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FTIR spectroscopic explorations of freshly resected thyroid malignant tissues
Zeng Xiang-tai1,3; Xu Yi-zhuang2; Zhang Yiao-qing1; Xu Zhi1; Zhang Yuan-fu2; Wu Jin-guang2; Zhou Xiao-si1; Ling Xiao-feng1
关键词Ftir Thyroid Cancer Fresh Resected Tissue
刊名SPECTROSCOPY AND SPECTRAL ANALYSIS
2007-12-01
27期:12页:2422-2426
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Spectroscopy
研究领域[WOS]Spectroscopy
关键词[WOS]TRANSFORM INFRARED-SPECTROSCOPY ; CANCER ; DIAGNOSIS ; NODULES
英文摘要

In the present paper, 17 cases of freshly resected malignant thyroid tissue samples and 23 cases of benign thyroid tissue samples were characterized using FTIR spectroscopy with an ATR probe. Statistic analysis indicated that the FTIR spectra of cancerous tissue were significantly different from those of benign tissue. In comparison with normal tissues, the FTIR spectra of malignant thyroid tissues possess the following features: (1) Variation of bands related to protein: Amide I band shifted to lower wave number significantly. (P<0.01), while amide II band shifted to higher wave number(P<0.05), and the ratios of I-1640/I-1460 and I-1640/I-1550 were raised(P<0.01). The authors can conclude that the amounts and the secondary structure of protein in malignant tissue changed. (2)The peaks at 2 955, 2 920, 2 870, 2 850 and 1740 cm(-1) appeared less frequently suggesting that the relative quantity of lipid in malignant tissue decreased significantly; (3) Variation of bands related to nucleic acid: The band of 1241 cm(-1) shifted to (1 238.29 +/- 2.87)cm(-1), and the ratios of I-1080/I-1460 were raised significantly(P<0.05). The most possible reason for the changes was that the mutation of DNA and the amounts of nucleic acid had increased in malignant neoplasms. Experimental results show that the malignant thyroid tissues can be distinguished from the benign tissues by their infrared spectra. This approach proves that FTIR spectroscopy is a reliable and practicable method for thyroid cancer diagnosis in operations. The authors have expanded their research on detecting the thyroid cancer FTIR spectra via percutaneous and in vivo, and have achieved a positive result which is going to be reported in another paper.

语种中文
WOS记录号WOS:000253064500011
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53219
专题北京大学第三临床医学院_普通外科
作者单位1.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100083, Peoples R China
2.Peking Univ, Coll Chem Mol Engn, Beijing 100871, Peoples R China
3.First Affiliated Hosp, Gan Nan Med Coll, Dept Gen Surg 2, Ganzhou 341000, Peoples R China
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GB/T 7714
Zeng Xiang-tai,Xu Yi-zhuang,Zhang Yiao-qing,et al. FTIR spectroscopic explorations of freshly resected thyroid malignant tissues[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2007,27(12):2422-2426.
APA Zeng Xiang-tai.,Xu Yi-zhuang.,Zhang Yiao-qing.,Xu Zhi.,Zhang Yuan-fu.,...&Ling Xiao-feng.(2007).FTIR spectroscopic explorations of freshly resected thyroid malignant tissues.SPECTROSCOPY AND SPECTRAL ANALYSIS,27(12),2422-2426.
MLA Zeng Xiang-tai,et al."FTIR spectroscopic explorations of freshly resected thyroid malignant tissues".SPECTROSCOPY AND SPECTRAL ANALYSIS 27.12(2007):2422-2426.
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