学科主题基础医学
Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis
Li, N.; Zhao, G.; Chen, T.; Xue, L.; Ma, L.; Niu, J.; Tong, T.
关键词Apoptosis Csig P33ing1 Bax Nucleolar Protein Uv Irradiation
刊名CELL DEATH & DISEASE
2012-03-01
DOI10.1038/cddis.2012.22
3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]CANDIDATE TUMOR-SUPPRESSOR ; CELL-PROLIFERATION ; DNA-DAMAGE ; HUMAN FIBROBLASTS ; MELANOMA-CELLS ; P53 ; P33(ING1) ; ING1 ; DEATH ; PHOSPHORYLATION
英文摘要

Cellular senescence-inhibited gene (CSIG) protein, a nucleolar protein with a ribosomal L1 domain in its N-terminus, can exert non-ribosomal functions to regulate biological processes, such as cellular senescence. Here, we describe a previously unknown function for CSIG: promotion of apoptosis in response to ultraviolet (UV) irradiation-induced CSIG upregulation. We identified p33ING1 as a binding partner that interacts with CSIG. After UV irradiation, p33ING1 increases its protein expression, translocates into the nucleolus and binds CSIG. p33ING1 requires its nucleolar targeting sequence region to interact with CSIG and enhance CSIG protein stability, which is essential for activation of downstream effectors, Bcl-2-associated X protein, to promote apoptosis. Thus, our data imply that p33ING1-CSIG axis functions as a novel pro-apoptotic regulator in response to DNA damage. Cell Death and Disease (2012) 3, e283; doi:10.1038/cddis.2012.22; published online 15 March 2012

语种英语
WOS记录号WOS:000302143800010
项目编号2012CB911200 ; 81170319 ; 31071206
资助机构National Basic Research Programs of China ; National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53207
专题北京大学基础医学院_北京大学衰老研究中心
北京大学第三临床医学院_心血管内科
北京大学口腔医学院_第二门诊部
作者单位Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Res Ctr Aging, Beijing 100191, Peoples R China
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GB/T 7714
Li, N.,Zhao, G.,Chen, T.,et al. Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis[J]. CELL DEATH & DISEASE,2012,3.
APA Li, N..,Zhao, G..,Chen, T..,Xue, L..,Ma, L..,...&Tong, T..(2012).Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis.CELL DEATH & DISEASE,3.
MLA Li, N.,et al."Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis".CELL DEATH & DISEASE 3(2012).
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