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学科主题临床医学
Prediction of the prognosis in patients with acute-on-chronic hepatitis using the MELD scoring system
Yu, Jian-Wu1; Wang, Gui-Qiang1; Li, Shu-Chen1
关键词Acute-on-chronic Hepatitis Model For End-stage Liver Disease Mortality Prognosis Receiver-operating Characteristic Curve
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2006-10-01
DOI10.1111/j.1440-1746.2006.04510.x
21期:10页:1519-1524
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]ACUTE LIVER-FAILURE ; CIRRHOSIS ; FULMINANT ; SURVIVAL ; ASCITES ; TRANSPLANTATION ; ALLOCATION ; DISEASE ; CHILD ; MODEL
英文摘要

To predict prognosis in patients with acute-on-chronic hepatitis (AOCH) using the model for end-stage liver disease (MELD) scoring system and to study the effects of age, sex, etiology, low serum sodium, and persistent ascites on MELD.

The MELD scores of 300 patients with AOCH were calculated according to the original formula. The 3-month mortality in patients was measured, and the validity of the models was determined by means of the concordance (c) statistic. The influential factors on MELD were also assessed.

The 3-month mortality of AOCH patients with a MELD score of 20-29 was 56.0%, with a score of 30-39 it was 76.5%, and with a score over 40 it was 98.2%. The concordance (c) statistic of 3-month mortality was 0.782. Univariate analysis showed that mortality was significantly related to age (P = 0.047), etiology (P = 0.039), serum sodium (P = 0.029) and ascites (P = 0.031) for patients with MELD scores 20-29. In multivariate analysis, in patients with MELD scores 20-29, age (P = 0.012), etiology (P = 0.024), serum sodium (P = 0.005) and ascites (P = 0.017) were independent predictors of mortality; for MELD scores above 30, only MELD score (P = 0.015) was independently predictive.

The MELD scoring system is a reliable method for predicting mortality in patients with AOCH. In the group with MELD score 20-29, factors including age, etiology, presence of low serum sodium and persistent ascites may influence the MELD scoring system. The MELD score is the decisive predictor of the prognosis of patients with AOCH when the MELD score is over 30.

语种英语
WOS记录号WOS:000239863300003
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53217
专题北京大学第一临床医学院_感染疾病科
作者单位1.Harbon Med Univ, Affiliated Hosp 2, Dept Infect Dis, Harbin 150086, Peoples R China
2.Peking Univ, Hosp 1, Dept Infect Dis, Beijing, Peoples R China
推荐引用方式
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Yu, Jian-Wu,Wang, Gui-Qiang,Li, Shu-Chen. Prediction of the prognosis in patients with acute-on-chronic hepatitis using the MELD scoring system[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2006,21(10):1519-1524.
APA Yu, Jian-Wu,Wang, Gui-Qiang,&Li, Shu-Chen.(2006).Prediction of the prognosis in patients with acute-on-chronic hepatitis using the MELD scoring system.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,21(10),1519-1524.
MLA Yu, Jian-Wu,et al."Prediction of the prognosis in patients with acute-on-chronic hepatitis using the MELD scoring system".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21.10(2006):1519-1524.
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