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学科主题基础医学
Angiotensin-(1-7) inhibits vascular calcification in rats
Sui, Yu-Bin1; Chang, Jin-Rui2; Chen, Wen-Jia1; Zhao, Lei2; Zhang, Bao-Hong4; Yu, Yan-Rong2,3; Tang, Chao-Shu2,3; Yin, Xin-Hua1; Qi, Yong-Fen2,3
关键词Angiotensin-(1-7) Vascular Calcification Angiotensin Converting Enzyme 2 (Ace2) Mas Receptor
刊名PEPTIDES
2013-04-01
DOI10.1016/j.peptides.2012.12.023
42页:25-34
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]CHRONIC KIDNEY-DISEASE ; SMOOTH-MUSCLE-CELLS ; VITAMIN-D-3 PLUS NICOTINE ; CONVERTING ENZYME ; ATHEROSCLEROTIC LESIONS ; ARTERIAL CALCIFICATION ; MYOCARDIAL-INFARCTION ; CLINICAL-IMPLICATIONS ; ACE2 EXPRESSION ; RECEPTOR
英文摘要

Angiotensin-(1-7) [Ang-(1-7)] is a new bioactive heptapeptide in the renin-angiotensin-aldosterone system (RAAS) with potent protective effects in cardiovascular diseases, opposing many actions of angiotensin II (Ang II) mediated by Ang II type 1 (AT1) receptor. It is produced mainly by the activity of angiotensin-converting enzyme 2 (ACE2) and acts through the Mas receptor. However, the role of Ang-(1-7) in vascular calcification (VC) is still unclear. In this study, we investigated the protective effects of Ang-(1-7) on VC in an in vivo rat VC model induced by vitamin D-3 plus nicotine. The levels of ACE2 and the Mas receptor, as well as ACE, AT1 receptor, Ang II type 2 receptor and angiotensinogen, were significantly increased in calcified aortas, and Ang-(1-7) reversed the increased levels. Ang-(1-7) restored the reduced expression of lineage markers, including smooth muscle (SM) alpha-actin, SM22 alpha, calponin and smoothelin, in vascular smooth muscle cells (VSMCs) and retarded the osteogenic transition of VSMCs by decreasing the expression of bone-associated proteins. It reduced alkaline phosphatase activity and calcium deposition in VC and alleviated the hemodynamic disorders of rats with VC. We provide the first in vivo evidence that Ang-(1-7) can inhibit the development of VC by inhibiting the osteogenic transition of VSMCs, at least in part by decreasing levels of the ACE/Ang II/AT1 axis. The increased expression of ACE2 and the Mas receptor in calcified aortas suggests the involvement of the ACE2/Ang-(1-7)/Mas axis during VC. Ang-(1-7) might be an efficient endogenous vasoprotective factor for VC. (c) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000320492800004
项目编号JC201001 ; 81270407
资助机构Heilongjiang Outstanding Youth Science Fund ; National Nature Science Foundation of China ; Leading Academic Discipline Project of Beijing Education Bureau
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53203
专题北京大学基础医学院
北京大学第二临床医学院_血液科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Capital Inst Pediat, Beijing 100020, Peoples R China
3.Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Heilongjiang, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Lab Cardiovasc Bioact Mol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Sui, Yu-Bin,Chang, Jin-Rui,Chen, Wen-Jia,et al. Angiotensin-(1-7) inhibits vascular calcification in rats[J]. PEPTIDES,2013,42:25-34.
APA Sui, Yu-Bin.,Chang, Jin-Rui.,Chen, Wen-Jia.,Zhao, Lei.,Zhang, Bao-Hong.,...&Qi, Yong-Fen.(2013).Angiotensin-(1-7) inhibits vascular calcification in rats.PEPTIDES,42,25-34.
MLA Sui, Yu-Bin,et al."Angiotensin-(1-7) inhibits vascular calcification in rats".PEPTIDES 42(2013):25-34.
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