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学科主题: 基础医学
题名:
Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis
作者: Li, N.; Zhao, G.; Chen, T.; Xue, L.; Ma, L.; Niu, J.; Tong, T.
关键词: apoptosis ; CSIG ; p33ING1 ; Bax ; nucleolar protein ; UV irradiation
刊名: CELL DEATH & DISEASE
发表日期: 2012-03-01
DOI: 10.1038/cddis.2012.22
卷: 3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: CANDIDATE TUMOR-SUPPRESSOR ; CELL-PROLIFERATION ; DNA-DAMAGE ; HUMAN FIBROBLASTS ; MELANOMA-CELLS ; P53 ; P33(ING1) ; ING1 ; DEATH ; PHOSPHORYLATION
英文摘要:

Cellular senescence-inhibited gene (CSIG) protein, a nucleolar protein with a ribosomal L1 domain in its N-terminus, can exert non-ribosomal functions to regulate biological processes, such as cellular senescence. Here, we describe a previously unknown function for CSIG: promotion of apoptosis in response to ultraviolet (UV) irradiation-induced CSIG upregulation. We identified p33ING1 as a binding partner that interacts with CSIG. After UV irradiation, p33ING1 increases its protein expression, translocates into the nucleolus and binds CSIG. p33ING1 requires its nucleolar targeting sequence region to interact with CSIG and enhance CSIG protein stability, which is essential for activation of downstream effectors, Bcl-2-associated X protein, to promote apoptosis. Thus, our data imply that p33ING1-CSIG axis functions as a novel pro-apoptotic regulator in response to DNA damage. Cell Death and Disease (2012) 3, e283; doi:10.1038/cddis.2012.22; published online 15 March 2012

语种: 英语
所属项目编号: 2012CB911200 ; 81170319 ; 31071206
项目资助者: National Basic Research Programs of China ; National Natural Science Foundation of China
WOS记录号: WOS:000302143800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53207
Appears in Collections:基础医学院_北京大学衰老研究中心_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Res Ctr Aging, Beijing 100191, Peoples R China

Recommended Citation:
Li, N.,Zhao, G.,Chen, T.,et al. Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis[J]. CELL DEATH & DISEASE,2012,3.
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