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学科主题: 口腔医学
题名:
The construction of hierarchical structure on Ti substrate with superior osteogenic activity and intrinsic antibacterial capability
作者: Huang, Ying1,2; Zha, Guangyu1; Luo, Qiaojie1; Zhang, Jianxiang3; Zhang, Feng1; Li, Xiaohui3; Zhao, Shifang1; Zhu, Weipu4; Li, Xiaodong1
刊名: SCIENTIFIC REPORTS
发表日期: 2014-08-22
DOI: 10.1038/srep06172
卷: 4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: FUNCTIONALIZED TITANIUM SURFACES ; CONTROLLED CHEMICAL OXIDATION ; BACTERIAL ADHESION ; OSTEOBLAST FUNCTIONS ; CELL RESPONSE ; BONE ; IMPLANTS ; ENERGY ; DIFFERENTIATION ; COATINGS
英文摘要:

The deficient osseointegration and implant-associated infections are pivotal issues for the long-term clinical success of endosteal Ti implants, while development of functional surfaces that can simultaneously overcome these problems remains highly challenging. This study aimed to fabricate sophisticated Ti implant surface with both osteogenic inducing activity and inherent antibacterial ability simply via tailoring surface topographical features. Micro/submciro/nano-scale structure was constructed on Ti by three cumulative subtractive methods, including sequentially conducted sandblasting as well as primary and secondary acid etching treatment. Topographical features of this hierarchical structure can be well tuned by the time of the secondary acid treatment. Ti substrate with mere micro/submicro-scale structure (MS0-Ti) served as a control to examine the influence of hierarchical structures on surface properties and biological activities. Surface analysis indicated that all hierarchically structured surfaces possessed exactly the same surface chemistry as that of MS0-Ti, and all of them showed super-amphiphilicity, high surface free energy, and high protein adsorption capability. Biological evaluations revealed surprisingly antibacterial ability and excellent osteogenic activity for samples with optimized hierarchical structure (MS30-Ti) when compared with MS0-Ti. Consequently, for the first time, a hierarchically structured Ti surface with topography-induced inherent antibacterial capability and excellent osteogenic activity was constructed.

语种: 英语
所属项目编号: 51173163 ; 2012BAI07B01 ; 2012QNA7043
项目资助者: National Natural Science Foundation of China ; National Science-technology Support Plan project of China ; fundamental Research Funds for the Central Universities
WOS记录号: WOS:000340741700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53191
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Zhejiang Univ, Coll Med, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Hangzhou 310006, Zhejiang, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
3.Third Mil Med Univ, Coll Pharm, Dept Pharmaceut, Chongqing 400038, Peoples R China
4.Zhejiang Univ, Dept Polymer Sci & Engn, Hangzhou 310027, Zhejiang, Peoples R China

Recommended Citation:
Huang, Ying,Zha, Guangyu,Luo, Qiaojie,et al. The construction of hierarchical structure on Ti substrate with superior osteogenic activity and intrinsic antibacterial capability[J]. SCIENTIFIC REPORTS,2014,4.
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