IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Tumor suppressor cylindromatosis: expressed in IgA nephropathy and negatively associated with renal tubulo-interstitial lesion
Sun Fang1; Zheng Xin2,3; E Jie2,3; Liu Gang2,3; Wang Zhi-gang4; Cui Tai-gen1
关键词Cylindromatosis Iga Nephropathy Tubular Epithelial Cells Proteinuria Glomerular Filtration Rate
刊名CHINESE MEDICAL JOURNAL
2009-11-05
DOI10.3760/cma.j.issn.0366-6999.2009.21.014
122期:21页:2603-2607
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]NF-KAPPA-B ; DEUBIQUITINATING ENZYME ; CYLD ; PROTEINURIA ; ACTIVATION ; APOPTOSIS ; DISEASES ; CELLS
英文摘要

Background IgA nephropathy is the major cause of end-stage renal failure in patients with primary glomerular diseases. Tumor suppressor cylindromatosis (CYLD), the recently identified member of the deubiquitinating enzymes, has been actively involved in regulation of inflammation. This study was undertaken to investigate the CYLD expression profile in IgA nephropathy and identify factors associated with CYLD expression.

Methods Forty-one cases of IgA nephropathy were selected. CYLD expression in the kidney biopsy tissue was measured by immunohistochemical staining. Relevant clinical and pathological data were analyzed, and Logistic regression analysis was carried out to identify factors associated with CYLD expression.

Results CYLD was specifically expressed in renal tubular epithelial cells in 70% of the studied patients with IgA nephropathy. All patients with positive CYLD staining had proteinuria, while only 72.7% of patients with negative CYLD had proteinuria (P=0.003). Among studied proteinuric patients, those with positive CYLD had significantly less tubulo-interstitial lesions and higher estimated glomerular filtration rate (eGFR) levels when compared with those patients showed negative CYLD results. Logistic regression analysis indicated that the urinary protein excretion and eGFR were identified as predictors for the CYLD expression.

Conclusion CYLD is expressed in renal tubular epithelial cells and appears to be associated negatively with tubulointerstitial lesions, however, its exact functional role remains to be clarified in further experiments. Chin Med J 2009;122(21):2603-2607

语种英语
WOS记录号WOS:000271893200014
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53200
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Div Renal, Beijing 100034, Peoples R China
2.Capital Med Univ, Beijing Chaoyang Hosp, Dept Nephrol, Beijing 100025, Peoples R China
3.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
4.Capital Med Univ, Beijing Friendship Hosp, Dept Nephrol, Beijing 100050, Peoples R China
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GB/T 7714
Sun Fang,Zheng Xin,E Jie,et al. Tumor suppressor cylindromatosis: expressed in IgA nephropathy and negatively associated with renal tubulo-interstitial lesion[J]. CHINESE MEDICAL JOURNAL,2009,122(21):2603-2607.
APA Sun Fang,Zheng Xin,E Jie,Liu Gang,Wang Zhi-gang,&Cui Tai-gen.(2009).Tumor suppressor cylindromatosis: expressed in IgA nephropathy and negatively associated with renal tubulo-interstitial lesion.CHINESE MEDICAL JOURNAL,122(21),2603-2607.
MLA Sun Fang,et al."Tumor suppressor cylindromatosis: expressed in IgA nephropathy and negatively associated with renal tubulo-interstitial lesion".CHINESE MEDICAL JOURNAL 122.21(2009):2603-2607.
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