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Diagnostic utility of neuropsychological performance and quantitative MRI-based measurement in Alzheimer disease
Wang, HL1; Shu, L1; Xie, JX1; Zhang, HY1; Zhang, D1
关键词Alzheimer Disease Vascular Dementia Cognitive Impairment Medial Temporal Lobe Magnetic Resonance Imaging Diagnosis
刊名ALZHEIMER DISEASE & ASSOCIATED DISORDERS
2004-07-01
18期:3页:163-170
收录类别SCI ; ISTP
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Pathology
研究领域[WOS]Neurosciences & Neurology ; Pathology
关键词[WOS]ENTORHINAL CORTEX ; DEMENTIA ; HIPPOCAMPUS ; VOLUMES ; MEMORY ; SCALE ; TIME ; AGE ; AD
英文摘要

This study was designed to examine the roles of the characteristic cognitive indicators and specific MRI-based measurements in the differential diagnoses of Alzheimer disease (AD), vascular dementia (VaD), and normal aging. Fifty-two probable AD patients were recruited for the study. Twenty-seven VaD patients and 35 age-matched normal older adults (NC) were included as controls. All subjects underwent a battery of standardized neuropsychological tests. The MRI-based quantification technique was used to measure the volumes and T2 relaxation time (T(2)) of medial temporal lobe structures. Stepwise discriminant analyses showed cognitive indicators had a sensitivity ranging from 82% to 100% and specificity from 82% to 97% for differentiating AD from non-AD cases (VaD and normal controls), and the quantitative MRI-based measurements of medial temporal lobe structures correctly classified AD cases from non-AD cases with sensitivity from 80% to 96% and specificity from 83% to 97%. ROC curve analyses showed that the combination of cognitive and MRI measurements slightly increased the diagnostic accuracy of AD. The results suggest that both cognitive indicators and MRI-based medial temporal lobe measurements may be useful in differentiating AD from VaD and normal older adults. The combination of these possible indicators is promising in the early diagnosis of AD.

语种英语
WOS记录号WOS:000223835300009
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53189
Collection北京大学精神卫生研究所
作者单位1.Peking Univ Third Hosp, Dept Radiol, Beijing, Peoples R China
2.Peking Univ, Inst Mental Hlth, Dept Geriatr Psychiat, Beijing 100871, Peoples R China
3.Peking Univ, Inst Mental Hlth, Dept Clin Psychopharmacol, Beijing 100871, Peoples R China
4.Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92697 USA
Recommended Citation
GB/T 7714
Wang, HL,Shu, L,Xie, JX,et al. Diagnostic utility of neuropsychological performance and quantitative MRI-based measurement in Alzheimer disease[J]. ALZHEIMER DISEASE & ASSOCIATED DISORDERS,2004,18(3):163-170.
APA Wang, HL,Shu, L,Xie, JX,Zhang, HY,&Zhang, D.(2004).Diagnostic utility of neuropsychological performance and quantitative MRI-based measurement in Alzheimer disease.ALZHEIMER DISEASE & ASSOCIATED DISORDERS,18(3),163-170.
MLA Wang, HL,et al."Diagnostic utility of neuropsychological performance and quantitative MRI-based measurement in Alzheimer disease".ALZHEIMER DISEASE & ASSOCIATED DISORDERS 18.3(2004):163-170.
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