclear Science & Technology
关键词[WOS]ANGIOGENESIS ; THERAPY ; CANCER ; GROWTH ; SCINTIGRAPHY ; VASCULATURE ; METASTASIS ; ONCOLOGY ; SCIENCE
英文摘要

The importance of angiogenesis in tumor growth and metastasis has led to develop new imaging tracers to understand angiogenic vasculature. Based on the previous study, we further focused on the tumor molecular imaging application of the novel peptide Arginine-Arginine-Leucine (Tyr-Cys-Gly-Gly-Arg-Arg-Leu-Gly-Gly-Cys, tRRL) in this study. The cytotoxicity of raioiodinated tRRL (I-131-tRRL) in HepG2 cells was assessed by tested cell viability using kit. tRRL was conjugated with fluorescein FITC to observe its binding with tumor cells and human aortic endothelial cells (HAEC) in vitro. Whole body SPECT imaging of varied tumors xenograftes was performed after intravenous injection of I-131-tRRL for 24 h in BALB/c nude mice. Compared with negative control PBS, small peptide tRRL was of non-cytotoxicity. I-131-tRRL could lead to significant cytotoxicity on HepG2 cells when the radioactivity was greater than 370 kBq. In vitro binding experiment and cellular uptake results revealed that tRRL could adhere to tumor cells besides tumor derived endothelial cells. In vivo SPECT imaging, I-131-tRRL mainly accumulated in various tumor tissues, including melanoma, liver cancer and lung cancer bearing mice. In breast cancer xenografte imaging, the tumor has no significant radionuclide accumulation at 24 h after injected of I-131-tRRL. Radioiodinated tRRL offers a noninvasive nuclear imaging method for functional molecular imaging of tumors, and may be a promising candidate carrier for tumor targeted therapy.

语种英语
WOS记录号WOS:000296644500013
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53177
专题北京大学第一临床医学院_核医学科
北京大学口腔医学院_护理部
作者单位Peking Univ, Dept Nucl Med, Hosp 1, Beijing 100034, Peoples R China
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Lu, Xia,Yan, Ping,Wang, Rongfu,et al. The further study on radioiodinated peptide Arg-Arg-Leu targeted to neovascularization as well as tumor cells in molecular tumor imaging[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2011,290(3):623-630.
APA Lu, Xia.,Yan, Ping.,Wang, Rongfu.,Liu, Meng.,Yu, Mingming.,...&Guo, Fengqing.(2011).The further study on radioiodinated peptide Arg-Arg-Leu targeted to neovascularization as well as tumor cells in molecular tumor imaging.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,290(3),623-630.
MLA Lu, Xia,et al."The further study on radioiodinated peptide Arg-Arg-Leu targeted to neovascularization as well as tumor cells in molecular tumor imaging".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 290.3(2011):623-630.
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