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学科主题: 临床医学
题名:
Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer
作者: Shen, Zhanlong1,2; Ye, Yingjiang1; Dong, Lingyi1; Vainionpaa, Sanna2; Mustonen, Harri2; Puolakkainen, Pauli2; Wang, Shan1
关键词: Kindlin-2 ; Gastric cancer ; Invasion ; Metastasis ; Prognosis ; Therapy
刊名: AMERICAN JOURNAL OF SURGERY
发表日期: 2012-02-01
DOI: 10.1016/j.amjsurg.2011.06.050
卷: 203, 期:2, 页:222-229
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: CELL-MATRIX ADHESION ; KINDLER-SYNDROME ; INTEGRIN ACTIVATION ; MIGFILIN ; ADENOCARCINOMA ; LOCALIZATION ; CHEMOTHERAPY ; RECURRENCE ; CARCINOMA ; MIGRATION
英文摘要:

BACKGROUND: Kindlin-2 has been confirmed as an essential element of bidirectional integrin signaling. In recent years, the relationship between Kindlin-2 expression and cancers has been a focus of interest. However, the relationship between Kindlin-2 expression in gastric cancer and tumor invasion, metastasis, and the outcome of patients have not been studied.

METHODS: Kindlin-2 expression at protein and RNA levels were detected by Western blot and real-time polymerase chain reaction in 40 pairs of gastric cancer samples. In addition, the correlations between Kindlin-2 expression and clinicopathologic factors as well as the prognosis of the patients were analyzed. Multivariate Cox regression was used to study the effect of Kindlin-2 expression on overall and progression-free survival.

RESULTS: We found that Kindlin-2 was up-regulated both at RNA (P = .027) and protein levels (P = .014) in gastric cancer tissues. Tumor samples with high Kindlin-2 expression (Kindlin-2/beta-actin:tumor tissue/paraneoplastic tissue, >= 2) was observed in 55% of the patients. Moreover, Kindlin-2 expression had a significant positive correlation with tumor stromal invasion (P = .014), lymph node metastasis (P = .007), and TNM stage (P = .014). Patients with high Kindlin-2 expression had significantly poorer overall survival (P = .012) and progression-free survival (P = .012). High Kindlin-2 expression was an independent risk factor of progression-free survival (hazard ratio, 5.2; 95% confidence interval, 1.1-3.3; P = .032).

CONCLUSIONS: Kindlin-2 may play an important role in the development of gastric cancer and it is a potential factor that could be used to evaluate the outcome of gastric cancer. Kindlin-2 may shed new light on evaluating the prognosis and targeted therapy of gastric cancer. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000300770700017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53190
Appears in Collections:北京大学第二临床医学院_胃肠外科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Surg Gastroenterol, Beijing 100044, Peoples R China
2.Univ Helsinki, Helsinki Univ Cent Hosp, Dept Surg, Helsinki, Finland

Recommended Citation:
Shen, Zhanlong,Ye, Yingjiang,Dong, Lingyi,et al. Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer[J]. AMERICAN JOURNAL OF SURGERY,2012,203(2):222-229.
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