北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Tumor suppressor cylindromatosis: expressed in IgA nephropathy and negatively associated with renal tubulo-interstitial lesion
作者: Sun Fang1; Zheng Xin2,3; E Jie2,3; Liu Gang2,3; Wang Zhi-gang4; Cui Tai-gen1
关键词: cylindromatosis ; IgA nephropathy ; tubular epithelial cells ; proteinuria ; glomerular filtration rate
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2009-11-05
DOI: 10.3760/cma.j.issn.0366-6999.2009.21.014
卷: 122, 期:21, 页:2603-2607
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: NF-KAPPA-B ; DEUBIQUITINATING ENZYME ; CYLD ; PROTEINURIA ; ACTIVATION ; APOPTOSIS ; DISEASES ; CELLS
英文摘要:

Background IgA nephropathy is the major cause of end-stage renal failure in patients with primary glomerular diseases. Tumor suppressor cylindromatosis (CYLD), the recently identified member of the deubiquitinating enzymes, has been actively involved in regulation of inflammation. This study was undertaken to investigate the CYLD expression profile in IgA nephropathy and identify factors associated with CYLD expression.

Methods Forty-one cases of IgA nephropathy were selected. CYLD expression in the kidney biopsy tissue was measured by immunohistochemical staining. Relevant clinical and pathological data were analyzed, and Logistic regression analysis was carried out to identify factors associated with CYLD expression.

Results CYLD was specifically expressed in renal tubular epithelial cells in 70% of the studied patients with IgA nephropathy. All patients with positive CYLD staining had proteinuria, while only 72.7% of patients with negative CYLD had proteinuria (P=0.003). Among studied proteinuric patients, those with positive CYLD had significantly less tubulo-interstitial lesions and higher estimated glomerular filtration rate (eGFR) levels when compared with those patients showed negative CYLD results. Logistic regression analysis indicated that the urinary protein excretion and eGFR were identified as predictors for the CYLD expression.

Conclusion CYLD is expressed in renal tubular epithelial cells and appears to be associated negatively with tubulointerstitial lesions, however, its exact functional role remains to be clarified in further experiments. Chin Med J 2009;122(21):2603-2607

语种: 英语
WOS记录号: WOS:000271893200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53200
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Capital Med Univ, Beijing Chaoyang Hosp, Dept Nephrol, Beijing 100025, Peoples R China
3.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
4.Capital Med Univ, Beijing Friendship Hosp, Dept Nephrol, Beijing 100050, Peoples R China

Recommended Citation:
Sun Fang,Zheng Xin,E Jie,et al. Tumor suppressor cylindromatosis: expressed in IgA nephropathy and negatively associated with renal tubulo-interstitial lesion[J]. CHINESE MEDICAL JOURNAL,2009,122(21):2603-2607.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun Fang]'s Articles
[Zheng Xin]'s Articles
[E Jie]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun Fang]‘s Articles
[Zheng Xin]‘s Articles
[E Jie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace