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Wilms′ tumor gene 1 expression: an independent acute leukemia prognostic indicator following allogeneic hematopoietic SCT
Zhao, X-S; Jin, S.; Zhu, H-H; Xu, L-P; Liu, D-H; Chen, H.; Liu, K-Y; Huang, X-J
关键词Allogeneic Hematopoietic Sct Wilms&Prime Tumor Gene 1 Relapse Minimal Residual Diseases Acute Leukemia
刊名BONE MARROW TRANSPLANTATION
2012-04-01
DOI10.1038/bmt.2011.121
47期:4页:499-507
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]ACUTE MYELOID-LEUKEMIA ; MINIMAL RESIDUAL DISEASE ; STEM-CELL TRANSPLANTATION ; POLYMERASE-CHAIN-REACTION ; BCR-ABL ; TRANSCRIPT LEVELS ; CANCER PROGRAM ; BONE-MARROW ; WT1 ; RELAPSE
英文摘要

To evaluate the prognostic significance of Wilms′ tumor gene 1 (WT1) expression for monitoring minimal residual disease and predicting relapse in patients with acute leukemia (AL) following allogeneic hematopoietic SCT (allo-HSCT), the WT1 expression levels of 138 AL patients were measured using real-time quantitative reverse transcription PCR at designed time points after allo-HSCT. All patients were divided into four groups based on the HSCT outcomes and intervention application. A low level of WT1 expression following HSCT indicated a low risk of relapse, whereas WT1 expression >1.05% was indicative of a higher probability of relapse. Only the advanced stage of disease (hazard ratio (HR) = 2.73; 95% confidence interval (CI) = 1.337-5.573, P = 0.006) and a WT1 expression >= 0.60% (HR = 4.774; 95% CI = 2.410-9.459, P = 0.000) were associated with lower disease-free survival. Relapse (HR = 0.119; 95% CI = 0.056-0.250, P = 0.000) and a WT1 expression >= 0.60% (HR = 2.771; 95% CI = 1.316-5.834, P = 0.007) were associated with lower OS. In conclusion, the WT1 expression level is an independent prognostic factor that can predict clinical outcomes for AL patients after HSCT and provide a guide for suitable interventions. Bone Marrow Transplantation (2012) 47, 499-507; doi:10.1038/bmt.2011.121; published online 6 June 2011

语种英语
WOS记录号WOS:000302576700006
项目编号30725038 ; IRT 0702
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; Program for Innovative Research Team in University ; Ministry of Health of China
引用统计
被引频次:47[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53206
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Dept Bone Marrow Transplantat, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhao, X-S,Jin, S.,Zhu, H-H,et al. Wilms′ tumor gene 1 expression: an independent acute leukemia prognostic indicator following allogeneic hematopoietic SCT[J]. BONE MARROW TRANSPLANTATION,2012,47(4):499-507.
APA Zhao, X-S.,Jin, S..,Zhu, H-H.,Xu, L-P.,Liu, D-H.,...&Huang, X-J.(2012).Wilms′ tumor gene 1 expression: an independent acute leukemia prognostic indicator following allogeneic hematopoietic SCT.BONE MARROW TRANSPLANTATION,47(4),499-507.
MLA Zhao, X-S,et al."Wilms′ tumor gene 1 expression: an independent acute leukemia prognostic indicator following allogeneic hematopoietic SCT".BONE MARROW TRANSPLANTATION 47.4(2012):499-507.
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