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学科主题: 临床医学
题名:
Wilms′ tumor gene 1 expression: an independent acute leukemia prognostic indicator following allogeneic hematopoietic SCT
作者: Zhao, X-S; Jin, S.; Zhu, H-H; Xu, L-P; Liu, D-H; Chen, H.; Liu, K-Y; Huang, X-J
关键词: allogeneic hematopoietic SCT ; Wilms&prime ; tumor gene 1 ; relapse ; minimal residual diseases ; acute leukemia
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2012-04-01
DOI: 10.1038/bmt.2011.121
卷: 47, 期:4, 页:499-507
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: ACUTE MYELOID-LEUKEMIA ; MINIMAL RESIDUAL DISEASE ; STEM-CELL TRANSPLANTATION ; POLYMERASE-CHAIN-REACTION ; BCR-ABL ; TRANSCRIPT LEVELS ; CANCER PROGRAM ; BONE-MARROW ; WT1 ; RELAPSE
英文摘要:

To evaluate the prognostic significance of Wilms′ tumor gene 1 (WT1) expression for monitoring minimal residual disease and predicting relapse in patients with acute leukemia (AL) following allogeneic hematopoietic SCT (allo-HSCT), the WT1 expression levels of 138 AL patients were measured using real-time quantitative reverse transcription PCR at designed time points after allo-HSCT. All patients were divided into four groups based on the HSCT outcomes and intervention application. A low level of WT1 expression following HSCT indicated a low risk of relapse, whereas WT1 expression >1.05% was indicative of a higher probability of relapse. Only the advanced stage of disease (hazard ratio (HR) = 2.73; 95% confidence interval (CI) = 1.337-5.573, P = 0.006) and a WT1 expression >= 0.60% (HR = 4.774; 95% CI = 2.410-9.459, P = 0.000) were associated with lower disease-free survival. Relapse (HR = 0.119; 95% CI = 0.056-0.250, P = 0.000) and a WT1 expression >= 0.60% (HR = 2.771; 95% CI = 1.316-5.834, P = 0.007) were associated with lower OS. In conclusion, the WT1 expression level is an independent prognostic factor that can predict clinical outcomes for AL patients after HSCT and provide a guide for suitable interventions. Bone Marrow Transplantation (2012) 47, 499-507; doi:10.1038/bmt.2011.121; published online 6 June 2011

语种: 英语
所属项目编号: 30725038 ; IRT 0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Program for Innovative Research Team in University ; Ministry of Health of China
WOS记录号: WOS:000302576700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53206
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Dept Bone Marrow Transplantat, Beijing 100044, Peoples R China

Recommended Citation:
Zhao, X-S,Jin, S.,Zhu, H-H,et al. Wilms′ tumor gene 1 expression: an independent acute leukemia prognostic indicator following allogeneic hematopoietic SCT[J]. BONE MARROW TRANSPLANTATION,2012,47(4):499-507.
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