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学科主题: 临床医学
题名:
The role of RND efflux pump and global regulators in tigecycline resistance in clinical Acinetobacter baumannii isolates
作者: Li, Henan; Wang, Xiaojuan; Zhang, Yawei; Zhao, Chunjiang; Chen, Hongbin; Jiang, Sen; Zhang, Feifei; Wang, Hui
关键词: Acinetobacter baumannii ; adeB ; adeRS ; marR ; soxR ; tigecycline
刊名: FUTURE MICROBIOLOGY
发表日期: 2015
DOI: 10.2217/FMB.15.7
卷: 10, 期:3, 页:337-346
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: MULTIPLE-ANTIBIOTIC-RESISTANCE ; IN-VITRO SURVEILLANCE ; ESCHERICHIA-COLI ; DECREASED SUSCEPTIBILITY ; MULTIDRUG-RESISTANCE ; MUTATIONS ; ADEABC ; ADERS ; OVEREXPRESSION ; GENE
英文摘要:

Aim: To analyze the expression and regulation of resistance-nodulation-division (RND) efflux systems in clinical tigecycline-nonsusceptible (TNS) Acinetobacter baumannii. Materials & methods: Comparisons of molecular and clinical characteristics were performed between 52 TNS and 53 tigecycline-susceptible isolates. Expression of RND efflux pumps and global regulators were analyzed by real-time RT-PCR. A complementation experiment was performed to evaluate the contribution of the adeRS mutations. Results: Mechanical ventilation and prior use of carbapenems were more common among patients with TNS strains. The relative expression of adeB and adeJ was increased significantly in TNS isolates. Complementarity to the adeR or adeS mutations decreased tigecycline susceptibility by <= 2-fold. Decreased expression of marR and soxR was detected in TNS isolates. Conclusion: A correlation between tigecycline MIC and expression level of adeB and adeJ was identified. The influence of adeRS mutation on adeB expression was limited. Global regulators marR and soxR may be involved in tigecycline resistance.

语种: 英语
所属项目编号: 31170125 ; 5122041 ; 20110001110043 ; 2012EP001002
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education ; Key Projects in the National Science &amp ; Technology Pillar Program
WOS记录号: WOS:000351880700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53196
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China

Recommended Citation:
Li, Henan,Wang, Xiaojuan,Zhang, Yawei,et al. The role of RND efflux pump and global regulators in tigecycline resistance in clinical Acinetobacter baumannii isolates[J]. FUTURE MICROBIOLOGY,2015,10(3):337-346.
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