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学科主题: 精神卫生
题名:
Diagnostic utility of neuropsychological performance and quantitative MRI-based measurement in Alzheimer disease
作者: Wang, HL1; Shu, L1; Xie, JX1; Zhang, HY1; Zhang, D1
关键词: Alzheimer disease ; vascular dementia ; cognitive impairment ; medial temporal lobe ; magnetic resonance imaging ; diagnosis
刊名: ALZHEIMER DISEASE & ASSOCIATED DISORDERS
发表日期: 2004-07-01
卷: 18, 期:3, 页:163-170
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Pathology
研究领域[WOS]: Neurosciences & Neurology ; Pathology
关键词[WOS]: ENTORHINAL CORTEX ; DEMENTIA ; HIPPOCAMPUS ; VOLUMES ; MEMORY ; SCALE ; TIME ; AGE ; AD
英文摘要:

This study was designed to examine the roles of the characteristic cognitive indicators and specific MRI-based measurements in the differential diagnoses of Alzheimer disease (AD), vascular dementia (VaD), and normal aging. Fifty-two probable AD patients were recruited for the study. Twenty-seven VaD patients and 35 age-matched normal older adults (NC) were included as controls. All subjects underwent a battery of standardized neuropsychological tests. The MRI-based quantification technique was used to measure the volumes and T2 relaxation time (T(2)) of medial temporal lobe structures. Stepwise discriminant analyses showed cognitive indicators had a sensitivity ranging from 82% to 100% and specificity from 82% to 97% for differentiating AD from non-AD cases (VaD and normal controls), and the quantitative MRI-based measurements of medial temporal lobe structures correctly classified AD cases from non-AD cases with sensitivity from 80% to 96% and specificity from 83% to 97%. ROC curve analyses showed that the combination of cognitive and MRI measurements slightly increased the diagnostic accuracy of AD. The results suggest that both cognitive indicators and MRI-based medial temporal lobe measurements may be useful in differentiating AD from VaD and normal older adults. The combination of these possible indicators is promising in the early diagnosis of AD.

语种: 英语
WOS记录号: WOS:000223835300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53189
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Dept Radiol, Beijing, Peoples R China
2.Peking Univ, Inst Mental Hlth, Dept Geriatr Psychiat, Beijing 100871, Peoples R China
3.Peking Univ, Inst Mental Hlth, Dept Clin Psychopharmacol, Beijing 100871, Peoples R China
4.Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92697 USA

Recommended Citation:
Wang, HL,Shu, L,Xie, JX,et al. Diagnostic utility of neuropsychological performance and quantitative MRI-based measurement in Alzheimer disease[J]. ALZHEIMER DISEASE & ASSOCIATED DISORDERS,2004,18(3):163-170.
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