IR@PKUHSC  > 中国药物依赖性研究所
学科主题药物依赖
The effect of 7-nitroindazole on the acquisition and expression of D-methamphetamine-induced place preference in rats
Li, SM1; Yin, LL1; Shi, J1; Lin, ZB1; Zheng, JW1
关键词D-methamphetamine Conditioned Place Preference Nitric Oxide (No) 7-nitroindazole Reward
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2002-01-25
435期:2-3页:217-223
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]NITRIC-OXIDE SYNTHASE ; INDUCED LOCOMOTOR SENSITIZATION ; LONG-TERM POTENTIATION ; BEHAVIORAL SENSITIZATION ; 7-NITRO INDAZOLE ; INDUCED NEUROTOXICITY ; STIMULUS PROPERTIES ; GLUTAMATE RELEASE ; DOPAMINE EFFLUX ; DEFICIENT MICE
英文摘要

The present study investigated the role of nitric oxide (NO) in the rewarding effects Of D-Methamphetamine using 7-nitroindazole, a potent inhibitor of neuronal nitric oxide synthase (nNOS), as determined by the conditioned place preference paradigm. Male Sprague-Dawley rats treated with D-methamphetamine (I mg/kg) or saline every other day for 8 days (four drug and four saline sessions) developed marked place preference for the drug-paired side. The administration of 7-nitroindazole (12.5-50 mg/kg) 30 min prior to the exposure to D-methamphetamine dose-dependently attenuated the acquisition Of D-methamphetamine-induced conditioned place preference. In addition, when it was acutely administered 30 min prior to the testing session of an already established D-methamphetamine-induced conditioned place preference, 7-nitroindazole (12.5-50 mg/kg) attenuated the expression of this conditioned response in a dose-dependent manner, while 7-nitroindazole (25 and 50 mg/kg) alone showed no place preference effects. These findings indicate that nitric oxide (NO) is involved in the rewarding properties of methamphetamine and suggest that selective nNOS inhibitors maybe useful in the management of methamphetamine abuse. (C) 2002 Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000173793200013
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53210
专题中国药物依赖性研究所
北京大学基础医学院
北京大学第三临床医学院_动物实验中心
北京大学临床肿瘤学院_肝胆胰外一科
作者单位1.Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, SM,Yin, LL,Shi, J,et al. The effect of 7-nitroindazole on the acquisition and expression of D-methamphetamine-induced place preference in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2002,435(2-3):217-223.
APA Li, SM,Yin, LL,Shi, J,Lin, ZB,&Zheng, JW.(2002).The effect of 7-nitroindazole on the acquisition and expression of D-methamphetamine-induced place preference in rats.EUROPEAN JOURNAL OF PHARMACOLOGY,435(2-3),217-223.
MLA Li, SM,et al."The effect of 7-nitroindazole on the acquisition and expression of D-methamphetamine-induced place preference in rats".EUROPEAN JOURNAL OF PHARMACOLOGY 435.2-3(2002):217-223.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
The effect of 7-nitr(219KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, SM]的文章
[Yin, LL]的文章
[Shi, J]的文章
百度学术
百度学术中相似的文章
[Li, SM]的文章
[Yin, LL]的文章
[Shi, J]的文章
必应学术
必应学术中相似的文章
[Li, SM]的文章
[Yin, LL]的文章
[Shi, J]的文章
相关权益政策
暂无数据
收藏/分享
文件名: The effect of 7-nitroindazole on the acquisition and expression of D-methamphetamine-induced place preference in rats.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。