IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
The construction of hierarchical structure on Ti substrate with superior osteogenic activity and intrinsic antibacterial capability
Huang, Ying1,2; Zha, Guangyu1; Luo, Qiaojie1; Zhang, Jianxiang3; Zhang, Feng1; Li, Xiaohui3; Zhao, Shifang1; Zhu, Weipu4; Li, Xiaodong1
刊名SCIENTIFIC REPORTS
2014-08-22
DOI10.1038/srep06172
4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]FUNCTIONALIZED TITANIUM SURFACES ; CONTROLLED CHEMICAL OXIDATION ; BACTERIAL ADHESION ; OSTEOBLAST FUNCTIONS ; CELL RESPONSE ; BONE ; IMPLANTS ; ENERGY ; DIFFERENTIATION ; COATINGS
英文摘要

The deficient osseointegration and implant-associated infections are pivotal issues for the long-term clinical success of endosteal Ti implants, while development of functional surfaces that can simultaneously overcome these problems remains highly challenging. This study aimed to fabricate sophisticated Ti implant surface with both osteogenic inducing activity and inherent antibacterial ability simply via tailoring surface topographical features. Micro/submciro/nano-scale structure was constructed on Ti by three cumulative subtractive methods, including sequentially conducted sandblasting as well as primary and secondary acid etching treatment. Topographical features of this hierarchical structure can be well tuned by the time of the secondary acid treatment. Ti substrate with mere micro/submicro-scale structure (MS0-Ti) served as a control to examine the influence of hierarchical structures on surface properties and biological activities. Surface analysis indicated that all hierarchically structured surfaces possessed exactly the same surface chemistry as that of MS0-Ti, and all of them showed super-amphiphilicity, high surface free energy, and high protein adsorption capability. Biological evaluations revealed surprisingly antibacterial ability and excellent osteogenic activity for samples with optimized hierarchical structure (MS30-Ti) when compared with MS0-Ti. Consequently, for the first time, a hierarchically structured Ti surface with topography-induced inherent antibacterial capability and excellent osteogenic activity was constructed.

语种英语
WOS记录号WOS:000340741700004
项目编号51173163 ; 2012BAI07B01 ; 2012QNA7043
资助机构National Natural Science Foundation of China ; National Science-technology Support Plan project of China ; fundamental Research Funds for the Central Universities
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53191
专题北京大学口腔医学院
作者单位1.Zhejiang Univ, Coll Med, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Hangzhou 310006, Zhejiang, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
3.Third Mil Med Univ, Coll Pharm, Dept Pharmaceut, Chongqing 400038, Peoples R China
4.Zhejiang Univ, Dept Polymer Sci & Engn, Hangzhou 310027, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714
Huang, Ying,Zha, Guangyu,Luo, Qiaojie,et al. The construction of hierarchical structure on Ti substrate with superior osteogenic activity and intrinsic antibacterial capability[J]. SCIENTIFIC REPORTS,2014,4.
APA Huang, Ying.,Zha, Guangyu.,Luo, Qiaojie.,Zhang, Jianxiang.,Zhang, Feng.,...&Li, Xiaodong.(2014).The construction of hierarchical structure on Ti substrate with superior osteogenic activity and intrinsic antibacterial capability.SCIENTIFIC REPORTS,4.
MLA Huang, Ying,et al."The construction of hierarchical structure on Ti substrate with superior osteogenic activity and intrinsic antibacterial capability".SCIENTIFIC REPORTS 4(2014).
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