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学科主题: 临床医学
题名:
Genetic differentiation within the inbred C57BL/6J mouse strain
作者: Niu, Y.1; Liang, S.2
关键词: genetic differentiation ; inbred strain ; C57BL ; 6J ; microsatellite locus ; D-loop
刊名: JOURNAL OF ZOOLOGY
发表日期: 2009-05-01
DOI: 10.1111/j.1469-7998.2008.00546.x
卷: 278, 期:1, 页:42-47
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Zoology
研究领域[WOS]: Zoology
关键词[WOS]: MICE ; EVOLUTION ; BEHAVIOR ; NUMBER ; SIZE
英文摘要:

The C57BL/6J (B6) inbred mouse strain is commonly used in biomedical researches. However, some unexpected inconsistency was reported compared with previous studies, and in most cases, it can be attributed to environmental, epigenetic or stochastic differences. The goal of this study was to investigate the genetic stability of the B6 strain maintained in different breeders. B6 mice purchased from five Chinese commercial breeders were examined, and mitochondrial D-loop sequence and 18 microsatellite loci were genotyped. There is no difference in the D-loop sequences, but variations exist in the nucleic microsatellite markers. Combining the data from MGI_4.01, a significant divergence is observed among those mice. The present study indicates that different B6 mice share the common maternal lineage and are still inbred in each breeder, but subline divergence occurs.

语种: 英语
所属项目编号: RDB2007-03
项目资助者: Peking University People&prime ; s Hospital
WOS记录号: WOS:000265377400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53183
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Lab Anim Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Niu, Y.,Liang, S.. Genetic differentiation within the inbred C57BL/6J mouse strain[J]. JOURNAL OF ZOOLOGY,2009,278(1):42-47.
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