北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
The effect of 7-nitroindazole on the acquisition and expression of D-methamphetamine-induced place preference in rats
作者: Li, SM1; Yin, LL1; Shi, J1; Lin, ZB1; Zheng, JW1
关键词: D-methamphetamine ; conditioned place preference ; nitric oxide (NO) ; 7-nitroindazole ; reward
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2002-01-25
卷: 435, 期:2-3, 页:217-223
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; INDUCED LOCOMOTOR SENSITIZATION ; LONG-TERM POTENTIATION ; BEHAVIORAL SENSITIZATION ; 7-NITRO INDAZOLE ; INDUCED NEUROTOXICITY ; STIMULUS PROPERTIES ; GLUTAMATE RELEASE ; DOPAMINE EFFLUX ; DEFICIENT MICE
英文摘要:

The present study investigated the role of nitric oxide (NO) in the rewarding effects Of D-Methamphetamine using 7-nitroindazole, a potent inhibitor of neuronal nitric oxide synthase (nNOS), as determined by the conditioned place preference paradigm. Male Sprague-Dawley rats treated with D-methamphetamine (I mg/kg) or saline every other day for 8 days (four drug and four saline sessions) developed marked place preference for the drug-paired side. The administration of 7-nitroindazole (12.5-50 mg/kg) 30 min prior to the exposure to D-methamphetamine dose-dependently attenuated the acquisition Of D-methamphetamine-induced conditioned place preference. In addition, when it was acutely administered 30 min prior to the testing session of an already established D-methamphetamine-induced conditioned place preference, 7-nitroindazole (12.5-50 mg/kg) attenuated the expression of this conditioned response in a dose-dependent manner, while 7-nitroindazole (25 and 50 mg/kg) alone showed no place preference effects. These findings indicate that nitric oxide (NO) is involved in the rewarding properties of methamphetamine and suggest that selective nNOS inhibitors maybe useful in the management of methamphetamine abuse. (C) 2002 Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000173793200013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53210
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Li, SM,Yin, LL,Shi, J,et al. The effect of 7-nitroindazole on the acquisition and expression of D-methamphetamine-induced place preference in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2002,435(2-3):217-223.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, SM]'s Articles
[Yin, LL]'s Articles
[Shi, J]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, SM]‘s Articles
[Yin, LL]‘s Articles
[Shi, J]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace