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学科主题: 临床医学
题名:
Functional Recovery of Denervated Skeletal Muscle with Sensory or Mixed Nerve Protection: A Pilot Study
作者: Li, Qing Tian; Zhang, Pei Xun; Yin, Xiao Feng; Han, Na; Kou, Yu Hui; Deng, Jiu Xu; Jiang, Bao Guo
刊名: PLOS ONE
发表日期: 2013-11-07
DOI: 10.1371/journal.pone.0079746
卷: 8, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SCHWANN-CELL DENERVATION ; PERIPHERAL-NERVE ; NEUROTROPHIC FACTOR ; CONTRIBUTING FACTORS ; SATELLITE CELLS ; STEM-CELLS ; RAT MODEL ; REGENERATION ; REPAIR ; REINNERVATION
英文摘要:

Functional recovery is usually poor following peripheral nerve injury when reinnervation is delayed. Early innervation by sensory nerve has been indicated to prevent atrophy of the denervated muscle. It is hypothesized that early protection with sensory axons is adequate to improve functional recovery of skeletal muscle following prolonged denervation of mixed nerve injury. In this study, four groups of rats received surgical denervation of the tibial nerve. The proximal and distal stumps of the tibial nerve were ligated in all animals except for those in the immediate repair group. The experimental groups underwent denervation with nerve protection of peroneal nerve (mixed protection) or sural nerve (sensory protection). The experimental and unprotected groups had a stage II surgery in which the trimmed proximal and distal tibial nerve stumps were sutured together. After 3 months of recovery, electrophysiological, histological and morphometric parameters were assessed. It was detected that the significant muscle atrophy and a good preserved structure of the muscle were observed in the unprotected and protective experimental groups, respectively. Significantly fewer numbers of regenerated myelinated axons were observed in the sensory-protected group. Enhanced recovery in the mixed protection group was indicated by the results of the muscle contraction force tests, regenerated myelinated fiber, and the results of the histological analysis. Our results suggest that early axons protection by mixed nerve may complement sensory axons which are required for promoting functional recovery of the denervated muscle natively innervated by mixed nerve.

语种: 英语
所属项目编号: 31171150 ; 31271284 ; 81171146 ; 30971526 ; 30801169 ; A-2008-10 ; BMU 20110270 ; 2014CB542206 ; 31100860
项目资助者: National Natural Science Fund ; Beijing City Science and Technology New Star Classification ; Educational Ministry New Century Excellent Talents Support Project ; National 973 Program ; National Natural Science Youth Science Fund
WOS记录号: WOS:000327162900050
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53182
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Trauma & Orthopead, Beijing 100871, Peoples R China

Recommended Citation:
Li, Qing Tian,Zhang, Pei Xun,Yin, Xiao Feng,et al. Functional Recovery of Denervated Skeletal Muscle with Sensory or Mixed Nerve Protection: A Pilot Study[J]. PLOS ONE,2013,8(11).
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