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The role of RND efflux pump and global regulators in tigecycline resistance in clinical Acinetobacter baumannii isolates
Li, Henan; Wang, Xiaojuan; Zhang, Yawei; Zhao, Chunjiang; Chen, Hongbin; Jiang, Sen; Zhang, Feifei; Wang, Hui
关键词Acinetobacter Baumannii Adeb Aders Marr Soxr Tigecycline
刊名FUTURE MICROBIOLOGY
2015
DOI10.2217/FMB.15.7
10期:3页:337-346
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology
研究领域[WOS]Microbiology
关键词[WOS]MULTIPLE-ANTIBIOTIC-RESISTANCE ; IN-VITRO SURVEILLANCE ; ESCHERICHIA-COLI ; DECREASED SUSCEPTIBILITY ; MULTIDRUG-RESISTANCE ; MUTATIONS ; ADEABC ; ADERS ; OVEREXPRESSION ; GENE
英文摘要

Aim: To analyze the expression and regulation of resistance-nodulation-division (RND) efflux systems in clinical tigecycline-nonsusceptible (TNS) Acinetobacter baumannii. Materials & methods: Comparisons of molecular and clinical characteristics were performed between 52 TNS and 53 tigecycline-susceptible isolates. Expression of RND efflux pumps and global regulators were analyzed by real-time RT-PCR. A complementation experiment was performed to evaluate the contribution of the adeRS mutations. Results: Mechanical ventilation and prior use of carbapenems were more common among patients with TNS strains. The relative expression of adeB and adeJ was increased significantly in TNS isolates. Complementarity to the adeR or adeS mutations decreased tigecycline susceptibility by <= 2-fold. Decreased expression of marR and soxR was detected in TNS isolates. Conclusion: A correlation between tigecycline MIC and expression level of adeB and adeJ was identified. The influence of adeRS mutation on adeB expression was limited. Global regulators marR and soxR may be involved in tigecycline resistance.

语种英语
WOS记录号WOS:000351880700009
项目编号31170125 ; 5122041 ; 20110001110043 ; 2012EP001002
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education ; Key Projects in the National Science &amp ; Technology Pillar Program
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53196
专题北京大学第二临床医学院
北京大学第二临床医学院_检验科
作者单位Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China
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GB/T 7714
Li, Henan,Wang, Xiaojuan,Zhang, Yawei,et al. The role of RND efflux pump and global regulators in tigecycline resistance in clinical Acinetobacter baumannii isolates[J]. FUTURE MICROBIOLOGY,2015,10(3):337-346.
APA Li, Henan.,Wang, Xiaojuan.,Zhang, Yawei.,Zhao, Chunjiang.,Chen, Hongbin.,...&Wang, Hui.(2015).The role of RND efflux pump and global regulators in tigecycline resistance in clinical Acinetobacter baumannii isolates.FUTURE MICROBIOLOGY,10(3),337-346.
MLA Li, Henan,et al."The role of RND efflux pump and global regulators in tigecycline resistance in clinical Acinetobacter baumannii isolates".FUTURE MICROBIOLOGY 10.3(2015):337-346.
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