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Genetic differentiation within the inbred C57BL/6J mouse strain
Niu, Y.1; Liang, S.2
关键词Genetic Differentiation Inbred Strain C57bl 6j Microsatellite Locus D-loop
刊名JOURNAL OF ZOOLOGY
2009-05-01
DOI10.1111/j.1469-7998.2008.00546.x
278期:1页:42-47
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Zoology
研究领域[WOS]Zoology
关键词[WOS]MICE ; EVOLUTION ; BEHAVIOR ; NUMBER ; SIZE
英文摘要

The C57BL/6J (B6) inbred mouse strain is commonly used in biomedical researches. However, some unexpected inconsistency was reported compared with previous studies, and in most cases, it can be attributed to environmental, epigenetic or stochastic differences. The goal of this study was to investigate the genetic stability of the B6 strain maintained in different breeders. B6 mice purchased from five Chinese commercial breeders were examined, and mitochondrial D-loop sequence and 18 microsatellite loci were genotyped. There is no difference in the D-loop sequences, but variations exist in the nucleic microsatellite markers. Combining the data from MGI_4.01, a significant divergence is observed among those mice. The present study indicates that different B6 mice share the common maternal lineage and are still inbred in each breeder, but subline divergence occurs.

语种英语
WOS记录号WOS:000265377400005
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53183
专题北京大学第二临床医学院
北京大学护理学院_护理学院
作者单位1.Peking Univ, Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Lab Anim Ctr, Beijing 100871, Peoples R China
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GB/T 7714
Niu, Y.,Liang, S.. Genetic differentiation within the inbred C57BL/6J mouse strain[J]. JOURNAL OF ZOOLOGY,2009,278(1):42-47.
APA Niu, Y.,&Liang, S..(2009).Genetic differentiation within the inbred C57BL/6J mouse strain.JOURNAL OF ZOOLOGY,278(1),42-47.
MLA Niu, Y.,et al."Genetic differentiation within the inbred C57BL/6J mouse strain".JOURNAL OF ZOOLOGY 278.1(2009):42-47.
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